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Degma

Manufactured by Merck Group
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Sourced in United States, China

DEGMA is a laboratory product manufactured by Merck Group. It is a chemical compound used as a reagent in various scientific experiments and analytical procedures. The core function of DEGMA is to serve as a versatile and reliable tool for researchers and scientists working in various fields, including chemistry, biology, and materials science.

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Lab products found in correlation

Oegma, by Merck Group (3 mentions) 2 methacryloyloxy ethyl dimethyl 3 sulfopropyl ammoniumhydroxide, by Merck Group (1 mentions) Cyanomethyl dodecyl trithiocarbonate, by Merck Group (1 mentions) Nipam, by Merck Group (1 mentions) 4 4 azobis 4 cyanovaleric acid acva, by Merck Group (1 mentions) N 3 dimethylamino propyl n ethylcarbodiimidehydrochloride edc hcl, by Thermo Fisher Scientific (1 mentions) 2 2 azobisisobutyronitrile aibn, by Merck Group (1 mentions) 1 4 dioxane, by Merck Group (1 mentions) 4 dimethylaminopyridine dmap, by Merck Group (1 mentions) Ps pellets, by Merck Group (1 mentions) Toluene, by Merck Group (1 mentions) 2 2 dimethoxy 2 phenylacetophenone, by Merck Group (1 mentions) 2 hydroxyethyl methacrylate hema, by Merck Group (1 mentions) 2 2 azobis isobutyronitrile aibn, by Sinopharm (1 mentions) Dimethylformamide dmf, by Sinopharm (1 mentions) 2 butanone, by Merck Group (1 mentions) Tin 2 2 ethylhexanoate sn oct 2, by Merck Group (1 mentions) Copper ii bromide, by Thermo Fisher Scientific (1 mentions) 2 2 methoxyethoxy ethyl methacrylate, by Merck Group (1 mentions) Oligo ethylene glycol methyl ether methacrylate, by Merck Group (1 mentions)

6 protocols using degma

1

Electrospinning of tBA-co-DEGMA Polymer Blend

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Prior to prepare electrospun tert-butyl acrylate (tBA)-co-di(ethylene glycol) dimethacrylate (DEGMA) SMP and polystyrene (PS) mixture, the PS pellets (Mw = 35 000, Sigma-Aldrich, Inc.) are dissolved in the toluene (anhydrous, 99.8%; Sigma-Aldrich, Inc.), heated to 50 °C and stirred for 2 hours until PS pellets fully dissolved, in order to prepare the polymer concentration of 25, 30, 35 and 40 wt% PS solutions. The tBA (Sigma-Aldrich, Inc.) and DEGMA (Sigma-Aldrich, Inc.) are mixed at a weight ratio of 85 : 15, followed by adding 1 wt% photoinitiator 2,2-dimethoxy-2-phenyl-acetophenone (Sigma-Aldrich, Inc.) into the solution. Both PS and tBA-co-DEGMA (tD) solutions are mixed (50 : 50 w/w%), and then stirred for another 20 min to obtain homogeneous tD/PS solutions for electrospinning. More details of the synthesis method can be found in our previous publication.44 (link) The chemical structure is shown in Fig. 1a and b.
Xi J., Shahab S, & Mirzaeifar R. (2022). Qualifying the contribution of fiber diameter on the acrylate-based electrospun shape memory polymer nano/microfiber properties. RSC Advances, 12(45), 29162-29169.
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2

Purification and Storage of Monomers

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All
chemicals and solvents are commercially
available and were used as received unless otherwise stated. Sulfobetaine
methacrylate monomer (SBM, also named [2-(methacryloyloxy)ethyl]dimethyl-(3-sulfopropyl)ammonium
hydroxide, Sigma-Aldrich) was purified by precipitation of its methanol
solution against diethyl ether twice, followed by drying under reduced
pressure at room temperature. The purified monomer was stored in a
fridge before use. Oligo(ethylene glycol) methyl ether methacrylate
(OEGMA, Sigma-Aldrich, averaged molar mass 300 Da) and di(ethylene
glycol) methyl ether methacrylate (DEGMA, Sigma-Aldrich) were purified
by passing through neutral alumina column chromatography to remove
the inhibitors and were stored in a fridge before use. Copper metal
chips were washed, successively, with dilute sulfuric acid and water
(many times) to remove oxidized copper from surface. The cleaned copper
chips were stored under nitrogen gas.
Jiang T., Aseyev V., Niskanen J., Hietala S., Zhang Q, & Tenhu H. (2020). Polyzwitterions with LCST Side Chains: Tunable Self-Assembly. Macromolecules, 53(19), 8267-8275.
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3

