The imaging data of all participants were obtained using a 3.0 T Discovery MR 750 scanner (General Electric, Waukesha, WI, USA) at the Affiliated Hospital of Hangzhou Normal University. Participants were instructed to keep their eyes closed and remain still without focusing on any specific thoughts while staying awake during the scanning process. To minimize motion artifacts, a pair of stabilizers was utilized to immobilize the participants' heads. Functional images were acquired in an interleaved manner using a T2*-weighted gradient-echo EPI pulse sequence. The acquisition parameters were as follows: repetition time (TR) = 2000 ms, echo time (TE) = 22 ms, flip angle = 77°, field of view (FOV) = 240 × 240 mm2, matrix = 96 × 96, isotropic spatial resolution of 2.5 mm with 42 slices and a total of 240 volumes. High-resolution T1-weighted anatomical images were obtained in sagittal orientation for visualization and localization purposes using a fast spoiled gradient echo sequence (3D FSPGR): TR = 9 ms, TE = 3.66 ms, flip angle = 13°, field of view (FOV) = 240 × 240 mm2, matrix = 300 × 300, 0.8 mm isotropic voxels, 176 slices without interslice gap.
3.0 t discovery mr750 scanner
Manufactured by GE Healthcare
Sourced in United States
The 3.0-T Discovery MR750 scanner is a magnetic resonance imaging (MRI) system designed and manufactured by GE Healthcare. It operates at a magnetic field strength of 3.0 Tesla, which allows for high-quality imaging and fast scan times. The scanner is capable of acquiring detailed images of the human body, which can be used for various medical purposes, such as diagnostic imaging and monitoring of medical conditions.
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5 protocols using 3.0 t discovery mr750 scanner
1
Resting-State fMRI Acquisition Protocol
2
Multi-center PET and MRI Imaging Protocol
3
MRI Imaging Protocol for Dynamic Contrast Enhancement
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MRI was performed with a 3.0 T Discovery MR 750 scanner (GE Healthcare, Waukesha, WI, United States). (1) The following parameters were used for fat-suppressed fast spin-echo T2-weighted imaging (T2WI): repetition time (TR)/echo time (TE), 12000/72 ms; matrix size, 320 × 320; field of view (FOV), 360 × 360 mm2; slice thickness, 3 mm; spacing between slices, 0.6 mm; number of excitation (NEX), 2; and bandwidth, 83.3 kHz. (2) Gd-diethylenetriamine pentaacetic acid (Gd-DTPA) was injected at a dose of 0.1 mmol/kg through the median cubital vein at an injection rate of 2.0 mL/s, followed by 15 ml of saline at the same flow rate. A fat-suppressed T1-weighted three-dimensional (3D) gradient-recalled-echo sequence was used to collect dynamic enhanced images with the following parameters: TR/TE, 4.1/1.2 ms; matrix size, 260 × 240; FOV, 360 × 360 mm2; slice thickness, 3 mm; spacing between slices, 0 mm; NEX, 1; and bandwidth, 142.8 kHz. The late arterial phase (LAP), portal venous phase (PVP), and delayed phase (DP) were acquired at 25 seconds, 45 seconds, and 80 seconds. Other scanning sequence conditions not used for radiomics are not listed in this study.
4
Multimodal Neuroimaging Acquisition Protocol
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Imaging data of all subjects were gathered from the 3.0 T Discovery MR 750 scanner (General Electric, Waukesha, WI, USA) at the Center for Cognition and Brain Disorders at Hangzhou Normal University. The subjects were asked to keep relaxed with their eyes closed but not fall asleep and keep motionless during the scanning as much as possible. In order to stabilize the head and reduce movement, pair of stabilizers were used to immobilize subjects’ heads. Functional images were collected in an interleaved order using a T2*-weighted gradient-recalled echo-planar-imaging (EPI) sequence. Detailed collection parameters were as follows: echo time (TE)= 22 ms, flip angle=77°, repetition time (TR)=2,000 ms, matrix=96×96, field of view (FOV)=240×240 mm2 , 2.5 mm isotropic spatial resolution with 42 slices and 240 volumes. Highresolution T1-weighted anatomical images were received in sagittal orientation for visualization and localization of the functional images with fast spoiled gradient echo sequence (3D): TE=3.66 ms, flip angle=13°, TR=9 ms, matrix=300×300, FOV=240×240 mm2, 0.8 mm isotropic voxels, 176 slices without interslice gap.
5
PET/MRI Imaging Protocols for Neurological Disorders
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The PET images were acquired using a Biograph micro-CT PET/CT scanner (Siemens Medical Solutions) in the Memory Disorder Clinic of Gangnam Severance Hospital, Discovery 690 PET scanner (GE Medical Systems) in the BioFINDER study, and a Biograph 6 Truepoint PET/CT scanner (Siemens Medical Solutions) for UCSF patients. The PET data were locally reconstructed into 4- × 5-minute frames for the 80- to 100-minute interval after injection.15 (link),24 (link),25 (link) The MRIs were acquired on a 3.0-T Discovery MR750 scanner (GE Medical Systems) in the Memory Disorder Clinic of Gangnam Severance Hospital, 3.0-T Tim Trio or Skyra scanner (Siemens Medical Solutions) in the BioFINDER study, and a 3.0-T Tim Trio or Prisma scanner (Siemens Medical Solutions) at UCSF.
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