The following NHEJ inhibitors were used to enhance HDR: vanillin (12 (link)) reconstituted in H2O, 300µM final concentration (Sigma cat#V1104); SCR7-X in DMSO, 1µM final (Xcess Biosciences cat#M60082). Since we purchased SCR7-X from Xcess Biosciences we refer to this compound as “SCR7-X” as recently suggested (13 (link)). Rucaparib/AG-014699/PF-01367338, in DMSO, 1µM final (Selleckchem cat#S1098); veliparib/ABT-888 in DMSO, 5µM final (Selleckchem cat#S1004); RS-1 (14 ) in DMSO, 7.5µM final (MerckMillipore cat# 553510); RS-1 in DMSO, 7.5µM final, (Sigma cat#R9782); Luminespib/AUY-922/NVP-AUY922 in DMSO, 1µM final (Selleckchem cat#S1069); L-755,507 in DMSO, 5µM final (Tocris cat#2197); vanillin derivatives (12 (link)) 6-nitroveratraldehyde in DMSO, 3µM final (Maybridge cat#11427047), 4,5-dimethoxy-3-iodobenzaldehyde in DMSO, 3µM final (Maybridge cat#11328426); 6-bromoveratraldehyde in DMSO, 3µM final (Maybridge cat#11480124).
Rucaparib ag 014699 pf 01367338
Manufactured by Selleck Chemicals
Sourced in United States
Rucaparib/AG-014699/PF-01367338 is a laboratory chemical compound used for research purposes. It is a poly(ADP-ribose) polymerase (PARP) inhibitor. The core function of this product is to inhibit PARP activity in experimental settings.
Automatically generated - may contain errors
Lab products found in correlation
Veliparib abt 888, by Selleck Chemicals (1 mentions)
L 755 507, by Bio-Techne (1 mentions)
Niraparib mk 4827, by Selleck Chemicals (1 mentions)
Nu1025, by Selleck Chemicals (1 mentions)
Pj34 hcl, by Selleck Chemicals (1 mentions)
Azd2461, by Selleck Chemicals (1 mentions)
Ag14361, by Selleck Chemicals (1 mentions)
Upf1069, by Selleck Chemicals (1 mentions)
Talazoparib bmn 673, by Selleck Chemicals (1 mentions)
G007 lk, by Selleck Chemicals (1 mentions)
A 966492, by Selleck Chemicals (1 mentions)
Nms p118, by Selleck Chemicals (1 mentions)
2 protocols using rucaparib ag 014699 pf 01367338
1
NHEJ Inhibitors to Enhance HDR
2
PARP Inhibitor Compounds Evaluation
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The PARP inhibitors used in this study were purchased from Selleckchem (Houston, TX, USA) with the following names and catalog numbers: A-966492 (catalog number S2197), AG14361 (catalog number S2178), AZD2461 (catalog number S7029), E7449 (catalog number S8419), G007-LK (catalog number S7239), Niraparib (MK-4827; catalog number S2741), NMS-P118 (catalog number S8363), NU1025 (catalog number S7730), Olaparib (AZD2281, Ku-0059436; catalog number S1060), PJ34-HCl (catalog number S7300), Rucaparib (AG-014699, PF-01367338; catalog number S1098), Talazoparib (BMN673; catalog number S7048), and UPF1069 (catalog number S8038). Stock solutions were dissolved in dimethyl sulfoxide (DMSO) according to the manufacturer’s protocol to a concentration of 10 mM and stored at −20 °C. Table 1 lists the PARP inhibitors used in this study and their proposed targets.
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