Blood samples were analyzed for SARS-CoV-2 nucleocapsid (N) protein, as a proxy for natural SARS-CoV-2 infection, as some participants could have received one or more SARS-CoV-2 vaccines prior to blood sampling, which would result in the formation of antibodies against the spike protein but not the N protein. The presence of SARS-CoV-2 N-protein antibodies was determined by electrochemiluminescence (Elecsys anti-SARS-CoV-2 assay; Roche Diagnostics, GmbH, Germany) and a COBAS analyzer system (Roche Diagnostics) according to the manufacturers’ instructions (26 ). A positive immune response was defined by a cutoff index (COI) of >1, with a specificity of 99.8%.
Cobas analyzer system
Manufactured by Roche
Sourced in Germany
The COBAS analyzer system is a comprehensive in-vitro diagnostic (IVD) platform developed by Roche for clinical laboratories. The core function of the COBAS system is to automate and streamline the analysis of various clinical samples, such as blood, urine, and bodily fluids, to aid in the detection, diagnosis, and monitoring of a wide range of medical conditions.
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Lab products found in correlation
2 protocols using cobas analyzer system
1
Detecting SARS-CoV-2 Antibodies via N-protein
2
Detecting SARS-CoV-2 Antibodies via N-protein
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Blood samples were analyzed for SARS-CoV-2 nucleocapsid (N) protein, as a proxy for natural SARS-CoV-2 infection, as some participants could have received one or more SARS-CoV-2 vaccines prior to blood sampling, which would result in the formation of antibodies against the spike protein but not the N protein. The presence of SARS-CoV-2 N-protein antibodies was determined by electrochemiluminescence (Elecsys anti-SARS-CoV-2 assay; Roche Diagnostics, GmbH, Germany) and a COBAS analyzer system (Roche Diagnostics) according to the manufacturers’ instructions (26 ). A positive immune response was defined by a cutoff index (COI) of >1, with a specificity of 99.8%.
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