ACAi-028 was purchased from ChemBridge (San Diego, CA, USA). AZT, PF74, and EFV were purchased from Sigma-Aldrich,
Ebselen from AdipoGen Life Sciences, and
AMD3100 from Selleck Chemicals.
Atazanavir (ATV) was kindly provided by Bristol Myers Squibb (New York, NY). and AIDS, and the grants from the Sumitomo Electric Group CSR Foundation (MA).
TN and MA designed and TC, TN, NT, and MA performed all the experiments. NT and MM discussed the data and supported preparation of the MS. MA and HN supervised, managed the project, and acquired the necessary funding. TC, TN, and MA wrote and MM and HN edited the MS. All authors read, commented on, and approved the final manuscript.
We declare that we have no conflicts of interest.
Chia T., Nakamura T., Amano M., Takamune N., Matsuoka M., & Nakata H. (2021). A small molecule, ACAi-028, with anti-HIV-1 activity targets a novel hydrophobic pocket on HIV-1 capsid.