Modular analyser

Manufactured by Roche

Sourced in Switzerland, Germany

The Modular Analyser is a versatile and automated laboratory instrument designed for clinical diagnostics. It is capable of performing a wide range of analytical tests efficiently and accurately. The core function of the Modular Analyser is to automate and streamline various clinical laboratory processes, enabling healthcare professionals to obtain reliable test results in a timely manner.

Automatically generated - may contain errors

Lab products found in correlation

Advia 1800 chemistry system, by Bayer (2 mentions) Bn 2 system, by Siemens (1 mentions) Merck mega analyzer, by Merck Group (1 mentions) Metra dpd eia kit, by Quidel (1 mentions) Modular system, by Roche (1 mentions) A0021, by Agilent Technologies (1 mentions) Cobas e411 analyser, by Roche (1 mentions)

Close spelling variants of this product

Modular E170 Analyser Cobas 8000 modular analyser Modular P800 automatic analyser Modular auto analyser Cobas 8000 modular analyser series Roche modular P analyser Modular P800 analyser Modular Analytics E 170 analyser CoBAS Icobas® 8000 modular analyser series Roche Modular P chemistry analyser

15 protocols using modular analyser

Measuring Urinary and Serum Free Light Chains

Cited 1 time

Check if the same lab product or an alternative is used in the 5 most similar protocols

Serum and urine were processed immediately after collection according to pre-defined standard operating procedures and stored at -80°C until analysis.
Urinary FLCs were measured by turbidimetry on a Roche Modular P analyser using the Freelite^™ immunoassay (The Binding Site Group Ltd, Birmingham, UK). To correct for variations in urine concentration, urinary FLCs were divided by urine creatinine concentration to give urinary FLC/creatinine (FLC/Cr) ratios in mg/mmol, i.e. a kappa/creatinine ratio (KCR) and a lambda/creatinine ratio (LCR). Serum creatinine measurements were performed on a Roche Modular analyser using a rate-blanked and compensated Jaffe reaction, and eGFR was calculated using the Chronic Kidney Disease Epidemiology Collaboration (CKD-EPI) equation [20 (link)]. Serum kappa (κ) and lambda (λ) FLC concentrations were measured by nephelometry on a Dade-Behring BN^™ II System (Siemens AG, Erlangen, Germany) using the Freelite^™ assay. Urine ACR was measured using a Roche Hitachi 702 analyser. Other biochemistry testing was performed by the local clinical laboratories in accordance with the current standard of care.

Fenton A., Jesky M.D., Webster R., Stringer S.J., Yadav P., Chapple I., Dasgupta I., Harding S.J., Ferro C.J, & Cockwell P. (2018). Association between urinary free light chains and progression to end stage renal disease in chronic kidney disease. PLoS ONE, 13(5), e0197043.

+ Open protocol

+ Expand

Stress, Inflammation, and Physical Measures

Check if the same lab product or an alternative is used in the 5 most similar protocols

Waist circumference and height and weight (for calculation of BMI) were measured by trained Lifelines’ personnel during a physical visit of the second assessment. In addition to the level of psychological stress as determined by the LDI, we evaluated counts of different types of leukocytes and CRP levels as measures of inflammation and therefore indirect physical components of perceived stress (Del Giudice & Gangestad, 2018 (link); Dijkstra-de Neijs et al., 2020 (link)). Blood samples were also drawn during a physical visit of the second assessment. CRP levels were processed using a nephelometric assay in a Roche Modular analyser (Roche, Basel, Switzerland).

Warreman E., Nooteboom L., Terry M., Hoek H., Leenen P., van Rossum E., Ramlal D., Vermeiren R, & Ester W. (2023). Psychological, behavioural and biological factors associated with gastrointestinal symptoms in autistic adults and adults with autistic traits. Autism, 27(7), 2173-2186.

+ Open protocol

+ Expand

Creatinine Measurement Protocol Conversion

Check if the same lab product or an alternative is used in the 5 most similar protocols

Serum creatinine was measured routinely in our central chemistry laboratory by an isotope dilution mass spectrometry (IDMS)-traceable enzymatic assay on the Roche Modular analyser (Roche, Mannheim, Germany) from 1 March 2006 onwards. Before this date, samples were measured by Jaffe alkaline picrate assay on the Merck Mega Analyzer (Merck, Darmstadt, Germany). Values obtained by the Jaffe method were converted to allow comparison with the Roche method by the formula (Y^{Roche (µmol/L)} = (X^{Jaffe (µmol/L)} – 8)/1.07) [16 ]. To make sure that this conversion would not influence our results, we separated the analyses into the group that donated before 2006 and the group that donated after 2006 and observed no discrepancies between the two groups nor compared with the total cohort (Supplementary data, Table S1). Creatinine clearance was calculated from the 24-h urine collected the day before the measurements.

van Londen M., van der Weijden J., Niznik R.S., Mullan A.F., Bakker S.J., Berger S.P., Nolte I.M., Sanders J.S., Navis G., Rule A.D, & de Borst M.H. (2022). Prediction of measured GFR after living kidney donation from pre-donation parameters. Nephrology Dialysis Transplantation, 38(1), 212-221.

