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18f fdg

Manufactured by Philips
Sourced in United States

18F-FDG is a radioactive tracer used in medical imaging. It is a type of fluorodeoxyglucose (FDG) labeled with the radioactive isotope fluorine-18 (18F). 18F-FDG is a positron-emitting radiopharmaceutical that can be used in positron emission tomography (PET) imaging to visualize and measure metabolic activity in the body.

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2 protocols using 18f fdg

1

Standardized PET/CT Imaging Protocols

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The Philips Gemini TF PET/CT scanner (Philips Medical Systems, Best, The Netherlands) was applied to conduct the 18F-FDG PET/CT imaging. The radiolabel was 18F-FDG (Atom High-tech Isotope Pharmaceutical Co., Ltd., Guangzhou, China; radiochemical purity > 95%). Patients were fasted for more than 4 h before examination. Fasting blood glucose was measured before intravenous injection of 18F-FDG (4.07–5.18 MBq/kg). Patients were allowed to rest for 60 min in a quiet, warm, dark condition before PET/CT examination.
The CT machine was fitted with a tube voltage of 80 kV, a tube current of 150 mAs, a screw pitch of 0.8, a rotation time of 0.5 s, and a layer thickness of 2 mm. PET acquisition was performed in three-dimensional mode; the scope of acquisition was from the upper thigh to the cranial roof, and the scanning time was 70 s/bed. The EBW system (Philips, Netherlands) was used for image reading.
HRCT acquisition was conducted while the patient was holding breath, and the scope of the scan was the lung lesion only. The acquisition parameters were as follows: (1) 120 kV, (2) 250 mAs, (3) pitch 0.8, and (4) slice thickness 1.0 mm. The lung window width and window level were 1,200 (Hounsfield unit) HU and − 600 HU, and the mediastinal window width and level were 350 HU and 40 HU, respectively.
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2

18F-FDG PET/CT Imaging Protocol for Metabolic Assessment

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All patients were requested to fast for at least 6 h before tracer injection with a serum glucose level of <11.1 mmol/L. 18F-FDG (JYAMS PET Research and Development Limited, Nanjing, Jiangsu, China) was intravenously injected at a dose of 5.2 MBq (±10%) per kilogram of body weight. After sitting still for 50 to 90 min, the patients were instructed to drink 600 to 1000 mL of water to achieve gastric distension and were scanned in the supine position with breathing at rest.
The 18F-FDG PET/CT scans were performed using a 16-slice hybrid PET/CT scanner (Gemini GXL16, Philips Medical System, Cleveland, OH, USA). An unenhanced CT scan from the skull base to the upper thigh was performed for attenuation correction (CT scanning parameters: 50 mA, 120 kV, 5 mm section thickness, 5 mm increment, and a pitch of 0.813). A three-dimensional PET scan of the same region was subsequently acquired (8–9 fields of view, 70 s per field). Then, the PET images were reconstructed in a 144 × 144 matrix with a voxel size of 4 mm × 4 mm × 4 mm and a slice thickness of 4 mm by a line-of-response algorithm. CT images were reconstructed to a 512 × 512 matrix with a pixel size of 1.17 mm × 1.17 mm. The attenuation-corrected PET/CT fusion images on three orthogonal (transaxial, coronal, and sagittal) planes were reviewed.
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