Synthesis of Thermoresponsive Polymer Brushes

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The solvents petroleum ether (40–60 °C), diethyl ether, dichloromethane, ethyl acetate and acetone, and the reagents cyanomethyl dodecyl trithiocarbonate, 4,4′-azobis(4-cyanovaleric acid) (ACVA) and 4-dimethylaminopyridine (DMAP) were purchased from Sigma Aldrich and used as received. N-(3-Dimethylaminopropyl)-N′-ethylcarbodiimide hydrochloride (EDC·HCl) was purchased from Alpha Aesar and used as received. 1,4-Dioxane, and the monomers DEGMA, OEGMA (Mn = 300 g mol–1), nBA and DMA were purchased from Sigma Aldrich and passed through a column of basic alumina prior to use. NIPAM was purchased from Sigma Aldrich and recrystallized from a toluene–hexane mixture prior to use. 2,2′-Azobisisobutyronitrile (AIBN) was purchased from Sigma Aldrich and recrystallized from methanol prior to use. Dialysis membrane (MWCO = 3.5–5 kDa) was purchased from Spectra/Por. The synthesis of N,N-diethylacrylamide,61
2-cyano-2-propyl dodecyl trithiocarbonate,62
4-cyano-4-(((ethylthio)carbonothioyl)thio) pentanoic acid63
have been described previously in the literature.
Blackman L.D., Gibson M.I, & O'Reilly R.K. (2016). Probing the causes of thermal hysteresis using tunable N agg micelles with linear and brush-like thermoresponsive coronas †Electronic supplementary information (ESI) available: NMR spectra of small molecules and polymers, SEC chromatograms of the polymers, DLS, SLS and turbidimetry data for the micelles, a discussion of the chain density of micelles 11–15, additional calculations regarding the core composition of polymers 1–5 and definitions and calculations related to the light scattering data. See DOI: 10.1039/c6py01191h Click here for additional data file.. Polymer Chemistry, 8(1), 233-244.
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4

Multi-layered Temperature-responsive Polymer Brushes on Titanium Implants

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The multi-layered temperature-responsive polymer brushes (MLTRPB) on titanium (Ti) implants were fabricated using poly(ethylene glycol). Methyl ether methacrylate (OEGMA, Aldrich, Mn; 300 g/mol), di(ethylene glycol) methyl ether methacrylate (DEGMA, Sigma-Aldrich, St. Louis, MO, USA, Mw; 188.22 g/mol), and 2-hydroxyethyl methacrylate (HEMA, Sigma-Aldrich, St. Louis, MO, USA) by atom transfer radical polymerization (ATRP). Levofloxacin (LVF, USP, Israel) and gentamycin (GM, 40 mg/mL, Shinpoong Pharmaceutical Co., Ltd., Seoul, Korea) were used to test the efficacy of MLTRPB. Both agents have an antibacterial effect against different types of Gram-positive and Gram-negative bacteria, especially against the S aureus strain, the most common pathogen after orthopedic implantation [21 (link),22 (link),23 (link)].
Choi S., Lee H., Hong R., Jo B, & Jo S. (2022). Application of Multi-Layered Temperature-Responsive Polymer Brushes Coating on Titanium Surface to Inhibit Biofilm Associated Infection in Orthopedic Surgery. Polymers, 15(1), 163.
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5

Synthesis and Characterization of Insulin-Loaded Polymeric Nanoparticles

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AAPBA was purchased from the Beijing Pure Chem. Co., Ltd. (Beijing, China) and DEGMA (98%) and S-1-dodecyl-S′-(α,α′,-dimethyl-α″-acetic acid) trithiocarbonate (DDATC) from Sigma-Aldrich (Shanghai, China). Dimethyl formamide (DMF) and 2,2-azo-bis-isobutyronitrile (AIBN; 97%) were procured from the Sinopharm Chemical Reagent Co., Ltd. (Shanghai, China); the latter was purified by recrystallization from a 5% w/v solution in water before use. Dimethyl sulfoxide (DMSO) was sourced from the China National Medicines Corporation Ltd. (Beijing, China). Insulin with a nominal activity of 28 IU/mg was obtained from the Xuzhou Wanbang Biochemical Co., Ltd. (Jiangsu, China). All solvents used in this work were of analytical grade and were dried by storing over activated 4 Å molecular sieves for 24 h prior to use. Water was triple distilled before use.
Wu J.Z., Williams G.R., Li H.Y., Wang D., Wu H., Li S.D, & Zhu L.M. (2017). Glucose- and temperature-sensitive nanoparticles for insulin delivery. International Journal of Nanomedicine, 12, 4037-4057.
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6

Synthesis of Functional Copolymers

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D,L-Lactide (Sigma Aldrich), (2-(2-methoxyethoxy)ethyl methacrylate) (DEGMA, average M n ca. 188, Sigma Aldrich), oligo(ethylene glycol) methyl ether methacrylate (OEGMA, average M n ca. 500, Sigma Aldrich), copper(II) bromide (Alfa Aesar, 99%), N,N,N 0 ,N 00 ,N 00pentamethyldiethylenetriamine (PMDTA) (Sigma Aldrich, 99%), tin(II)2-ethylhexanoate (Sn(Oct) 2 ) (Sigma Aldrich, 95%), 2-butanone (Sigma Aldrich, 99%) were used as received.
Foralosso R., Moir L., Mastrotto F., Sasso L., Tchoryk A., Selo A., Grabowska A., Ashford M.B., Aylott J., Gellert P.R., Spain S.G, & Alexander C. (2017). Control of aggregation temperatures in mixed and blended cytocompatible thermoresponsive block co-polymer nanoparticles. Soft matter, 13(40).
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