2 bromoisobutyryl bromide

Manufactured by Thermo Fisher Scientific

Sourced in Belgium, China, United Kingdom, United States

2-bromoisobutyryl bromide is a chemical compound commonly used as a reagent in organic synthesis. It is a clear, colorless liquid with a pungent odor. The core function of 2-bromoisobutyryl bromide is to serve as a versatile acylating agent, enabling various chemical transformations and reactions.

Automatically generated - may contain errors

Lab products found in correlation

6 protocols using 2 bromoisobutyryl bromide

Atom Transfer Radical Polymerization

Check if the same lab product or an alternative is used in the 5 most similar protocols

Copper powder (Cu(0), 99.5%, 150 mesh), copper(I) chloride (CuCl, 97%), copper(I) bromide (CuBr, 99%), N,N,N′,N″,N″-pentamethyldiethylenetriamine (PMDETA), alumina (Al₂O₃ neutral), benzyl alcohol (BzOH), 4-vinylbenzyl chloride (VBC), styrene (St), and tert-butyl acrylate (tBA, 98%) were purchased from Sigma–Aldrich (St. Louis, MO, USA) . 2-Bromoisobutyryl bromide (BiB, 97%), ε-caprolactone (CL, 98%), tin(II) 2-ethylhexanoate (Sn(oct)₂), and triethylamine (TEA, 99.5%) were purchased from Acros (Geel, Belgium). All solvents and monomers were purified and stored with dried molecular sieves prior to use.

Sathesh V., Chen J.K., Chang C.J., Aimi J., Chen Z.C., Hsu Y.C., Huang Y.S, & Huang C.F. (2018). Synthesis of Poly(ε-caprolactone)-Based Miktoarm Star Copolymers through ROP, SA ATRC, and ATRP. Polymers, 10(8), 858.

+ Open protocol

+ Expand

Synthesis of Clickable Hyperbranched Polyester

Check if the same lab product or an alternative is used in the 5 most similar protocols

Hyperbranched polyester initiator, 220P, with an M_n of ca. 1600 g/mol (Weihai CY Dendrimer Technology Co., Ltd), mono-methoxyl PEG with an M_n of ca. 2000 g/mol (Aldrich), ε-caprolactone (CL, Acros, 99%), stannous octoate (Sn(Oct)₂, Aladdin, 95%), 4-pentynoic acid (J&K Scientific Ltd., 95%), N, N-dicyclohexylcarbodiimide (DCC, J&K Scientific Ltd., 99%), 4-dimethylaminopyridine (DMAP, TCI, 99%), 2-bromoisobutyryl bromide (Acros, 98%), trimethylamine (TCI, Shanghai, 99%), tris(2-dimethylaminoethyl)amine (ME6-TRAN, Alfa Aesar, 99%), N,N,N′,N″,N″-pentamethyldiethylenetriamine (PMDETA, Aldrich, 99%), dichloromethane (CH₂Cl₂, J&K Scientific Ltd., 99.8%), Ethylenediaminetetraacetic acid disodium salt (EDTA-2Na, J&K Scientific Ltd.) and N,N-dimethylformamide (DMF, J&K Scientific Ltd., 99.9%) were used as received. 2-diethylaminoethyl methacrylate (DEAEMA, J&K Scientific Ltd., 99.5%) was purified by passing through a basic alumina column. Copper (I) bromide (CuBr, J&K Scientific Ltd., 98%) was purified by stirring with acetic acid overnight, filtered, and then successively washed with acetone and ethanol until it turned white, followed by complete drying in a vacuum oven at room temperature. Other solvents were purchased from Beijing Chemical Reagent Co. Ltd (China) and used as received. Deionized and distilled water was utilized throughout the study.

Feng A., Liang J., Ji J., Dou J., Wang S, & Yuan J. (2016). CO2-breathing and piercing polymersomes as tunable and reversible nanocarriers. Scientific Reports, 6, 23624.

+ Open protocol

+ Expand

Synthesis of Functional Polymeric Materials

Check if the same lab product or an alternative is used in the 5 most similar protocols

Poly(ethylene glycol) (95%, PEG, M_W = 2000, 4000, 8000, and 10,000 g·mol⁻¹) was dried under high vacuum. Before use in experiments, 2-(2-methoxyethoxy) ethyl methacrylate (MEO₂MA, 95%, M_n = 188 g·mol⁻¹), oligo(ethylene glycol) methacrylate (OEGMA, 95%, M_n = 475 g·mol⁻¹), and (N,N-diethylamino) ethyl methacrylate (DEAEMA, 98%, M_n = 185 g·mol⁻¹) (J&K Chemical Technology Co., Ltd., Beijing, China) were purified by distillation. Copper (I) chloride (Cu(I)Cl, 99.999%) (Alfar, Shanghai, China), 2,2-bipyridine (bpy, 99%) and the ATRP initiator 2-bromoisobutyryl bromide (98%, Acros, Beijing, China) were used as received. BSA was obtained from Sigma-Aldrich (Shanghai, China). Toluene was dried with metallic sodium, distilled, and stored in a solvent storage flask. Anhydrous ether, methanol (CH₃OH) purified by distillation, tetrahydrofuran (THF), and dichloromethane (CH₂Cl₂) were purchased from Shanghai Chemical Reagent (Shanghai, China). All other chemicals were purchased from either Shanghai Chemical Reagent or J&K and used without further purification.

Han Y., Liu S., Mao H., Tian L, & Ning W. (2016). Synthesis of Novel Temperature- and pH-Sensitive ABA Triblock Copolymers P(DEAEMA-co-MEO2MA-co-OEGMA)-b-PEG-b-P(DEAEMA-co-MEO2MA-co-OEGMA): Micellization, Sol–Gel Transitions, and Sustained BSA Release. Polymers, 8(11), 367.

