Tf 16 big bore

Scans were performed on two different PET/CT systems from Philips (Eindhoven, The Netherlands): GEMINI TF TOF 64 (TF64) and GEMINI TF 16 Big Bore (BB). The scanners fulfilled the requirements indicated in the European Association of Nuclear Medicine (EANM) imaging guidelines (http://earl.eanm.org/ (accessed on 5 February 2021)) and obtained EANM Research Ltd. (EARL) accreditation. The transverse spatial resolution at 1 cm from the central axis of the scanner is 4.8 mm for both scanners. PET data were corrected for randomness, scattering and attenuation based on the corresponding CT dataset. The reconstruction method was a LOR-based ordered-subset iterative time-of-flight algorithm using spherical coordinates (BLOB-OS-TF) with three iterations, 33 subsets and a relaxation parameter of 0.35 for smoothing. Images were normalized to decay-corrected injected activity per kg body weight standardized-uptake-value (SUV) [g/mL]. A 3D PET scan was planned 60 min after the injection of 350 MBq [¹⁸F]FDG. A 4D PET was acquired after a 3D PET approximately 90 min post injection. The scanning parameters involved in each cohort are summarized in Table 2.

The ¹⁸F-labeled amino acid was synthesized via [¹⁸F]-fluoroalkylation of tyrosine with a specific activity larger than 18.5 GBq/μmol. The FET-PET acquisition protocol for our patient cohort was defined as follows: a static 15 min scan was performed 20 min post intravenous injection of 200–300 MBq FET. Scans were performed on two different PET/CT systems from Philips (Netherlands): GEMINI TF TOF 64 (TF64) and GEMINI TF 16 Big Bore (BB). BB was employed for 14 of the 32 patients. The scanners fulfilled the requirements indicated in the European Association of Nuclear Medicine (EANM) imaging guidelines and obtained EANM Research Ltd. (EARL) accreditation. The transverse spatial resolution at 1 cm from the central axis of the scanner was 4.8 mm. PET data was corrected for random coincidences, scatter and attenuation, based on the corresponding CT dataset. The reconstruction methods was a LOR-based ordered-subset iterative time-of-flight algorithm using spherical coordinates (BLOB) with three iterations, 33 subsets and a relaxation parameter for smoothing of 0.35. PET images had a voxel size of 2 × 2 × 2 mm³ and were normalized to decay-corrected injected activity per kg body weight (standardized-uptake-value SUV [g/ml]).