Ecat exact hr system

Manufactured by Siemens

The ECAT Exact HR system is a high-resolution positron emission tomography (PET) scanner designed for research applications. It provides precise and detailed imaging of physiological processes within the human body. The system utilizes advanced detector technology to capture high-quality images for researchers to analyze.

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ECAT Exact HR+ SOMATOMA Project 10 CT Scanner /CTI PET systems ( ECAT EXACT HR 47 system ECAT EXACT HR EXACT/HR ECAT HR+

2 protocols using ecat exact hr system

MRI and PET Imaging Protocols

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T1-weighted magnetic resonance tomography images (MRI) were obtained using a 1.5T GE Signa system (Milwaukee, WI). Images were reconstructed into a 256 x 256 x 156 matrix with a resolution of 1.02 x 1.02 x 1 mm2. PET examinations were conducted using an ECAT Exact HR system (CTI/ Siemens, Knoxville, TN). To minimize head movement a plaster helmet was customized for each subject and used during both PET and MRI examinations.
[11C]raclopride and [11C]FLB 457 were prepared as described elsewhere (Langer et al., 1999; Sandell et al., 2000) .The radioligands were administered as bolus into the antecubital vein.

Freiburghaus T., Svensson J.E., Matheson G.J., Plavén‐Sigray P., Lundberg J., Farde L., & Červenka S. (2020). Low convergent validity of [₁₁C]raclopride binding in extrastriatal brain regions: a PET study of within-subject correlations with [₁₁C]FLB 457.

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Radiosynthesis and PET Imaging of 11C-PBB3 and 11C-PiB

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¹¹C-PBB3 and ¹¹C-PiB were radiosynthesised by the Department of Radiopharmaceuticals Development at NIRS, following a previously reported protocol.13 25 26 (link) Seventy-minute dynamic PET scans were performed after an intravenous injection of ¹¹C-PBB3 (injected dose: 436±55 MBq; molar activity: 82±33 GBq/µmol) or ¹¹C-PiB (injected dose: 378±38 MBq; molar activity: 85±50 GBq/µmol). ¹¹C-PBB3 was injected under dim lighting to avoid its photoracemisation.13 (link) PET images were acquired by ECAT Exact HR+ system (Siemens AG) with an axial field of view of 155×155 mm, providing 63 contiguous slices. The intrinsic spatial resolution was 4.3 mm in-plane and 4.2 mm full-width at half-maximum axially. Subjects’ heads were restrained with a band extending across the forehead and attached to the headrest. Head movements were carefully monitored with laser beams during the PET scans, and corrections of head position were made in case of movement. PET images were reconstructed by the filtered back-projection method with corrections for attenuation and scatter.

Kitamura S., Shimada H., Niwa F., Endo H., Shinotoh H., Takahata K., Kubota M., Takado Y., Hirano S., Kimura Y., Zhang M.R., Kuwabara S., Suhara T, & Higuchi M. (2018). Tau-induced focal neurotoxicity and network disruption related to apathy in Alzheimer’s disease. Journal of Neurology, Neurosurgery, and Psychiatry, 89(11), 1208-1214.

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