Dinoprost tromethamine

Manufactured by Zoetis

Sourced in United States, Brazil

Dinoprost tromethamine is a synthetic prostaglandin medication manufactured by Zoetis. It is a laboratory equipment product used for research and scientific applications.

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Lab products found in correlation

Gonadorelin hydrochloride, by Zoetis (1 mentions) Estrumate, by Merck Group (1 mentions) Lutalyse, by Zoetis (1 mentions) Eazi breed cidr, by Zoetis (1 mentions) Estradiol benzoate, by Zoetis (1 mentions) Gonadiol, by Zoetis (1 mentions) Progesterone, by Zoetis (1 mentions) Pgf2α, by Zoetis (1 mentions) Factrel, by Zoetis (1 mentions)

5 protocols using dinoprost tromethamine

Ovulation Synchronization for First TAI

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Following the expected voluntary waiting period of 55 ± 5 DIM, cows were enrolled into an ovulation synchronization protocol for first TAI and following negative pregnancy diagnoses.
Cows were presynchronized beginning at 32 ± 6 DIM using 2 injections of 25 mg (i.m.) of PGF 2α (dinoprost tromethamine; Lutalyse, Zoetis, SP, Brazil) given 14 d apart. Cows were then synchronized based on the protocol described by Pereira et al. (2015) (link): 11 d following the second PGF 2α injection of the presynchronization, cows initiated the following synchronization protocol: at d -11: intravaginal progesterone implant (Eazi-Breed controlled internal drug-releasing implant containing 1.9 mg of progesterone, Zoetis) + 2.0 mg (i.m.) of estradiol benzoate (Gonadiol, Zoetis) + 100 µg (i.m.) of gonadotropin-releasing hormone (gonadorelin diacetate; Cystorelin, Merial, SP, Brazil); at d -4: 25 mg (i.m.) of PGF 2α (dinoprost tromethamine; Lutalyse, Zoetis); at d -2: removal of intravaginal progesterone insert + 1.0 mg (i.m.) of estradiol cypionate (ECP, E.C.P., Zoetis) + 25 mg (i.m.) of PGF 2α ; and at d 0: TAI performed using commercial semen from 10 randomly selected bulls.
Positive pregnancy diagnosis was made when an amniotic vesicle with viable embryo was detected via rectal palpation with ultrasonography (Honda HS 101V with a 5.0-MHz linear probe, Honda, Tokyo, Japan) 32 and 60 d after TAI.

Polsky L.B., Madureira A.M.L., Filho E.L.D., Soriano S., Sica A.F., Vasconcelos J.L.M, & Cerri R.L.A. (2017). Association between ambient temperature and humidity, vaginal temperature, and automatic activity monitoring on induced estrus in lactating cows. Journal of dairy science, 100(10).

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Estrus Synchronization in Angus Heifers

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Virgin Angus heifers across two different years (year 1, n = 38; year 2, n = 28; total n = 66) during the month of April and located at a University of Tennessee AgResearch and Education Center were grazed on mixed grass pastures and had ad libitum access to hay. Average heifer age was 1.2 ± 0.1 yr. Estrus was synchronized according to Figure 1A and defined as the time when a heifer first stood to be mounted by another. Depending on the year, prostaglandin F_2α (PGF_2α) administered was dinoprost tromethamine (25 mg i.m.; Lutalyse, Zoetis, Parsippany, NJ, USA) or cloprostenol (500 μg i.m., Estrumate, Merck, Rahway, NJ, USA). Eleven days later, gonadotropin-releasing hormone (GnRH) was administered (100 μg i.m., gonadorelin hydrochloride, Factrel, Zoetis or 100 μg i.m., gonadorelin diacetate tetrahydrate, Cystorelin, Boehringer Ingelheim, Duluth, GA, USA). A controlled internal drug release (CIDR) device was placed intravaginally (1.38 g progesterone, Eazi-Breed CIDR, Zoetis). Seven days later, the CIDR was removed, PGF_2α was administered, and an iButton that had been previously affixed to a blank CIDR (containing no progesterone) was placed intravaginally. Beginning ~24 h after PGF_2α, estrus activity was visually assessed hourly until the first heifer displayed signs of estrus at which point monitoring was continuous by a team of individuals on a rotating schedule.

