The following active substances were used in the study: the progestin gestobutanoyl (GB) and its metabolite amol were synthesized at the Pirogov Russian National Research Medical University. The structural formulas of GB and amol are shown in Figure 1 . The other compounds tested on the cells, medroxyprogesterone acetate (MPA), megestrol acetate (MA), and dienogest (D), as well as the reference substances glucocorticoid hormones dexamethasone (DEX) and hydrocortisone (HC), and the non-steroidal anti-inflammatory drug diclofenac (DFC), were obtained from Sigma (St. Louis, MO, USA).
The following reagents and equipment were used: culture flasks (Eppendorf, Hamburg, Germany); 96-well plates (Corning and Costar, Cambridge, MA, USA); DMEM/F-12 cell culture media with glutamine and RPMI (Gibco, London, UK); fetal bovine serum 10% (Gibco, Auckland, New Zealand); penicillin-streptomycin, trypsin, Versen solution, saline solution, dimethyl sulfoxide (DMSO) (PanEco, Moscow, Russia); amphotericin B (Synthesis AKOMP, Moscow, Russia); 3-(4,5-dimethylthiazol-2-yl)-2,5-tetrazolium bromide (MTT) (Diam, Moscow, Russia); a Uniplan AIFR-01 plate photometer (Ryazan, Russia).
The following reagents and equipment were used: culture flasks (Eppendorf, Hamburg, Germany); 96-well plates (Corning and Costar, Cambridge, MA, USA); DMEM/F-12 cell culture media with glutamine and RPMI (Gibco, London, UK); fetal bovine serum 10% (Gibco, Auckland, New Zealand); penicillin-streptomycin, trypsin, Versen solution, saline solution, dimethyl sulfoxide (DMSO) (PanEco, Moscow, Russia); amphotericin B (Synthesis AKOMP, Moscow, Russia); 3-(4,5-dimethylthiazol-2-yl)-2,5-tetrazolium bromide (MTT) (Diam, Moscow, Russia); a Uniplan AIFR-01 plate photometer (Ryazan, Russia).