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Nan 190

Manufactured by Bio-Techne
Sourced in United Kingdom

NAN-190 is a chemical compound used in research applications. It functions as a selective antagonist of the 5-HT1A receptor. The compound is typically utilized in experimental studies to investigate the role of the 5-HT1A receptor in various biological processes.

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3 protocols using nan 190

1

Pharmacological Modulation of Synaptic Transmission

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Drugs including 5-Hydroxytryptamine (5-HT), DNQX, 8-hydroxy-2-dipropylaminotetralin hydrobromide (8-OH-DPAT), N-(piperidin-1-yl)-5-(4-iodophenyl)-1-(2,4-dichlorophenyl)-4-methyl-1H-pyrazole-3-carboxamide (AM251), D-AP5, 1-(m-chlorophenyl) biguanide hydrochloride (mCPBG), NAN-190, ketanserin, and 1,2-bis(2-aminophenoxy)ethane-N,N,N',N'-tetraacetic acid (BAPTA) were purchased from Tocris Bioscience (Bristol, UK). ondansetron hydrochloride, α-methyl-5-hydroxytryptamine (α-me-5-HT), CCh, and atropine were purchased from Sigma-Aldrich (St Louis, MO, USA). BAPTA was included in the pipette solution. NAN-190 and AM251 were dissolved in dimethyl sulfoxide (DMSO, 0.1%).
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2

Pharmacological Reagents for Neuroscience Research

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The PKA inhibitor 6~22 amide (PKI) was purchased from Calbiochem (La Jolla, CA). DNQX, D-AP5, ifenprodil, bicuculline, 2-me-5-HT, NAN-190, 8-hydroxy-N,N-dipropyl-2-aminotetralin (DPAT), and 2,5-dimethoxy-4-iodoamphetamine (DOI) were purchased from Tocris (Bristol, UK). The other chemicals were purchased from Sigma (St. Louis, MO, USA).
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3

Preparation of Drug Solutions

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5-HT and guanosine-5′-O-(2-thiodiphosphate) (GDP-β-S) were obtained from Sigma–Aldrich (St. Louis, MO, USA). NAN-190, picrotoxin and tetrodotoxin were purchased from Tocris Cookson (Bristol, UK). Drugs were prepared as stock solutions for frozen aliquots at −20 °C. All these drugs were diluted from the stock solution to the final desired concentration in the artificial cerebrospinal fluid (ACSF) before immediate use. All of other chemicals and reagents used were commercially available and of standard biochemical quality.
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