Discovery mr750 3.0 tesla

The MR images of all subjects were collected on two same‐type scanners (Discovery MR750 3.0 Tesla, General Electric, Milwaukee, WI, USA) using the same parameters at both participating medical centers. Before MRI examinations, subjects were required to rest for 30 min. All subjects were instructed to close their eyes and remain motionless during the scan. For each subject, resting‐state fMRI data were obtained using a gradient‐echo single‐shot echo‐planar imaging sequence with the following parameters: repetition time (TR) /echo time (TE) = 2000 ms/30 ms, flip angle = 90°, field‐of‐view (FOV) = 220 mm × 220 mm, matrix = 64 × 64, slice thickness = 4.0 mm, gap = 0.5 mm, slices = 32, and volumes = 180, and the total time = 360 seconds. Sagittal three‐dimensional T1‐weighted images (3D‐T1WI) were acquired by a brain volume sequence with the following parameters: TR/TE = 8.2 ms /3.2 ms, flip angle = 12°, FOV = 256 mm × 256 mm, matrix = 256 × 256, slice thickness = 1.0 mm, no gap, slices = 188, and voxel size = 1 mm × 1 mm × 1 mm, and the total time = 259 s. T2 FLAIR images were acquired with the following parameters: TR/TE = 8400 ms/155 ms, thickness = 5.0 mm, FOV = 240 mm × 240 mm; and slices = 21.

For the measurement of intrahepatic fat content, we acquired MRI of the liver and measured HFF using a modified Dixon method with previously reported methodology (IDEAL‐IQ; GE Healthcare, Waukesha, WI, USA)11, 12 at the start of canagliflozin administration, and 6 and 12 months thereafter.
IDEAL‐IQ images representing HFF were acquired during a single breath hold using a Discovery MR750w Expert 3.0 Tesla or a Discovery MR750 3.0 Tesla (GE Healthcare). Imaging parameters on the MR750w scanner were as follows: repetition time/first echo time/Δecho time: 8.3/1.0/0.9 ms; number of echoes, six; flip angle, 4°; matrix, 160 × 160; slice thickness, 6 mm; bandwidth, ±111.11 kHz; field of vision, 36–50 cm; and acquisition time, 22 s. When using the MR750 scanner, after modification was applied: repetition time/first echo time/Δecho time, 6.3/1.0/0.8 ms; flip angle, 3°; and acquisition time, 19 s, based on the manufacturer's recommendation.
Image analysis was carried out by two authors (MI, AH) blinded to the clinical records to determine quantitative estimates of HFF under the presence of a third‐party doctor who was not involved in this study. As the region of interest, the whole liver was manually demarcated on the slice where the liver area was largest, avoiding major bile ducts and vascular structures.

All images of subjects were collected on two same-type scanners (Discovery MR750 3.0 Tesla, General Electric, Milwaukee, WI, USA) using the same parameters at both medical centers. All participants completed a 6-minute resting-state scan, during which they were asked to lie quietly in the scanner with their eyes closed. For each subject, resting-state fMRI data were obtained using a gradient echo single-shot echo-planar imaging sequence with the following parameters: repetition time (TR) / echo time (TE) = 2000 ms / 30 ms, thickness = 3.0 mm, gap = 1.0 mm, field of view (FOV) = 240 mm × 240 mm, matrix = 64 × 64, slices = 38, and volumes = 180. Sagittal three-dimensional T1-weighted images (3D-T1WI) were acquired by a brain volume (BRAVO) sequence with the following parameters: TR/TE = 8.1 ms / 3.1 ms, thickness = 1.0 mm, no gap, FOV = 256 mm × 256 mm, matrix = 256 × 256, slices = 176, and voxel size = 1 mm × 1 mm × 1 mm. T2 FLAIR images were acquired with the following parameters: TR/TE = 8400 ms / 155 ms, thickness = 5.0 mm, FOV = 240 mm × 240 mm, and slices = 21.