Mills M.D., Pollock A.B., Batey I.E., O’Neil M.A., Schrick F.N., Payton R.R., Moorey S.E., Fioravanti P., Hipsher W., Zoca S.M, & Edwards J.L. (2024). Magnitude and persistence of higher estrus-associated temperatures in beef heifers and suckled cows. Journal of Animal Science, 102, skae079.

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Estrus Synchronization in Ewes

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On day 0, each ewe was intramuscularly injected with 50 μg (1 mL) of GnRH analog (fertiline; gonadorelin acetate, Vetquinol, Canada), followed by PGF_2α lutalyse; dinoprost tromethamine, Zoetis, USA (10 mg) injection on day 7.

Mohan K, & Kumar N. (2023). Comparative evaluation of estrus synchronization protocols on reproductive performance and estrus behavior in Barbados Black Belly sheep. Veterinary World, 16(11), 2244-2249.

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Breeding Protocols for TAI + NM Cows

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The TAI + NM cows were synchronized using a protocol based on the use of a device with 1.9 g of natural progesterone (CIDR 1900 Cattle Insert, Zoetis, Mexico) and the administration of 2 mg IM of Estradiol Benzoate (Estradiol Benzoate, Zoetis, Mexico) on the day of insertion (60-day postpartum). At CIDR withdrawal (67-day postpartum), 400 UI IM of ECG were given (Novormon 5000, Zoetis, Mexico) together with 25 mg IM dinoprost tromethamine (Lutalyse, Zoetis, Mexico). This treatment was followed by 1 mg Estradiol Benzoate at day 68 postpartum. Thus, artificial insemination with the same commercial Brahman bull was performed at 56 ± 2 h after CIDR withdrawal. Then, 20 days after timed artificial insemination the cows were relocated to a natural mating program with a different bull.
The NM cows remained with a 5-year Brahman bull with proven fertility and acceptable following the breeding soundness evaluation in a paddock from day 60 ± 5 to 120 postpartum.

Martínez J.F., Galina C.S., Ortiz P., Corro M.D., Rubio I, & Romero-Zuñiga J.J. (2021). Backfat Thickness Does Affect the Restoration of Ovarian Activity Postpartum in Different Breeding Programs in Zebu Cattle. Frontiers in Veterinary Science, 8, 794632.

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Double-Ovsynch Protocol for Estrous Synchronization

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Cows had their estrous cycles synchronized for first TAI using a Double-Ovsynch protocol starting at 53 ± 3 DIM in herd A and 51 ± 3 DIM in herd B, as described by Souza et al. (2008) and later modified by Brusveen et al. (2009) . The GnRH (100 μg/dose of gonadorelin hydrochloride, Factrel) and the PGF 2α (25 mg/dose of dinoprost tromethamine, Lutalyse) were from Zoetis (Madison, NJ). Briefly, cows received the first GnRH treatment of the Presynch portion of the Double-Ovsynch, followed by a treatment with PGF 2α 7 d later and GnRH 72 h after PGF 2α . Seven days later, cows received a GnRH (G1) treatment followed by 2 PGF 2α treatments administered 7 and 8 d later, with the last GnRH (G2) treatment administered 56 h after the first PGF 2α treatment and AI 16 to 20 h later (Figure 1). Within each herd, cows (n = 800; n = 560 herd A; n = 240 herd B) were blocked by parity (primiparous vs. multiparous) and randomly assigned to serve as untreated controls (high-P4) or to receive a half dose of PGF 2α (low-P4; 12.5 mg of dinoprost tromethamine) 2 d before G1 (Figure 1). At each location, multiple sires with high genetic merit and proven fertility were used and were equally balanced between treatments.

Carvalho P.D., Wiltbank M.C, & Fricke P.M. (2015). Manipulation of progesterone to increase ovulatory response to the first GnRH treatment of an Ovsynch protocol in lactating dairy cows receiving first timed artificial insemination. Journal of dairy science, 98(12).

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