Visicoil

Manufactured by IBA Dosimetry

Sourced in Germany

Visicoil is a radio-opaque fiducial marker used in radiation therapy. It is designed to be implanted in the body to aid in the localization and tracking of target tissues during imaging and treatment.

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5 protocols using visicoil

Fiducial Markers for Rectal Cancer RT

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We used 4 types of fiducials, inserted in 5 patients each (Visicoil 0.5 x 5 mm and Visicoil 0.75 x 5 mm [IBA Dosimetry, GmbH, Germany], Cook 0.64 x 3.4 mm [COOK Medical, Limerick, Ireland], and Gold Anchor 0.28 x 20 mm [unfolded length][Naslund Medical AB, Sweden]). We endoscopically placed the fiducials in the tumor and mesorectum at least 1 day before the start of radiation therapy. The fiducial insertion strategy is described in Rigter et al. 24

van den Ende R.P.J., Kerkhof E.M., Rigter L.S., van Leerdam M.E., Peters F.P., van Triest B., Staring M., Marijnen C.A.M, & van der Heide U.A. (2019). Feasibility of Gold Fiducial Markers as a Surrogate for Gross Tumor Volume Position in Image-Guided Radiation Therapy of Rectal Cancer. International journal of radiation oncology, biology, physics, 105(5).

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Catheter Displacement Measurement Protocol

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During catheter insertion, gold markers (VISICOIL; Iba-Dosimetry, Schwarzenbruck, Germany) were also implanted in the apex and base of the prostate. The apex-marker was used as a representative reference point for prostate and bulbo-membranous urethral position (Fig. 1A). Obturator with 3 mm marker and 10 mm spacer was inserted into every catheter (Fig. 2). A CT scan was acquired at 1.25 mm slice thickness prior to 1^st fraction in order to measure the catheters displacement relative to apex marker. The actual displacement was calculated by multiplying the thickness of the CT slice with the difference in number of CT slices between the slice of the apex marker and the marker of obturator of each catheter (Fig. 1D).
The slice of an apex marker and an obturator maker were defined as the most cranial slices that showed the top of marker without artifact.

Kawakami S., Ishiyama H., Terazaki T., Soda I., Satoh T., Kitano M., Kurosaka S., Sekiguchi A., Komori S., Iwamura M, & Hayakawa K. (2014). Catheter displacement prior to the delivery of high-dose-rate brachytherapy in the treatment of prostate cancer patients. Journal of Contemporary Brachytherapy, 6(2), 161-166.

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Fiducial Marker Implantation for 4DCT Imaging

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Seven of the patients had two to four 0.35 mm diameter (either 10 or 20 mm length) gold fiducial markers (Visi-coil, IBA Dosimetry, Bartlett, TN) implanted in or near the tumor or involved lymph nodes. The markers were implanted prior to 4DCT imaging by a pulmonologist using either endobronchial ultrasound-guided bronchoscopy or electromagnetic navigational bronchoscopy (Covidien superDimension, Minneapolis, MN), with the patient under conscious sedation. 4DCT images were then acquired on the same day. Details about marker location, stability, and analysis of marker to target variation can be found in Roman et al.^{11 (link)}

Hugo G.D., Weiss E., Sleeman W.C., Balik S., Keall P.J., Lu J, & Williamson J.F. (2017). A longitudinal four‐dimensional computed tomography and cone beam computed tomography dataset for image‐guided radiation therapy research in lung cancer. Medical Physics, 44(2), 762-771.

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Endobronchial Fiducial Markers for Lung Cancer Radiotherapy

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In this ethics board-approved prospective study two types of fiducial markers were implanted endobronchially in 10 patients undergoing radical radiation treatment for non-small cell lung cancer. Eight patients received a single Visicoil (IBA Dosimetry GmbH, Schwarzenbruck Germany) linear fiducial 10 Â 0.75-mm marker. Two were implanted with superDimension and superLock (Covidien Inc., Minneapolis, MN) two-band 13 Â 0.9-mm markers (one receiving two markers to assess volumetric definition capabilities). The bronchoscopic implantation was performed under conscious sedation as previously described 10 using radial probe endobronchial ultrasound 11, 12 and fluoroscopic guidance to achieve tumor localization and placement within or adjacent to peripheral lung tumors.

Jackson P., Steinfort D.P., Kron T, & Siva S. (2016). Practical Assessment of Bronchoscopically Inserted Fiducial Markers for Image Guidance in Stereotactic Lung Radiotherapy. Journal of thoracic oncology : official publication of the International Association for the Study of Lung Cancer, 11(8).

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Multimodal Imaging for Pancreatic Cancer Radiotherapy

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All patients underwent CT simulation to perform dose calculations. The UMCU patients underwent CT scanning on the same day as MRI scanning. The scanning took place 1 week after endoscopic ultrasound guided placement of 4 fiducial markers in the tumor (0.35 × 10 mm Visicoil, IBA Dosimetry, Schwarzenbruck, Germany; or 0.4 × 5 mm gold fiducial marker, QLRAD i\Inc., Miami, FL). The CT protocol consists of a 4-dimensional (4D) CT and a contrast-enhanced CT scan with an arterial and a portal venous phase. Patients were scanned in the treatment position with the custom made abdominal corset.
At MCW, patients underwent 3-dimensional (3D) and 4D CT scanning with oral and intravenous contrast in the treatment position, followed by MRI scanning, either the same day or several days after the CT simulation. No water was given for the MRI scan, but patients were asked to not eat or drink for 4 hours before both the CT and MRI scans.

Heerkens H.D., Hall W.A., Li X.A., Knechtges P., Dalah E., Paulson E.S., van den Berg C.A.T., Meijer G.J., Koay E.J., Crane C.H., Aitken K., van Vulpen M, & Erickson B.A. (2017). Recommendations for MRI-based contouring of gross tumor volume and organs at risk for radiation therapy of pancreatic cancer. Practical radiation oncology, 7(2).

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