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Her3 py1289

Manufactured by Cell Signaling Technology
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HER3 pY1289 is a laboratory reagent used for the detection and quantification of phosphorylation at tyrosine 1289 of the HER3 protein. It is intended for research use only.

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Lab products found in correlation

Total her2, by Cell Signaling Technology (2 mentions) Anti α tubulin, by Merck Group (1 mentions) Erk1 2 pt202 py204, by Cell Signaling Technology (1 mentions) Alexa fluor 488 conjugated anti her3 antibody, by R&D Systems (1 mentions) Ps473 akt, by Cell Signaling Technology (1 mentions) Pt202 y204 erk, by Cell Signaling Technology (1 mentions) Py1173 egfr, by Cell Signaling Technology (1 mentions) Egfr py1068, by Cell Signaling Technology (1 mentions) Capmatinib, by Selleck Chemicals (1 mentions) Entrectinib, by Selleck Chemicals (1 mentions) Afatinib, by Selleck Chemicals (1 mentions) Crizotinib, by Selleck Chemicals (1 mentions) Total egfr, by Cell Signaling Technology (1 mentions)

2 protocols using her3 py1289

1

Signaling Pathways in Cancer Cell Lines

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NRG1 was purchased from PeproTech. Lapatinib was a kind gift from Professor György Kéri (Vichem Chemie Research Ltd Hungary). Bosutinib was purchased from LC Labs. Total HER2, HER3, PKB, HER2 pY877, HER3 pY1289, PKB pS473 and ERK1/2 pT202/pY204 antibodies were purchased from Cell Signaling Technology, anti-α-tubulin from Sigma, total ERK1/2 from Merck, and Alexa Fluor-488 conjugated anti-HER3 antibody from R&D systems.
Claus J., Patel G., Autore F., Colomba A., Weitsman G., Soliman T.N., Roberts S., Zanetti-Domingues L.C., Hirsch M., Collu F., George R., Ortiz-Zapater E., Barber P.R., Vojnovic B., Yarden Y., Martin-Fernandez M.L., Cameron A., Fraternali F., Ng T, & Parker P.J. (2018). Inhibitor-induced HER2-HER3 heterodimerisation promotes proliferation through a novel dimer interface. eLife, 7, e32271.
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2

Molecular Profiling of Receptor Tyrosine Kinases

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Entrectinib, crizotinib, capmatinib, and afatinib were purchased from Selleck Chemicals. Antibodies to total AKT, AKT pS473, total ERK, ERK pT202/Y204, total ROS1, ROS1 pY2274, total MET, MET pY1234/1235, total AXL, total EGFR, EGFR pY1068, EGFR pY1086, EGFR pY1173, total HER2, HER2 pY1196, HER2 pY1221/1222, HER3 pY1289 were purchased from Cell Signaling Technologies. Antibody to GAPDH was purchased from Santa Cruz Biotechnologies Inc. MET and CEP7 interphase FISH probes were purchased from Abbott Molecular Inc. MET, CEP7, MYC, and CEP8 metaphase FISH probes were purchased from Empire Genomics.
Tyler L.C., Le A.T., Chen N., Nijmeh H., Bao L., Wilson T.R., Chen D., Simmons B., Turner K.M., Perusse D., Kasibhatla S., Christiansen J., Dudek A.Z, & Doebele R.C. (2022). MET gene amplification is a mechanism of resistance to entrectinib in ROS1+ NSCLC. Thoracic Cancer, 13(21), 3032-3041.
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