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Dodecyltrichlorosilane

Manufactured by Gelest

Dodecyltrichlorosilane is a chemical compound with the formula CH3(CH2)11SiCl3. It is a clear, colorless liquid commonly used as a precursor for the synthesis of other organosilicon compounds. The primary function of dodecyltrichlorosilane is to serve as a silylating agent, which is a class of reagents used to introduce silicon-containing groups into organic molecules.

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2 protocols using dodecyltrichlorosilane

1

Fabrication of Lipid-Coated Silica Nanoparticles

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Calf whole blood in sodium citrate was purchased from Lampire Biological Laboratories. Deionized (DI) water was obtained by filtering distilled water through a Milli-Q Advantage A10 system (MilliporeSigma, Inc.) and was used without degassing. Phosphate buffer saline (PBS, 1X), cetyltrimethylammonium chloride (CTAC, 25 wt.% in water), Triton-X100, concentrated HCl, ethanol, hexanes, dicholoromethane (DCM), and chloroform were purchased from Sigma. Tetraethylorthosilicate (TEOS) was purchased from Acros Organics. Triethylamine (TEA), calcium chloride, and perfluorobutane (PFB) were purchased from Alfa Aesar. Dodecyltrichlorosilane (DDTS) was purchased from Gelest Inc. 1,2-dipalmitoyl-sn-glycero-3-phosphocholine (DPPC), 1,2-distearoyl-sn-glycero-3-phospho-ethanolamine-N-[methoxy(polyethylene glycol)-2000] (DSPE-PEG2k), and 1,2-distearoyl-sn-glycero-3-phospho-ethanolamine-N-[methoxy(polyethylene glycol)-5000] (DSPE-PEG5k) were purchased from Avanti Polar Lipids Inc.
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2

Lipid-based Nanoparticle Synthesis Protocol

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Tetraethylorthosilicate (TEOS) was purchased from Acros Organics. Dodecyltrichlorosilane was purchased from Gelest, Inc. Cetyltrimethylammonium chloride (CTAC, 25 wt.% in water) was purchased from Sigma. Water was deionized with a Milli-Q Advantage A10 system (MilliporeSigma, Inc.) and was used without degassing. Chloroform and hexanes were purchased from Merck. Concentrated hydrochloric acid was obtained from Fischer Scientific. Bovine plasma was ordered from Lampire Biological Laboratories. 1,2-dipalmitoyl-sn-glycero-3-phosphocholine (DPPC), 1,2-dibehenoyl-sn-glycero-3-phosphocholine (DBPC), 1,2-dimyristoyl-sn-glycero-3-phosphocholine (DMPC), and 1,2-dilauroyl-sn-glycero-3-phosphocholine (DLPC), were all purchased from Avanti Polar Lipids, Inc. 1,2-distearoyl-sn-glycero-3-phospho-ethanolamine-N-[methoxy(polyethylene glycol)- 2000] (DSPE-PEG2k) was also ordered from Avanti Polar Lipids, Inc.
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