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Levofloxacin

Manufactured by Abbvie
Sourced in United States

Levofloxacin is a synthetic antibiotic belonging to the fluoroquinolone class. It functions as a broad-spectrum antimicrobial agent, inhibiting bacterial DNA gyrase and topoisomerase IV, which are essential for bacterial cell division and replication.

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3 protocols using levofloxacin

1

Ocular Responses in Type 2 Diabetes

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Totally 80 T2DM patients and 150 non-diabetic controls were consecutively recruited from January to June in 2019. The inclusion criteria were T2DM patients with a controlled and stable blood glucose (fasting blood-glucose <8.3 mmol/L or HbA1c level ≤ 7%), and free of systemic administration or topical use of eyedrops for at least 3 months prior to their initial visit. They were further divided into two subgroups according to the duration of diabetes (<15 vs. ≥15 years). All participants are among Han ethic group and are from eastern China. The exclusion criteria were patients with histories of lacrimal or blepharal diseases, corneal or conjunctival disorders, glaucoma, contact lens wearing, history of eye surgeries or with other systematic diseases other than T2DM.
Among these patients, T2DM and non-diabetic controls who were scheduled for cataract surgeries were further followed up twice: one after 3 days of topical application of 0.5% levofloxacin preoperatively (Cravit, Santen, Japan; three times a day), and the other at 7 days after ceasing all postoperative medications of cataract surgery, including 0.5% levofloxacin three times a day for 2 weeks, 1% Prednisolone acetate ophthalmic suspension (Pred Forte, Allergan, Ireland) three times a day for 2 weeks, and Diclofenac sodium eye drops (Difei, Sinqi, China) three times a day for 4 weeks.
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2

Femtosecond Laser-Assisted SMILE and LASIK Procedures

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SMILE was performed using VisuMax femtosecond laser system (Carl Zeiss Meditec, Jena, Germany) with a repetition rate of 500 kHz and a pulse energy of 130 nJ. Lenticule diameter was set to 6 mm. The intended corneal cap thickness was set to 100–120 μm with a diameter of 7.5 mm. The procedure is described previously.10 (link)
In the FS-LASIK procedures, the same femtosecond laser system was used for flap creation with a pulse energy of 185 nJ, followed by a MEL 80 excimer laser (Carl Zeiss Meditec, Oberkochen, Germany) for stromal ablation with a repetition rate of 250 Hz and a pulse energy of 1.00±0.15 mJ. The intended flap thickness was set to 100 μm with a diameter of 8 mm. The hinges were located at a superior 12 o’clock with a length of 4.0 mm.
All surgeries were performed by an experienced surgeon (XTZ). Prior to surgery, 0.5% topical levofloxacin (Cravit; Santen, Osaka, Japan) was applied four to six times daily for 3 days. A bandage soft contact lens was applied for 1 day after FS-LASIK. After both procedures, 0.5% topical levofloxacin, 0.1% fluorometholone solution and non-preserved artificial tears (carboxymethylcellulose sodium eye drops; Allergan, Irvine, California, USA) were applied.
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3

Topical Medication Regimen for Postoperative Care

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The following topical medication regimen was prescribed: levofloxacin eye drops and prednisolone acetate (Allergan, Irvine, CA, USA) eye drops, 4 times/day for 2 weeks; pranoprofen eye drops (Senju Pharmaceutical Ltd., Osaka, Japan), 4 times/day for 1 month. 2 patients were prescribed with Timolol (Wujing, Wuhan, China) for IOP control, 2 times/day for 3 months. Postoperative examinations and data collection were performed as mentioned in previous section.
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