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Aplio 400

Manufactured by Canon
Sourced in Japan, Germany

The Aplio 400 is a diagnostic ultrasound system designed for a variety of clinical applications. It features advanced imaging capabilities and a user-friendly interface.

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16 protocols using aplio 400

1

Comprehensive Echocardiographic Assessment of Cardiac Function

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A standard transthoracic B-mode echocardiography/Doppler examination was carried out with commercially available ultrasound systems, comprising “GE Medical Systems” (General Electric, Freiburg, Germany), “Aplio 400” (Canon Medical Systems, Tochigi, Japan), and “Vivid E9” (General Electric Vingmed Ultrasound AS, Horten, Norway), in accordance with the current guidelines of the American Society of Echocardiography/European Association of Cardiovascular Imaging [37 (link)]. The echocardiographic Doppler assessments were focused on LV systolic and diastolic functions and LV hypertrophy (LVH) [38 (link)]. Cardiac volumes, left ventricular (LV) ejection fractions (LVEF), and left atrial volume indices (LAVI) were measured using the Simpson method. The LV end-diastolic volume (LVEDV) and LV end-systolic volume (LVESV) were normalized to the body surface area (BSA) and given as the LVEDV index (LVEDVi) and LVESV index (LVESVi). LVH was determined by the conventional echo criteria (LV mass/body surface area ≥125 g/m2 in males or ≥110 g/m2 in females). The early diastolic wave velocity (E) and mitral annular early diastolic velocity, given as averaged septal and lateral e` (e`) and E/e’ ratios, were determined by a pulsed-wave Doppler and a spectral tissue Doppler obtained from the apical 4-chamber view.
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2

Diagnostic Evaluation of Duodenal Ulcer

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The US equipment used in this study included the Xario SSA-650A and Aplio400 from Canon Medical Systems Corporation (Tochigi, Japan), with convex (3.5, 6 MHz) and linear (8, 10 MHz) transducers. The liver, gallbladder, kidneys, pancreas, spleen, the gastrointestinal tract (gastroduodenal region, small intestine, colon, and rectum), and the aorta with its branches (such as the celiac and superior mesenteric arteries) were evaluated by US. CT was performed in three patients, and the FOBT was performed in all patients. DU was confirmed by upper gastroscopy in all cases. All patients underwent a proper treatment for DU, including the administration of proton pump inhibitors. H. pylori infection was confirmed in all cases. An antibiotic agent was administered to the patient with perforated DU, and an eradication therapy for H. pylori was adopted in all patients.
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3

Standardized Echocardiographic Protocol for Aortic Stenosis

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All study echocardiograms were performed by dedicated ultra-sonographers using the following equipment: Aplio 400 (Canon Medical Systems, Tochigi, Japan), EPIQ7G (Philips Healthcare, Amsterdam, Netherland), and iE33 (Philips Healthcare, Amsterdam, Netherland). A standardized protocol, in accordance with international guidelines [20 (link), 21 (link)], was used for the echocardiographic examinations. The left ventricular mass index was measured and indexed to the body surface area using the equation provided by Devereux et al. [22 (link)]. The antegrade systolic velocity across the aortic valve was measured using continuous-wave Doppler ultrasound [20 (link)]. The aortic valve area was assessed on two-dimensional echocardiograms using the continuity equation. The mean pressure gradient was calculated using pulse and continuous-wave Doppler assessment of the aortic valve. AS severity was categorized based on standard definitions for peak velocity (mild: 2.0–2.9 m/s, moderate: 3.0–3.9 m/s, severe: ≥4.0 m/s) or mean gradient (mild: <20 mm Hg, moderate: 20–39 mm Hg, severe: ≥40 mm Hg) [23 (link)].
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4

Carotid Intima-Media Thickness Measurement

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The carotid intima-media thickness was measured using a high-resolution Doppler ultrasound Canon Aplio 400 (TUS-A400 model) with a linear 8–10 MHz transducer. The scans involved capturing B-mode images of the left and right common carotid arteries, the carotid bulb, external carotid artery and internal carotid artery. The average cIMT of the right and left common carotid arteries was assessed at least at 1 cm proximally from the origin of the bulb. An atherosclerotic plaque was identified as a localized thickening of the vessel wall that was at least 50% greater than the surrounding region or as a distinct intimal thickening protruding into the lumen, measuring more than 1.5 mm. All studies were conducted by a single vascular ultrasonographist who was blinded for the clinical data.
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5

Standard Echocardiographic Examination Protocol

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All patients underwent a resting standard echocardiographic examination using commercially available echocardiography systems (Aplio Artida, Aplio 400 and Xario; Canon Medical Systems, Tochigi, Japan, Vivid E9; GE-Vingmed, Horten, Norway, and iE33 and EPIQ7; Philips Medical Systems, Andover, MA). Digital routine grayscale two-dimensional cine loops from three consecutive heart beats were obtained at end-expiratory apnea from standard parasternal and apical views. Sector width was optimized to allow for complete myocardial visualization while maximizing the frame rate. Standard echocardiographic measurements were obtained in accordance with the current guidelines of the American Society of Echocardiography/European Association of Cardiovascular Imaging [15 (link)].
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6

