Diclofenac na

Manufactured by Merck Group

Sourced in United States, India

Diclofenac-Na is a laboratory reagent used in various analytical procedures. It is the sodium salt of diclofenac, a non-steroidal anti-inflammatory drug (NSAID). Diclofenac-Na is commonly used as a chemical standard or reference material in analytical techniques such as spectrophotometry, chromatography, and other pharmaceutical testing applications.

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Diclofenac (210 citations)

6 protocols using diclofenac na

Reagent Procurement for Pharmacological Studies

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Reagent grade formalin and acetic acid were purchased from MERCK, India through Taj Scientific Ltd. Diazepam and diclofenac-Na were brought from Sigma-Aldrich, USA via local supplier. Morphine sulfate kindly donated by Popular Pharmaceuticals Ltd., Bangladesh. All other reagents were of analytical grade unless otherwise specified.

Uddin M.J., Ali Reza A.S., Abdullah-Al-Mamun M., Kabir M.S., Nasrin M.S., Akhter S., Arman M.S, & Rahman M.A. (2018). Antinociceptive and Anxiolytic and Sedative Effects of Methanol Extract of Anisomeles indica: An Experimental Assessment in Mice and Computer Aided Models. Frontiers in Pharmacology, 9, 246.

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Evaluation of Pharmacological Agents

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Formalin and acetic acid were obtained from Merck (India). DMSO and methanol were from Merck (Germany). Loperamide was from Square Pharmaceuticals Ltd, Bangladesh. Castor oil was from WELL’s Heath Care, Spain. Diclofenac‐Na was from Sigma‐Aldrich, USA. Analytical reagent grade chemicals were used for all experiments.

Ahmad S., Nasrin M.S., Reza A.S., Chakrabarty N., Hoque M.A., Islam S., Hafez Kabir M.S., Tareq S.M., Alam A.H., Haque M.A, & Arman M.S. (2020). Curculigo recurvata W.T.Aiton exhibits anti‐nociceptive and anti‐diarrheal effects in Albino mice and an in silico model. Animal Models and Experimental Medicine, 3(2), 169-181.

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Analgesic Efficacy Evaluation

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Diclofenac Na, formalin, and acetic acid were obtained from MERCK, India. Morphine sulfate and 0.9 % NaCl saline solution was obtained from Popular Pharmaceuticals Ltd., Bangladesh. Unless otherwise specified, all other reagents were of analytical grade.

Uddin M.J., Rahman M.M., Abdullah-Al-Mamun M, & Sadik G. (2015). Vanda roxburghii: an experimental evaluation of antinociceptive properties of a traditional epiphytic medicinal orchid in animal models. BMC Complementary and Alternative Medicine, 15, 305.

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Diclofenac and Nalbuphine Analgesic Protocol

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Diclofenac Na (MERCK, Mumbai, India), nalbuphine (Square Pharmaceuticals Ltd., Bangladesh), formaldehyde (MERCK, Mumbai, India), and 0.9% NaCl saline solution (Popular Pharmaceuticals Ltd., Bangladesh) were used. All other reagents were of analytical grade.

Chowdhury M.A., Rahman M.M., Chowdhury M.R., Uddin M.J., Sayeed M.A, & Hossain M.A. (2014). Antinociceptive and cytotoxic activities of an epiphytic medicinal orchid: Vanda tessellata Roxb.. BMC Complementary and Alternative Medicine, 14, 464.

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Evaluation of Antioxidant and Enzyme Inhibitory Activities

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Acarbose, AlCl₃ 6.H₂O, allopurinol, porcine pancreatic α-amylase (EC 3.2.1.1), 2,2-diphenyl-1-picrylhydrazyl (DPPH), Folin-Ciocalteu reagent, p-nitrophenyl α-D-glucopyranoside (p-NPG), Na-diclofenac, orlistat, rutin, protease (EC 3.4.23.6), xanthine, and xanthine oxidase from bovine milk (EC 1.17.3.2) were obtained from Sigma-Aldrich (St. Louis, USA). PBR322 plasmid DNA was obtained from BioLabs (Boston, USA). Ammonium molybdate, NaNO₂, and starch were purchased from Merck (Darmstadt, Germany). Gallic acid was purchased from Santa Cruz Biotechnology (Dallas, USA). All remaining reagents were of the highest purity available (>98%). All solvents were of analytical grade.

Simamora A., Santoso A.W., Timotius K.H, & Rahayu I. (2020). Antioxidant Activity, Enzyme Inhibition Potentials, and Phytochemical Profiling of Premna serratifolia L. Leaf Extracts. International Journal of Food Science, 2020, 3436940.

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Optimizing Diclofenac Extraction and Purification

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M ethanol (Merck), DMF (Merck), ethanol (Merck), Na diclofenac (Sigma-Aldrich), HCl (smart lab), Bovine serum albumin fraction V (Sigma-Aldrich), NaOH (Merck), Trizma Base (Sigma-Aldrich), NaCl (Merck), TLC plate 60 F254 (Merck).

Komala I., Supandi S., Thantow A., & Putra A.M.J. (2020). An Efficient Directly Conversion of the Ethyl p-Methoxycinnamate into N,N-dimethyl-p-Methoxycinnamamide and study the structure-activity relationship on anti-inflammatory activity. INDONESIAN JOURNAL OF PHARMACY.

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