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Quinine hemisulfate salt monohydrate

Manufactured by Merck Group
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Quinine hemisulfate salt monohydrate is a chemical compound used in laboratory settings. It is a white crystalline powder that serves as a precursor or intermediate in various chemical reactions and processes. The compound has a well-defined molecular structure and physical properties that make it useful for specific laboratory applications, but a detailed description of its core function is not available without the risk of interpretation or extrapolation.

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Lab products found in correlation

Amodiaquine dihydrochloride dihydrate, by Merck Group (1 mentions) Chloroquine diphosphate salt, by Merck Group (1 mentions) Saccharin sodium salt hydrate, by Merck Group (1 mentions) Sodium chloride (nacl), by Thermo Fisher Scientific (1 mentions) Sodium chloride (nacl), by Merck Group (1 mentions) Sodium chloride (nacl), by Baxter (1 mentions) Hybri max, by Merck Group (1 mentions) Sucrose, by Merck Group (1 mentions) Sodium hydride, by Merck Group (1 mentions) Acetophenone, by Merck Group (1 mentions) Hydrazine hydrate, by Merck Group (1 mentions) Magnesium sulfate, by Merck Group (1 mentions) Chloroform d, by Merck Group (1 mentions) 4 acetylpyridine, by Merck Group (1 mentions) 4 methoxyacetophenone, by Merck Group (1 mentions) 2 picolinic acid, by Merck Group (1 mentions) 4 bromoacetophenone, by Merck Group (1 mentions) Chloroform, by Merck Group (1 mentions) Ethanol, by Merck Group (1 mentions) Dmso d6, by Merck Group (1 mentions)

6 protocols using quinine hemisulfate salt monohydrate

1

Preparing Methamphetamine and Quinine Solutions

Cited 1 time
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Ten mg of mAMPH or 5.6025 mg of quinine hemisulfate salt monohydrate (Sigma, St. Louis, MO) was dissolved in 1 liter of H20. Due to the bitter taste of mAMPH, the quinine tastant was used to ensure that taste could not account for a difference in consumption of the mAMPH between the adolescent exposure groups. These concentrations were reduced from those used in mice to account for somewhat greater drug sensitivity of rats, and to avoid rejection that can occur at higher concentrations (Shabani et al., 2011 (link)).
Ye T., Pozos H., Phillips T.J, & Izquierdo A. (2014). Long-term effects of exposure to methamphetamine in adolescent rats. Drug and alcohol dependence, 138, 17-23.
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2

Kinetic Analysis of Antimalarial Drugs

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Quinine hemisulfate
salt monohydrate (Sigma), amodiaquine dihydrochloride dihydrate (Sigma),
and chloroquine diphosphate salt (Sigma) were diluted in TE140 running
buffer (10 mM Tris–HCl, 140 mM NaCl, 0.05% Tween20, 50 μM
EDTA, 50 μM EGTA, pH 7.4). The flow rate for the association
of analyte was 200 μL/min for 20 s and 500 μL/min during
60 s long dissociation, with a sampling rate of 20 Hz. No regeneration
of the surface was required due to the complete dissociation of the
analyte.
Higuera-Rodriguez R.A., De Pascali M.C., Aziz M., Sattler M., Rant U, & Kaiser W. (2023). Kinetic FRET Assay to Measure Binding-Induced Conformational Changes of Nucleic Acids. ACS Sensors, 8(12), 4597-4606.
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3

Ethanol and Pharmacological Solutions

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The ethanol solution for injections (20% v/v, administered intraperitoneally -i.p.-) was prepared diluting 200-proof ethanol (Pharmco-Aaper Inc., Brookfield, CT) in isotonic saline. Ethanol solutions for drinking experiments (3%, 6%, 10% and 20% v/v) were prepared using 190-proof ethanol and tap water. Saccharin (0.02% and 0.07% w/v), quinine (0.03 and 0.1 mM) and sodium chloride (NaCl, 0.2 M) solutions were prepared dissolving saccharin sodium salt hydrate, quinine hemisulfate salt monohydrate (both from Sigma, St. Louis, MO), and sodium chloride (Fisher Scientific, Agawam, MA), respectively, in tap water.
The partial inverse agonist of the benzodiazepine (BDZ) receptor Ro 15-4513 (R&D Systems, Inc., Minneapolis, MN) was dissolved in DMSO (10% v/v) and then diluted with isotonic saline. Ro 15-4513 was injected i.p. in a volume of 10 ml/kg.
Valenza M., DiLeo A., Steardo L., Cottone P, & Sabino V. (2015). Ethanol-related behaviors in mice lacking the sigma-1 receptor. Behavioural brain research, 297, 196-203.
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4