Echocardiographic Assessment of Cardiac Function

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All patients underwent a resting standard echocardiographic examination using commercially available echocardiography systems (Aplio Artida, Aplio 400 and Xario; Canon Medical Systems, Otawara, Japan; Vivid E9; GE-Vingmed, Horten, Norway; and iE33 and EPIQ7; Philips Medical Systems, Andover, USA). Digital routine grayscale two-dimensional cine loops from three consecutive heart beats were obtained at end-expiratory apnea from standard parasternal and apical views. Sector width was optimized to allow for complete myocardial visualization while maximizing the frame rate. Standard echocardiographic measurements were obtained in accordance with the current guidelines of the American Society of Echocardiography/European Association of Cardiovascular Imaging (11 (link)). Specifically, the early diastolic (E) and atrial wave (A) velocities and the E-wave deceleration time were measured by pulsed-wave Doppler recording from the apical four-chamber view. The spectral pulsed-wave Doppler-derived early diastolic velocity (e′) was obtained by averaging the septal and lateral mitral annulus, and the E/e′ ratio was calculated to obtain an estimate of the LV filling pressure.
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7

Transcranial Ultrasound in Newborns

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All participants underwent standard transcranial ultrasound using a Toshiba Aplio 400 scanner (Canon Medical Systems Corporation) during the first weeks of life in an awake state. A small curved array transducer (11 MHz) was placed on the patent anterior fontanel to acquire coronal and sagittal standard views according to the Austrian and German Society for Ultrasound in Medicine [19 ]. In addition, a mid-sagittal colour Doppler image and resistive indices were obtained from the internal carotid artery and the anterior cerebral artery. Images were stored and read using a radiologic picture archiving and communication system (PACS, AGFA HealthCare). Routine radiology reports were generated for all participants.
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8

Contrast-Enhanced Ultrasonography of Canine Adrenal Masses

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All dogs underwent CEUS as follows: a suspension of perflubutane (sonazoid, Daiichi-Sankyo Corp., Tokyo, Japan) was prepared with 2 ml of
saline at an 8-µl/ml concentration. An ultrasound machine (Aplio400, Canon Medical Systems Corp., Tochigi, Japan) was used
with a 6-MHz convex probe for CEUS on the day before the operation or on the day of the operation. In all dogs, a 22- or 24-gauge intravenous catheter was
inserted in the cephalic vein depending on the animal’s size. sonazoid was injected intravenously at a volume of 0.015 ml/kg (0.12
µl/kg perflubutane), followed by a 5-ml saline injection. A sagittal view of the adrenal mass under contrast harmonic
imaging (CHI) mode was recorded for 2 min after the saline flush. The ultrasonographic examination was withdrawn, followed by another recording from 4.5 to 5
min after the saline injection. Mechanical index was set under 0.2, and ultrasonography was performed by a veterinarian. The dogs were not sedated or
anesthetized.
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9

Carotid Plaque Measurement Protocol

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Plaque was measured using an ultrasonic diagnostic equipment, Aplio 400 (Canon Medical systems, Tochigi, Japan) and LOGIQ S7 Expert (GE Healthcare Japan, Tokyo) in raw study.21 (link) The carotid artery was classified into four 15 mm long length sections: the external side of the common carotid artery (CCA), the central side of the CCA, the medial side of the inner carotid artery and the common carotid bifurcation. Then, the sum of the maximum values of intima-media thickness (IMT) exceeding 1.1 mm was calculated. In the raw data,21 (link) the plaque score was recorded as ‘0’ when IMT <1.1 mm and the specific IMT value was recorded when IMT ≥1.1 mm. The plaque was defined as IMT ≥1.1 mm based on ‘Use of carotid ultrasound to identify subclinical vascular disease and evaluate cardiovascular disease risk: a consensus statement from the American Society of Echocardiography Carotid Intima-Media Thickness Task Force. Endorsed by the Society for Vascular Medicine’,22 (link) as described in the previous analysis,23 24 (link) but the subtypes of carotid plaque were not collected in the original database.
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10

Transient Elastometry and Ultrasound Analysis of Liver

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All patients underwent transient liver elastometry using the FibroScan device (Echosens, Paris, France). The choice of sensor (M or XL) was made depending on the skin–liver capsule distance [23 (link)]. Liver stiffness values were determined using the median result of at least 10 valid measurements with an interquartile range < 30%. All studies were performed by a single trained and qualified operator. All examinations were performed by a single independent trained operator. The operator was blinded to the duplex scanning results.
All patients underwent a transabdominal ultrasound examination of the liver carried out with a convex probe at a frequency of 3.5 MHz using a Canon Aplio 400 (Tokyo, Japan) digital ultrasound multifunctional diagnostic scanner. The semiquantitative determination of the severity of liver steatosis was performed using the Hamaguchi scale [24 (link)].
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