+ Open protocol

+ Expand

Measuring High-Sensitivity C-Reactive Protein

Check if the same lab product or an alternative is used in the 5 most similar protocols

Fasting blood samples from consenting LiLACS NZ participants were collected at baseline by trained phlebotomists. Samples were centrifuged and stored at -80 degrees Celsius required for processing. High sensitivity C-reactive protein (hs-CRP) was measured by a laboratory that met International Accreditation New Zealand standards, using the antigenantibody method, immunoturbidimetric reading and processed on the P module of the Roche Modular analyser (Roche Diagnostics GmbH, Mannheim, Germany).

MacDonell S.O., Moyes S.A., Teh R., Dyall L., Kerse N, & Wham C. (2023). Is the Utility of the GLIM Criteria Used to Diagnose Malnutrition Suitable for Bicultural Populations? Findings from Life and Living in Advanced Age Cohort Study in New Zealand (LiLACS NZ). The journal of nutrition, health & aging, 27(1).

+ Open protocol

+ Expand

Lipidomics Quantification Validation

Check if the same lab product or an alternative is used in the 5 most similar protocols

A series of control blood plasma (sample volume: 1.25, 2.5, 5.0, 10.0, 15.0 μl) was measured to prove detection linearity of quantified lipid species for the expected total lipid concentrations of 2.0–28.3 mM. For the analyzed samples of this screen the total lipid concentration in blood plasma varied from 5.6–18.7 mM. Within the tested concentration range the adjusted R² was greater 0.98 for the quantified lipid analytes.
Total triacylglycerol and cholesterol concentrations, as specified by lipidomics, were correlated with quantities obtained by standard enzymatic methods on a MODULAR analyser (Roche, Indianapolis, IN). The specified concentrations correlated well for total triacylglycerol (relative error = -5.48 ± 8.77%, adj. R² = 0.9754, slope = 1.0151) and total cholesterol (relative error = 7.61 ± 5.44%, adj. R² = 0.9362, slope = 0.9833). The data comparison uncovered 1 experimental outlayer in 91 analyzed plasma samples. For this sample total triglyceride differed by 7.9x; total cholesterol by 1.6x.

Kopprasch S., Dheban S., Schuhmann K., Xu A., Schulte K.M., Simeonovic C.J., Schwarz P.E., Bornstein S.R., Shevchenko A, & Graessler J. (2016). Detection of Independent Associations of Plasma Lipidomic Parameters with Insulin Sensitivity Indices Using Data Mining Methodology. PLoS ONE, 11(10), e0164173.

+ Open protocol

+ Expand

Creatinine, eGFR, and CRP Measurements

Cited 1 time

Check if the same lab product or an alternative is used in the 5 most similar protocols

Serum creatinine measurements were performed on a Roche Modular Analyser using a blank rated compensated Jaffe reaction, and eGFR was estimated using the creatinine-based CKD-EPI equation^{33 (link)}. Urinary creatinine was measured using the ADVIA 1800 Chemistry System (Bayer HealthCare). Urinary ACR was measured using a Roche Hitachi 702 analyser. C-reactive protein (CRP) was measured using the Full Range C-Reactive Protein Kit on a SPA^TM automated PLUS turbidimeter (The Binding Site Group Ltd, UK). The normal range for CRP is between 0.1 and 9 mg/L, with 90 percent below 3 mg/L^{34 (link)}.

Rasmussen D.G., Fenton A., Jesky M., Ferro C., Boor P., Tepel M., Karsdal M.A., Genovese F, & Cockwell P. (2017). Urinary endotrophin predicts disease progression in patients with chronic kidney disease. Scientific Reports, 7, 17328.

+ Open protocol

+ Expand

Bone Turnover Markers Assessment

Check if the same lab product or an alternative is used in the 5 most similar protocols

Blood samples were collected from all participants for analysis. Serum bone formation marker osteocalcin (OC) (normal reference value: 26.5 (12.8–55.0 95% CI) ng/ml) and bone resorption marker C-terminal telopeptides of type 1 collagen (CTX) (normal reference value: 0.439 (0.142–1.351 95% CI) ng/ml) were measured using enzyme-linked immunosorbent assay (ELISA) (Immunodiagnostics Systems Ltd (IDS); intra-assay CV was 1.8% & 4.7%; respectively). Serum total alkaline phosphatase was quantified by Roche Modular Analyser and expressed as a bone formation marker (u/L). Urinary bone resorption markers CTX (normal reference range: 324 (121–874 95% CI) µg/mmol/Cr) and deoxypyridinoline (DPD) (7.56 (2.27)/7.94 (3.25) nmol DPD/mmol Cr) were measured using enzyme immunosorbent assay (EIA) (Urine CrossLaps EIA, IDS, intra-assay CV was 4.7% and Urine DPD EIA, Metra DPD EIA kit; Quidel, intra-assay CV was 4.3%). Urinary CTX and DPD results were both corrected for urinary concentrations of creatinine (Cr). CTX:OC ratio was calculated. A high CTX:OC ratio means higher bone resorption relative to bone formation.

