Millennium mg

Manufactured by GE Healthcare

Sourced in United States

The Millennium MG is a gamma camera system designed for nuclear medicine imaging. It provides high-quality images of the body's physiological processes. The Millennium MG is capable of producing planar, SPECT, and cardiac imaging studies.

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Lab products found in correlation

Discovery vh, by GE Healthcare (1 mentions) Infinia hawkeye 4, by GE Healthcare (1 mentions) Discovery nm ct 670 system, by GE Healthcare (1 mentions) Discovery nm 630, by GE Healthcare (1 mentions)

Close spelling variants of this product

Millennium MG system GE Millennium MG

7 protocols using millennium mg

Cardiac SPECT Imaging Protocol for Dyssynchrony and Perfusion

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Each patient underwent a standard resting SPECT MPI. The images were acquired using mainstream dual-head SPECT systems (Discovery VH and Millennium MG, General Electric Healthcare) with low-energy-high-resolution collimators and with standard acquisition parameters (step and shoot format with 25-30 seconds per stop, 60 projections over 180° orbit, and 8-bin gating).
The SPECT images were reconstructed using standard iterative reconstruction (ordered subset expectation maximization with 3 iterations and 10 subsets) and Butterworth filtering (cutoff frequency of 0.4 cm/cycle and power of 10). The reconstructed images were reoriented into short-axis slices and then submitted to the phase analysis to measure LV dyssynchrony [18 (link)] and sites of latest mechanical activation [19 (link)] and to the Emory Cardiac Toolbox (Emory University, Atlanta, GA, USA) to measure myocardial perfusion defects [20 (link)].

Lin X., Xu H., Zhao X, & Chen J. (2014). Sites of Latest Mechanical Activation as Assessed by SPECT Myocardial Perfusion Imaging in Ischemic and Dilated Cardiomyopathy Patients with LBBB. European journal of nuclear medicine and molecular imaging, 41(6), 1232-1239.

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Bone Scan Image Collection for Cancer Metastasis

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In this study, we collected 200 bone scan images from the Department of Nuclear Medicine of China Medical University Hospital. The details of the bone scan images are provided in Table 1. Specifically, D1 is defined as 90 images from breast cancer patients with bone metastasis. D2 is defined as 10 images from breast cancer patients without bone metastasis. D3 is defined as 50 images from prostate cancer patients with bone metastasis. D4 is defined as 50 images from prostate cancer patients without bone metastasis. Figure 1 shows bone scan images of breast cancer patients. This study has been approved by the Institutional Review Board (IRB) of China Medical University and Hospital Research Ethics Committee (CMUH106-REC2-130), approved on 27 September 2017.
The WBBS process can be described as follows. Patients undergo WBBS with a gamma camera (Millennium MG, Infinia Hawkeye 4, or Discovery NM/CT 670 system; GE Healthcare, Waukesha, WI, USA). Bone scans are acquired 2–4 h after the intravenous injection of 740–925 MBq (20–25 mCi) of technetium-99m methylene diphosphonate (Tc-99m MDP) with an acquisition time of 10–15 cm/min. The collected WBBS images are saved in DICOM format. The raw images include anterior–posterior (AP) and posterior–anterior (PA) views, with a matrix size of 1024 × 256 pixels.

Chen Y.Y., Yu P.N., Lai Y.C., Hsieh T.C, & Cheng D.C. (2023). Bone Metastases Lesion Segmentation on Breast Cancer Bone Scan Images with Negative Sample Training. Diagnostics, 13(19), 3042.

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Acetazolamide-Stressed Brain SPECT Imaging

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Baseline SPECT images and acetazolamide (ACZ) stress brain-perfusion SPECT images were obtained from all patients after admission. ACZ stress brain-perfusion SPECT (ACZ-SPECT) consists of a baseline SPECT image and an image acquired after ACZ administration. Both image types can be obtained during the course of 1 day [14 (link)].
Baseline SPECT was obtained 60 minutes after intravenous injection of 555 MBq of 99mTc-hexamethylpropyleneamineoxime (HMPAO) using a dual-head detector gamma camera (Millennium MG; GE Medical System, Milwaukee, WI, USA). Fifteen minutes before the end of the baseline SPECT, 15 mg/kg of ACZ was injected intravenously, and another 1,665 MBq of 99mTc-HMPAO was injected following completion of the baseline SPECT. ACZ-SPECT was conducted 60 minutes after the second administration of 99mTc-HMPAO.
SPECT images were acquired using low-energy high-resolution parallel-hole collimator with a γ-ray energy window of 140 keV±10% in a 128×128 matrix size. Sixty-four step-and-shoot images were obtained with intervals of 2.8° for 15 seconds per step. SPECT images were reconstructed with two iterations using ordered subset expectation maximization algorithm and regularized with a Butterworth filter.

