Log In Sign up
The largest database of trusted experimental protocols

8 hydroxy 2 dipropylaminotetralin hydrobromide 8 oh dpat

Manufactured by Bio-Techne
Visit Supplier
Sourced in United Kingdom, Spain

8-hydroxy-2-dipropylaminotetralin hydrobromide (8-OH-DPAT) is a chemical compound that acts as a selective agonist for the 5-HT1A receptor. It is often used as a research tool in various scientific studies.

Automatically generated - may contain errors

Lab products found in correlation

Ketanserin, by Bio-Techne (1 mentions) Ondansetron hydrochloride, by Merck Group (1 mentions) Nan 190, by Bio-Techne (1 mentions) Fluoxetine hydrochloride, by Bio-Techne (1 mentions) Atenolol, by Merck Group (1 mentions)

Close spelling variants of this product

8-OH-DPAT (11 citations) 8-hydroxy-2-dipropylaminotetralin hydrobromide (2 citations)

3 protocols using 8 hydroxy 2 dipropylaminotetralin hydrobromide 8 oh dpat

1

Pharmacological Modulation of Synaptic Transmission

Check if the same lab product or an alternative is used in the 5 most similar protocols
Drugs including 5-Hydroxytryptamine (5-HT), DNQX, 8-hydroxy-2-dipropylaminotetralin hydrobromide (8-OH-DPAT), N-(piperidin-1-yl)-5-(4-iodophenyl)-1-(2,4-dichlorophenyl)-4-methyl-1H-pyrazole-3-carboxamide (AM251), D-AP5, 1-(m-chlorophenyl) biguanide hydrochloride (mCPBG), NAN-190, ketanserin, and 1,2-bis(2-aminophenoxy)ethane-N,N,N',N'-tetraacetic acid (BAPTA) were purchased from Tocris Bioscience (Bristol, UK). ondansetron hydrochloride, α-methyl-5-hydroxytryptamine (α-me-5-HT), CCh, and atropine were purchased from Sigma-Aldrich (St Louis, MO, USA). BAPTA was included in the pipette solution. NAN-190 and AM251 were dissolved in dimethyl sulfoxide (DMSO, 0.1%).
Shin D., Cho K.H., Joo K, & Rhie D.J. (2020). Layer-specific serotonergic induction of long-term depression in the prefrontal cortex of rats. The Korean Journal of Physiology & Pharmacology : Official Journal of the Korean Physiological Society and the Korean Society of Pharmacology, 24(6), 517-527.
+ Open protocol
+ Expand
2

Radioactive Ligand Binding Assay

Check if the same lab product or an alternative is used in the 5 most similar protocols
[35S]-2′-deoxyadenosine-5′-(α-thio)triphosphate
(dATP) and [35S]-guanosine-5′-(γ-thio)triphosphate
(GTPγS) were used at a specific activity of 1250 Ci/mmol (PerkinElmer).
Fluoxetine hydrochloride and (±)-8-hydroxy-2-dipropylaminotetralin
hydrobromide (8-OH-DPAT) were purchased from Tocris Bioscience, and
corticosterone hemisuccinate (4-pregnen-11b-DIOL-3 20-DIONE 21-hemisuccinate)
was from Steraloids. All other chemicals used were of analytical grade.
Amigo J., Garro-Martinez E., Vidal Casado R., Compan V., Pilar-Cuéllar F., Pazos A., Díaz A, & Castro E. (2021). 5-HT4 Receptors Are Not Involved in the Effects of Fluoxetine in the Corticosterone Model of Depression. ACS Chemical Neuroscience, 12(11), 2036-2044.
+ Open protocol
+ Expand
3

Pharmacological Agents in Cardiovascular Study

Check if the same lab product or an alternative is used in the 5 most similar protocols
The compounds used in the present study were obtained from the following sources: sodium pentobarbital (Dolethal®; Vetoquinol; Madrid, Spain); fluoxetine hydrochloride was from Normon (Madrid, Spain); heparin sodium from Rovi (Madrid, Spain); alloxan monohydrate, 5-HT, 1-phenylbiguanide (1-PBG), 7-trifluoromethyl-4-(4-methyl-1-piperazinyl)pyrrolol [1,2-a]-quinoxaline dimaleate (CGS-12066B), ACh chloride and atenolol were from Merck Life Sciences S.L.U. (Madrid, Spain); 5-carboxamidotryptamine maleate (5-CT), α-methyl-5-hydroxytryptamine maleate (α-methyl-5-HT), 8-hydroxy-2-dipropylaminotetralin hydrobromide (8-OH-DPAT), 2-[5-[3-(4-methylsulfonylamino)benzyl-1,2,4-oxadiazol-5-yl]-1H-indol-3-yl]ethanamine (L-694,247), (R)-3-[2-[2-(4-methylpiperidin-1-yl)ethyl]pyrrolidine-1-sulfonyl]phenol hydrochloride (SB269970) and 1-[2-[4-(4-fluorobenzoyl)-1-piperidinyl]ethyl]-1,3-dihydro-3,3-dimethyl-2H-indol-2-one hydrochloride (LY310762) were from Tocris Bioscience (Bristol, UK). All drugs were dissolved in physiological saline at the time of experimentation, which had no effect on basal MBP or HR. The doses of all drugs refer to their free base.
García-Domingo M., García-Pedraza J.Á., Fernández-González J.F., López C., Martín M.L, & Morán A. (2022). Fluoxetine Treatment Decreases Cardiac Vagal Input and Alters the Serotonergic Modulation of the Parasympathetic Outflow in Diabetic Rats. International Journal of Molecular Sciences, 23(10), 5736.
+ Open protocol
+ Expand

About PubCompare

Our mission is to provide scientists with the largest repository of trustworthy protocols and intelligent analytical tools, thereby offering them extensive information to design robust protocols aimed at minimizing the risk of failures.

We believe that the most crucial aspect is to grant scientists access to a wide range of reliable sources and new useful tools that surpass human capabilities.

However, we trust in allowing scientists to determine how to construct their own protocols based on this information, as they are the experts in their field.

Ready to get started?

Sign up for free.
Registration takes 20 seconds.
Available from any computer
No download required

Sign up now

Revolutionizing how scientists
search and build protocols!