The core CIMA‐Q protocol is referred to as the Canadian Dementia Imaging Protocol (www.cdip-pcid.ca ). All brain images were acquired from either Siemens Healthcare (TrioTim and Prisma Fit) or Philips Medical Systems (Achieva and Ingenia) scanners with a magnetic field of 3 Tesla (more details about the acquisition parameters can be found in supporting information). The protocol sequences for image acquisition were harmonized between manufacturers/software configurations to optimize commonality, and quality control procedures were performed monthly to ensure across‐scan comparability (see Duchesne et al.22 ).
Triotim
Manufactured by Philips
TrioTim is a compact and versatile lab equipment designed for precise temperature control. It features a digital display and intuitive controls, allowing users to set and monitor the temperature with accuracy. The core function of TrioTim is to provide a reliable and consistent thermal environment for various laboratory applications.
Automatically generated - may contain errors
4 protocols using triotim
1
Canadian Dementia Imaging Protocol
2
Healthy Brain Imaging Database Creation
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The scanner-specific single-scanner NDB (SSD) consisted of the 37 healthy controls from the test dataset.
The non-scanner-specific multiple-scanner NDB (MSD) comprised 3D T1-weighted MRI with 1 × 1 × 1 mm3 resolution from 164 subjects (64.1 ± 9.4 years, 57% females) acquired for unspecific symptoms (e.g., headache, dizziness) with 164 different MRI scanners at 164 different sites using acquisition sequences recommended by the scanner manufacturer. Imaging was performed at 3/1.5/1.0 Tesla in 47/114/3 cases (28.7/69.5/1.8%) using MRI scanners from three different manufacturers: Siemens (n = 110; Aera, Amira, Avanto, Espree, Galan, HarmonyExpert, MAGNETOM (Lumina, Vida, ESSENZA), Orian, Skyra (fit), Symphony (Tim), TrioTim, Verio), Philips (n = 40; Achieva (dStream), Ingenia, Intera, Panorama HFO), and GE (n = 14; DISCOVERY MR750, Optima MR450w, SIGNA (Hde, HDxt, Voyager)).
None of the patients had a history of or currently ongoing neurological or psychiatric disease. All scans were free of abnormalities beyond those expected for the patients’ age based on visual inspection by an experienced radiologist.
The non-scanner-specific multiple-scanner NDB (MSD) comprised 3D T1-weighted MRI with 1 × 1 × 1 mm3 resolution from 164 subjects (64.1 ± 9.4 years, 57% females) acquired for unspecific symptoms (e.g., headache, dizziness) with 164 different MRI scanners at 164 different sites using acquisition sequences recommended by the scanner manufacturer. Imaging was performed at 3/1.5/1.0 Tesla in 47/114/3 cases (28.7/69.5/1.8%) using MRI scanners from three different manufacturers: Siemens (n = 110; Aera, Amira, Avanto, Espree, Galan, HarmonyExpert, MAGNETOM (Lumina, Vida, ESSENZA), Orian, Skyra (fit), Symphony (Tim), TrioTim, Verio), Philips (n = 40; Achieva (dStream), Ingenia, Intera, Panorama HFO), and GE (n = 14; DISCOVERY MR750, Optima MR450w, SIGNA (Hde, HDxt, Voyager)).
None of the patients had a history of or currently ongoing neurological or psychiatric disease. All scans were free of abnormalities beyond those expected for the patients’ age based on visual inspection by an experienced radiologist.
3
Multi-site 3T MRI Scanning for Cognitive Impairment
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T1-weighted MRI scanning was performed at five different sites (see Table 1 ). Scans were acquired from either Siemens Healthcare (TrioTim and Prisma Fit) or Philips Medical Systems (Achieva and Ingenia) scanners with a magnetic field strength of 3 Tesla. All scans were first visually inspected by a rater blinded to the diagnosis. Six participants were excluded due to poor quality scans (CH = 1, SCD = 1, AD = 4). The final sample included 137 participants (CH = 29, SCD = 66, eMCI = 22, lMCI = 8, AD = 12).
4
Automatic MRI Series Labeling using ML
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Automatic labeling of MR series using ML methods on DICOM metadata was applied to the dataset available on the PRIMAGE platform. From the 558 patients available at the PRIMAGE platform (October 2022), 300 with an MR exam at diagnosis were selected. Cases with an MR performed after initial treatment with chemotherapy and tumoral rests were also included.
MR images accounted for a high data acquisition variability, including different institutions with large heterogeneity in scanner vendors, protocols, and tumor location. MR exams were acquired with a 1.5 Tesla (n = 435) or 3 Tesla (n = 100) scanners, manufactured by either General Electric Healthcare (Signa Excite HDxt, Signa Explorer, Discovery, Genesis; n = 105); Siemens Medical (Aera, Skyra, Symphony, Avanto, Magneto Espree, TrioTim, Sonata, Spectra, Verio, Harmony; n = 318); Philips Healthcare (Intera, Achieva, Ingenia, Panorama; n = 109) or Canon (Titan; n = 3). All exams included a spin echo T2 weighted (T2wSE) or T2* weighted gradient echo (T2*wGE) sequence, with or without fat suppression (FS or STIR). Among the 535 used sequences, 307 were T2wSE, 11 T2*wGE FS, 176 T2wSE-FS, and 41 T2wSE-STIR. Chest images were obtained with respiratory synchronization. The Mean acquired FOV was 410 mm (median 440, range 225–500 mm).
MR images accounted for a high data acquisition variability, including different institutions with large heterogeneity in scanner vendors, protocols, and tumor location. MR exams were acquired with a 1.5 Tesla (n = 435) or 3 Tesla (n = 100) scanners, manufactured by either General Electric Healthcare (Signa Excite HDxt, Signa Explorer, Discovery, Genesis; n = 105); Siemens Medical (Aera, Skyra, Symphony, Avanto, Magneto Espree, TrioTim, Sonata, Spectra, Verio, Harmony; n = 318); Philips Healthcare (Intera, Achieva, Ingenia, Panorama; n = 109) or Canon (Titan; n = 3). All exams included a spin echo T2 weighted (T2wSE) or T2* weighted gradient echo (T2*wGE) sequence, with or without fat suppression (FS or STIR). Among the 535 used sequences, 307 were T2wSE, 11 T2*wGE FS, 176 T2wSE-FS, and 41 T2wSE-STIR. Chest images were obtained with respiratory synchronization. The Mean acquired FOV was 410 mm (median 440, range 225–500 mm).
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