Doxorubicin hcl

Manufactured by Pfizer

Sourced in Egypt

Doxorubicin-HCl is a cytotoxic agent used in the laboratory setting. It is an anthracycline antibiotic that intercalates with DNA and inhibits the activity of topoisomerase II, leading to cell death. Doxorubicin-HCl is a red-orange crystalline powder that is soluble in water and alcohol.

Automatically generated - may contain errors

Lab products found in correlation

Crocin, by Merck Group (1 mentions) Dipyridamole, by Merck Group (1 mentions) Gemcitabine hydrochloride, by Merck Group (1 mentions)

2 protocols using doxorubicin hcl

Doxorubicin and Crocin Treatment in Rats

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Rats in the doxorubicin and crocin/doxorubicin groups received intraperitoneal injections of doxorubicin (3.5 mg/kg, doxorubicin-HCl, Pfizer, Egypt) twice weekly for 3 weeks [24 (link)]. Rats in the crocin control and crocin/doxorubicin groups received intraperitoneal injections of crocin (100 mg/kg, Sigma-Aldrich, Catalog #17304) daily [19 (link)] for 3 weeks.

Hussain M.A., Abogresha N.M., AbdelKader G., Hassan R., Abdelaziz E.Z, & Greish S.M. (2021). Antioxidant and Anti-Inflammatory Effects of Crocin Ameliorate Doxorubicin-Induced Nephrotoxicity in Rats. Oxidative Medicine and Cellular Longevity, 2021, 8841726.

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Combination Chemotherapy Protocol

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KPC34 was synthesized as previously published in [20 ]. Gemcitabine Hydrochloride (#G6423) and dipyridamole (#D9766) were purchased from Sigma-Aldrich (St. Louis. MO). Cytarabine was purchased from NOVAPLUS and Doxorubicin HCl was purchased from Pfizer (New York, NY). For animal studies, all chemotherapeutic agents were dissolved in saline prior to treatment.

Alexander P.M., Caudell D.L., Kucera G.L., Pladna K.M, & Pardee T.S. (2017). The novel phospholipid mimetic KPC34 is highly active against preclinical models of Philadelphia chromosome positive acute lymphoblastic leukemia. PLoS ONE, 12(6), e0179798.

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