Biograph horizon pet ct

Manufactured by Siemens

The Biograph Horizon PET/CT is a medical imaging device that combines positron emission tomography (PET) and computed tomography (CT) technologies. It is designed to capture detailed images of the human body for diagnostic and treatment planning purposes.

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Lab products found in correlation

Exact hr tomograph, by Siemens (2 mentions) Matlab, by MathWorks (2 mentions) Spm12, by MathWorks (1 mentions)

Close spelling variants of this product

Biograph Horizon TrueV FDG-PET/CT system Biograph Horizon

2 protocols using biograph horizon pet ct

Amyloid Burden Quantification using PiB-PET

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Participants in the Aβ chronicity subsample underwent T1‐weighted magnetic resonance imaging (MRI) for anatomical delineation and [C‐11]PiB‐PET for the quantification of cerebral Aβ. Details regarding radioligand synthesis, image acquisition, processing, and analysis of MRI and PiB‐PET images have been described previously.²⁷ Amyloid burden was quantified as the average cortical PiB distribution volume ratio (DVR; Logan graphical analysis, cerebellum gray matter reference region) using dynamic PiB data acquired 0‐70 minutes post‐injection with either a Siemens Biograph Horizon PET/CT or Siemens EXACT HR+ tomograph. MRI and PET image processing and quality control were performed using a pipeline that uses MATLAB (The Mathworks, Inc., Natick, MA) and SPM12 (www.fil.ion.ucl.ac.uk/spm). The cut‐point for PiB positivity was a global DVR of 1.19.²⁸

Ennis G.E., Koscik R.L., Ma Y., Jonaitis E.M., Van Hulle C.A., Betthauser T.J., Randall A.M., Chin N., Engelman C.D., Anderson R., Suridjan I., Kollmorgen G., Christian B.T., Carlsson C.M., Asthana S., Johnson S.C., Zetterberg H., Blennow K, & Bendlin B.B. (2021). Insulin resistance is related to cognitive decline but not change in CSF biomarkers of Alzheimer's disease in non‐demented adults. Alzheimer's & Dementia : Diagnosis, Assessment & Disease Monitoring, 13(1), e12220.

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Multimodal Imaging of Tau and Amyloid

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¹⁸F-MK-6240 and ¹¹C-Pittsburgh Compound B (PiB) were used to quantify aggregated tau and cortical β-amyloid, respectively, using previously published methods [46 (link), 47 (link)]. PET data were collected using either a Siemens Biograph Horizon PET/CT or Siemens EXACT HR+ tomograph. Dynamic data were acquired for 20 min (5 min × 4 frames) following a 70-min uptake period for MK-6240 and 0–70 min (2 min × 5 frames, 5 min × 12 frames) beginning with tracer injection for PiB. T1-weighted magnetic resonance imaging (MRI) was performed to delineate anatomical regions. MRI and PET image processing and quality control were performed using a pipeline that uses MATLAB (The Mathworks, Inc., Natick, MA) and SPM12 (University College London). Details regarding radioligand synthesis, image acquisition, processing, and analysis of MRI, MK-6240 PET images [46 (link)], and PiB PET images [47 (link)] have been previously described.

Ennis G.E., Betthauser T.J., Koscik R.L., Chin N.A., Christian B.T., Asthana S., Johnson S.C, & Bendlin B.B. (2023). The relationship of insulin resistance and diabetes to tau PET SUVR in middle-aged to older adults. Alzheimer's Research & Therapy, 15, 55.

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