Chloroquine diphosphate cq

Manufactured by Abcam

Sourced in United States

Chloroquine diphosphate (CQ) is a synthetic compound commonly used in research applications. It is a dihydrogen phosphate salt of chloroquine, a medication historically used to prevent and treat malaria. CQ is a water-soluble powder that can be used as a reagent in various laboratory procedures.

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Lab products found in correlation

Ampk sirna, by RiboBio (1 mentions) 3 methyladenine 3 ma, by Selleck Chemicals (1 mentions) Bafilomycin a1, by Abcam (1 mentions) Baf a1, by Abcam (1 mentions) 3 methyladenine 3 ma, by Merck Group (1 mentions)

2 protocols using chloroquine diphosphate cq

Autophagy Inhibition in Cardiomyocytes

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CRA was purchased from Jianfeng Natural Product R&D Co., Ltd (Tianjin, China). The autophagy inhibitor Chloroquine diphosphate (CQ) was obtained from ABCAM, U.S.A., and was applied to cardiomyocytes at a concentration of 10 μM. The autophagy inhibitor 3-methyladenine (3-MA) was obtained from Selleck, U.S.A., and was applied to cardiomyocytes at a concentration of 10 mM. AMPK siRNA was purchased from Guangzhou RiboBio Co., LTD (Guangzhou, China).

Wang Z.P., Shen D., Che Y., Jin Y.G., Wang S.S., Wu Q.Q., Zhou H., Meng Y.Y, & Yuan Y. (2019). Corosolic acid ameliorates cardiac hypertrophy via regulating autophagy. Bioscience Reports, 39(12), BSR20191860.

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Autophagy Modulation in Mice

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Mice were injected intraperitoneally with 3-methyladenine (3-MA, 2.5 mM in 0.35 ml, 26.1 mg/kg, Sigma-Aldrich) at G3d or G18d, 600 μM chloroquine diphosphate (CQ, 11.65 mL/kg, 2.24 mg/kg, Abcam) at G18d; Bafilomycin A1 (Baf-A1, 0.1 mg/kg, i.p. Cell Signaling Technology) 1 day before surgery for assay at G4d, and additional dose (0.1 mg/kg, i.p.) once at G2w for assay at G3w. Control mice were injected with the same volume of normal saline (NS) in the same way.

Zhang M.L., Zhao G.L., Hou Y., Zhong S.M., Xu L.J., Li F., Niu W.R., Yuan F., Yang X.L., Wang Z, & Miao Y. (2020). Rac1 conditional deletion attenuates retinal ganglion cell apoptosis by accelerating autophagic flux in a mouse model of chronic ocular hypertension. Cell Death & Disease, 11(9), 734.

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