Ecat exact hr 962 camera

PET scans were acquired on a Siemens/CTI ECAT EXACT HR + 962 camera (Knoxville, TN, USA) in 3D mode. Ten-minute transmission scans for attenuation correction were obtained prior to dynamic emission scans using a rotating 137Cs point source. Each dynamic acquisition was 90 min long and consisted of 35 frames of increasing length (1 × 30″, 6 × 10″, 3 × 20″, 3 × 30″, 3 × 60″, 6 × 120″, 8 × 300″ and 3 × 600″). 30 s after the scan start, [¹¹C]MePPEP was injected as an intravenous bolus injection of ~ 370 MBq (median 364 MBq, range 316–399 MBq; Table 1). Subjects were scanned on two separate days with a median interval of 24 days (range 1 to 309; Table 1).
The head position was maintained throughout and monitored with the camera's positioning laser. If movement was noticed, subjects were repositioned and underwent a second transmission scan at the end of the dynamic scan. To compensate for head movement during dynamic scans, we used a post hoc frame-by-frame realignment method, as described later (section “PET data quantification”). Data were reconstructed using FORE (Defrise et al., 1997 (link)) and 2D FBP (ramp filter, kernel 2.0 mm FWHM). Voxel sizes of reconstructed images were 2.092 × 2.092 × 2.42 mm.

PET scans were acquired on a Siemens/CTI ECAT EXACT HR+(“962”) camera (Knoxville, TN, USA; (Spinks et al., 2000 (link))) in 3D mode. Ten-minute transmission scans for attenuation and scatter correction were obtained prior to the dynamic emission scans using a rotating ⁶⁸Ge rod source. Each dynamic acquisition was 90.5 min long and consisted of 24 frames of increasing length (1×30 s (s), 4×15 s, 4×60 s, 2×150 s, 10×300 s, 3×600 s). [¹¹C]Ro15-4513 was injected as an intravenous bolus injection of ~440 MegaBequerels (MBq; median 441 MBq, range 430–452 MBq; Table 1) at 30 s after the dynamic scan start. Participants were scanned on two separate days with a median interval of 12 days (range 7 – 59 days; Table 1).
The head position was maintained throughout and monitored with the camera’s positioning laser. To compensate for minor head movements during the dynamic scans, we used a post hoc frame-by-frame realignment method, as described later (“PET data quantification” section). Sixty-three transaxial images were acquired per frame. Data were reconstructed using Fourier rebinning (FORE; (Defrise et al., 1997 (link))) and 2D filtered backprojection (FBP: ramp filter, kernel 2.0 millimetres (mm) Full Width at Half Maximum (FWHM)). The voxel size of reconstructed images was 2.092 mm×2.092 mm×2.42 mm and the axial (on-axis) resolution 5.6 mm (Spinks et al., 2000 (link)).

PET scans were acquired at Hammersmith Imanet on a Siemens/CTI ECAT EXACT HR+ 962 camera (Knoxville, TN, USA; Adam et al., 1997 ; Brix et al., 1997 (link)) in 3D mode, as described previously (McGinnity et al., 2017 (link)). Each participant had a 10-min transmission scan for attenuation correction, followed by a 90-min dynamic emission scan consisting of 24 frames of increasing length. [¹¹C]Ro15-4513 was injected as an intravenous bolus of median 450 MBq (interquartile range 45.1 MBq) 30 s after the dynamic emission scan start. The individuals with TLE were closely observed for evidence of seizures throughout the scan (none detected). Frames were reconstructed using Fourier rebinning (FORE; Defrise et al., 1997 (link)) and 2D filtered backprojection (ramp filter, kernel 2.0 mm full-width at half-maximum) into 63 transaxial images.