+ Open protocol

+ Expand

Synthesis and Characterization of Polymer Precursors

Check if the same lab product or an alternative is used in the 5 most similar protocols

Propargyl alcohol (99%; Shanghai Jing-Chun Co., Ltd.) was dried over anhydrous magnesium sulfate, then was distilled under reduced pressure. Methylbenzene and tetrahydrofuran were refluxed by sodium metal and distilled under ordinary pressure before use. ε-Caprolactone (CL, 99%; Acros Organic) was distilled over CaH₂ and stored under N₂ before use. l-Lactide (LLA; Shanghai Tong-Jie-Liang Biomaterials Co., Ltd.) was purified by twice recrystallization from ethyl acetate and dried in a vacuum at room temperature. Tin 2-ethylhexanoate (Sn(Oct)₂; Aldrich, USA) was distilled under reduced pressure before use. Cuprous bromide (CuBr, ≥98.5%) was wash to colorless with acetic acid, washed three times with anhydrous ethanol and anhydrous ether and dried in a vacuum. Sodium nitride (NaN₃, 99%; Shanghai Jing-Chun Co., Ltd.), 2-bromoisobutyryl bromide (97%; Alfa Aesar, UK) and N,N,N′,N′,N′′-pentamethyldiethylene triamine (PMDETA, 98%; Alfa Aesar, UK) and Merrifield resin (BR; Shanghai Ju-Yuan Biomaterials Co., Ltd.) were used as received without further purification. Pentaerythritol (PENTA, ≥99%; Aldrich, USA) was dried in a vacuum at 60 °C. Pyridine was distilled over KOH before use. All other chemicals were of analytical grade, and purchased from Sinopharm Chemical Regent Company.

Yan X., Li J, & Ren T. (2018). Synthesis of well-defined star, star-block, and miktoarm star biodegradable polymers based on PLLA and PCL by one-pot azide–alkyne click reaction. RSC Advances, 8(51), 29464-29475.

+ Open protocol

+ Expand

Synthesis of Poly(γ-CD-g-HEMA) Copolymers

Check if the same lab product or an alternative is used in the 5 most similar protocols

γ-CD (Wako, Japan) and PPO-PEO-PPO (comprised of a central block of 90 PEO units and two flank blocks of 5 PO units having M_n = 4580 (Zhejiang Huangma Chemical Industry Group Co., Ltd, China)) were used as received without further purification. 2-Hydroxyethyl methacrylate (HEMA) (TCI, Japan) was passed over a short basic alumina column to remove the inhibitor before polymerization. N,N,N’,N”,N”-penta-methyldiethylenetriamine (PMDETA) and ethyl 2-bromoisobutyrate were purchased from Sigma, USA. Both 2-bromoisobutyryl bromide and 4-dimethylaminopyridine (DMAP) were available from Alfa Aesar, USA. Triethylamine (TEA) (VAS Chemical Reagents Company, China) was refluxed with p-toluenesulfonyl chloride and distilled under vacuum. Copper(I) chloride (Cu(I)Cl) was prepared from CuCl₂, purified by stirring in hydrochloric acid, washed with methanol and finally dried under vacuum prior to use. CH₂Cl₂ was stirred with CaH₂ and distilled under reduced pressure. DMF was supplied by Sinopharm Chemical Reagent Company, China and used without further purification. All other solvents and reagents were of analytical grade.

Kong T., Ye L., Zhang A.Y, & Feng Z.G. (2014). Loose-fit polypseudorotaxanes constructed from γ-CDs and PHEMA-PPG-PEG-PPG-PHEMA. Beilstein Journal of Organic Chemistry, 10, 2461-2469.

+ Open protocol

+ Expand

Preparation of Selenium-containing Polymer

Check if the same lab product or an alternative is used in the 5 most similar protocols

Propargyl alcohol (99%), 2–bromoisobutyryl bromide (97%), dimethylamino pyridine (DMAP, 99%), and copper wire (0.5 mm) were supplied by Alfa Aesar (Seoul, Korea). Glycidyl methacrylate, 1,4 dithio-D, L-threitol (DTT), Poly (ethylene glycol) methyl ether (average Mn 5000), trimethylamine, (97%), N, N′ dicyclohexylcarbodiimide (DCC), N,N,N′,N′,N′” pentamethyldiethylenetriamine (PMDETA), selenium powder, and sodium borohydride (NaBH₄) were supplied by Sigma-Aldrich (Seoul, Korea). The 3,3’-diselanediyldipropanoic acid (DSeDPA) was prepared following the method of previous work [25 (link)]. Acetonitrile, dimethylformamide, dichloromethane, ethyl acetate, and tetrahydrofuran, hydrogen peroxide 37% were ordered from Duksan Pure Chemical (Seoul, Korea).

Siboro S.A., Salma S.A., Kim H.R., Jeong Y.T., Gal Y.S, & Lim K.T. (2020). Diselenide Core Cross-Linked Micelles of Poly(Ethylene Oxide)-b-Poly(Glycidyl Methacrylate) Prepared through Alkyne-Azide Click Chemistry as a Near-Infrared Controlled Drug Delivery System. Materials, 13(12), 2846.

+ Open protocol

+ Expand

About PubCompare

Our mission is to provide scientists with the largest repository of trustworthy protocols and intelligent analytical tools, thereby offering them extensive information to design robust protocols aimed at minimizing the risk of failures.

We believe that the most crucial aspect is to grant scientists access to a wide range of reliable sources and new useful tools that surpass human capabilities.

However, we trust in allowing scientists to determine how to construct their own protocols based on this information, as they are the experts in their field.

Ready to get started?

Revolutionizing how scientists
search and build protocols!