Feehan O., Magee P.J., Pourshahidi L.K., Armstrong D.J., Slevin M.M., Allsopp P.J., Conway M.C., Strain J.J, & McSorley E.M. (2022). Associations of long chain polyunsaturated fatty acids with bone mineral density and bone turnover in postmenopausal women. European Journal of Nutrition, 62(1), 95-104.

+ Open protocol

+ Expand

Calculating eGFR and Assessing Albuminuria

Check if the same lab product or an alternative is used in the 5 most similar protocols

The CKD‐EPI (Chronic Kidney Disease Epidemiology Collaboration) equation incorporating creatinine was used to calculate eGFR (Levey et al., 2009). Serum creatinine was measured using a Roche Modular Analyser using a blank rated compensated Jaffe reaction. Albuminuria was assessed using urine ACR, which was measured using the ADVIA 1800 Chemistry System (Bayer HealthCare).

Sharma P., Fenton A., Dias I.H., Heaton B., Brown C.L., Sidhu A., Rahman M., Griffiths H.R., Cockwell P., Ferro C.J., Chapple I.L, & Dietrich T. (2021). Oxidative stress links periodontal inflammation and renal function. Journal of Clinical Periodontology, 48(3), 357-367.

+ Open protocol

+ Expand

Serum and Bile Acid Biochemical Analysis

Check if the same lab product or an alternative is used in the 5 most similar protocols

Serum biochemical markers [alkaline phosphatase (ALP), alanine aminotransferase (ALT), bilirubin] were determined in an automatic analyser (Modular analyser; Roche Diagnostics GmbH, Mannheim, Germany) by using standard assays. Total serum and biliary BA levels were determined spectrophotometrically by using a Bile Acids kit (Trinity Biotech, Jamestown, NY, USA). BA levels in urine were determined by gas chromatographic/mass spectrophotometric method as previously described 34 .

Muchova L., Vanova K., Suk J., Micuda S., Dolezelova E., Fuksa L., Cerny D., Farghali H., Zelenkova M., Lenicek M., Wong R.J., Vreman H.J, & Vitek L. (2015). Protective effect of heme oxygenase induction in ethinylestradiol-induced cholestasis. Journal of Cellular and Molecular Medicine, 19(5), 924-933.

+ Open protocol

+ Expand

Renal Function and Complement Levels in Lupus Nephritis

Cited 1 time

Check if the same lab product or an alternative is used in the 5 most similar protocols

Serum creatinine was analysed according to clinical routine at the Karolinska University Hospital Clinical Chemistry Department and expressed as micromoles/liter (μmol/L). Renal function (estimated glomerular filtration rate, eGFR) was calculated using the Chronic Kidney Disease Epidemiology Collaboration equation (CKD-EPI).^{24 (link)}Complement levels were determined on a modular analyser (Roche), with normal ranges of 0.67–1.29 g/L for C3 and 0.13–0.32 g/L for C4.
In the LN group, a subset of patients was sampled before establishing this method. Such samples were analysed by nephelometry array (Beckman Coulter). The normal level using this method was 0.5–1.2 g/L for C3 and of 0.1–0.4 g/L for C4.
Anti-dsDNA antibodies were routinely analysed over the years using different methods at the Department of Clinical Immunology at the Karolinska University Hospital.
For statistical purposes, and considering the changes in laboratory methods, C3, C4 and anti-dsDNA were considered as categorical variables in this study, based on their being outside or within reference ranges.

Faustini F., Idborg H., Fuzzi E., Larsson A., Lie W.R., Pötzsch S., Okitsu S.L., Svenungsson E, & Gunnarsson I. (2022). Urine Galectin-3 binding protein reflects nephritis activity in systemic lupus erythematosus. Lupus, 32(2), 252-262.

+ Open protocol

+ Expand

About PubCompare

Our mission is to provide scientists with the largest repository of trustworthy protocols and intelligent analytical tools, thereby offering them extensive information to design robust protocols aimed at minimizing the risk of failures.

We believe that the most crucial aspect is to grant scientists access to a wide range of reliable sources and new useful tools that surpass human capabilities.

However, we trust in allowing scientists to determine how to construct their own protocols based on this information, as they are the experts in their field.

Ready to get started?

Revolutionizing how scientists
search and build protocols!