DREADD-Mediated Neuronal Manipulation in Mice

Cited 2 times
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Mice received injections (i.p.) of either vehicle [1% DMSO (Hybri-Max, Sigma Life Sciences, MO, USA) in 0.09% NaCl (Baxter International, Il, USA)] or 1 mg/kg CNO (RTI International, NC, USA; in vehicle) in a volume of 10mL/kg (a 20g mouse received 0.2mL injection). This dose of CNO was selected for its ability to successfully stimulate DREADDs without being back-converted to physiologically relevant levels of clozapine (Jendryka et al., 2019 (link); Purohit et al., 2018 (link)).
Ethanol (EtOH; Decon Laboratories, Inc., PA, USA) used for DID was diluted to 20% in tap water (v/v). Sucrose (Sigma Life Sciences, MO, USA) was dissolved in tap water to make 2.5% and 5% solutions (w/v). Quinine hemisulfate salt monohydrate (Sigma Life Science, MO, USA) was dissolved in tap water to reach concentrations of 0.03 mM and 0.06 mM.
Townsley K.G., Borrego M.B, & Ozburn A.R. (2020). Effects of chemogenetic manipulation of the nucleus accumbens core in male C57BL/6J mice. Alcohol (Fayetteville, N.Y.), 91, 21-27.
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5

Synthesis of 1,3-Diketones from Methyl Picolinate

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2-Picolinic acid (98-98-6), sulphur acid (7664-93-9), sodium bicarbonate (144-55-8), sodium hydride (7646-69-7), 6-methoxy 2-acetonaphthone (3900-45-6), 4-bromo acetophenone (99-90-1), acetophenone (98-86-2), 4-methoxy acetophenone (100-06-1), 4-acetylPyridine (1122-54-9), 2-acetyl anthracene (784-04-3), magnesium sulfate (7487-88-9), hydrazine hydrate (10,217-52-4), triphenyl borane (960-71-4), quinine hemisulfate salt monohydrate (207,671-44-1), sodium chloride (7647-14-5), silica (112,926-00-8), molecular sieves 4A0 (20,300), methanol (67-56-1), dichloromethane (75-09-2), tetrahydrofuran (109-99-9), Pyridine (110-86-1), chloroform (67-66-3), ethanol (64-17-5), chloroform-d (865-49-6), DMSO-d6 (2206-27-1) were purchased from Sigma Aldrich, Australia. Methyl picolinate used for the synthesis of 1,3-diketones was synthesized according to a reported method57 (link).
Javaid R., Rehman A.U., Ahmed M., Karouei M.H, & Sayyadi N. (2022). Synthesis and photophysical investigations of pyridine-pyrazolate bound boron(III) diaryl complexes. Scientific Reports, 12, 16482.
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6

Synthesis of Composite Nanoparticles

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CA monohydrate (≥99.0%), polyethylene glycol dodecyl ether (Brij L4), tetraethyl orthosilicate (TEOS) (≥98.0%), ammonia solution 28–30% (≥99.0%), N1-(3-Trimethoxysilylpropyl) diethylenetriamine (DETAS), quinine hemisulfate salt monohydrate, and ethanol absolute (≥99.8%) were purchased from Sigma-Aldrich (Hoeilaart, Belgium). Hexane (≥99.0%) was purchased from Chimmed (Russia). Carboxyethylsilanetriol sodium salt (CEST) 25% in water was purchased from ABCR (Germany). The used water for the experiments was double-distilled.
Stainless steel autoclaves, ultrasonic bath, centrifuge, and dialysis bags (MWCO = 1000 Da) were used for the synthesis and purification of composite nanoparticles.
Podkolodnaya Y.A., Kokorina A.A, & Goryacheva I.Y. (2022). A Facile Approach to the Hydrothermal Synthesis of Silica Nanoparticle/Carbon Nanostructure Luminescent Composites. Materials, 15(23), 8469.
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