Choi J.W., Kim M.H., Park S.A., Sin D.S, & Kim M.S. (2017). Neural Correlates of Motor Recovery Measured by SPECT at Six Months After Basal Ganglia Stroke. Annals of Rehabilitation Medicine, 41(6), 905-914.

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123I-MIBG Cardiac Imaging Protocol

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A dose of 111 MBq (3 mCi) of ¹²³I-MIBG (MyoMIBG^Ⓡ-I123 Injection; FUJIFILM Toyama Chemical Co., Ltd., Chuo-ku, Tokyo) was injected intravenously. With the patient in the supine position, anterior chest planar images were obtained 15 min (early image) and 3 h (delayed image) after the injection. Until October 2018, the scans were performed using a dual-head gamma camera (Millennium MG; GE Healthcare, Milwaukee, WI, USA) equipped with a low-energy general-purpose (LEGP) collimator with a 360 mm × 510 mm field of view (256 × 256 matrix size), 9.7% energy resolution, and 3.9-mm spatial resolution full-width at half-maximum (FWHM). After October 2018, a dual-head gamma camera (Discovery NM630; GE Healthcare) equipped with a medium-energy general-purpose (MEGP) parallel-hole collimator with a 400 mm × 500 mm field of view (128 × 128 matrix size), 9.7% energy resolution, and 3.9-mm spatial resolution FWHM was used. All scans were performed for 3 min with an energy window of 159 keV ± 10%.

Adaniya S., Takahashi M., Koyama K., Ogane K, & Momose T. (2022). Influence of antidepressant use on 123I-MIBG heart and lung uptakes in the diagnosis of Lewy body disease. Annals of Nuclear Medicine, 36(5), 488-494.

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MIBI SPECT Myocardial Perfusion Imaging

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MIBI SPECT myocardial perfusion imaging was performed at rest. Six hundred megabecquerels (MBq) of MIBI (FUJIFILM RI Pharma, Tokyo, Japan) was intravenously administered at rest. Standard data acquisition was performed 30 min after MIBI administration [19 (link)], and an additional rest SPECT data acquisition was performed 180 min after MIBI administration [5 (link)].
All images were obtained using a dual-detector gamma camera (Millennium MG, General Electric, Elgems, Tirat Carmel, Israel) equipped with a parallel hole, low-energy, high-resolution collimator. Energy discrimination was provided by a 20 % window centered at 140 keV. Thirty-two images were obtained over a 180° arc. Each image was acquired over 30 s. The data were stored on a 64 × 64 matrix. A series of 6.78-mm-thick contiguous trans-axial images were reconstructed with a filtered back-projection algorithm without attenuation correction. These trans-axial images were then reoriented in the short axis, vertical long axis, and horizontal long axis of the left ventricle.

Masuda A., Yoshinaga K., Naya M., Manabe O., Yamada S., Iwano H., Okada T., Katoh C., Takeishi Y., Tsutsui H, & Tamaki N. (2016). Accelerated 99mTc-sestamibi clearance associated with mitochondrial dysfunction and regional left ventricular dysfunction in reperfused myocardium in patients with acute coronary syndrome. EJNMMI Research, 6, 41.

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Technetium-99m Sestamibi Protocol for Limb Imaging

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Technetium-99m sestamibi (Cardiolite, Bristol-Meyers-Squibb) was reconstituted according to the manufacturer's instructions, with a consistent 98% radiochemical yield. After patients had rested for at least 30 minutes, the radiotracer was injected IV as a single bolus of 6-8 MBq/kg of body weight (about half the activity normally used for a myocardial perfusion scan). Planar static images were recorded on the lower limbs (256 × 256 matrix; acquisition time, 600 s), over the abdomen, and over the chest and shoulders using a dual-head large-FOV gamma camera (Millennium MG, GE Healthcare) equipped with low-energy, highresolution, parallel-hole collimators, centering a 10% window on the 140-keV photopeak of 99m Tc.

Mariani G., Perri M., Minichilli F., Ortori S., Linari S., Giona F., Di Rocco M., Cappellini M.D., Guidoccio F, & Erba P.A. (2016). Standardization of MRI and Scintigraphic Scores for Assessing the Severity of Bone Marrow Involvement in Adult Patients With Type 1 Gaucher Disease. AJR. American journal of roentgenology, 206(6).

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Cardiac Imaging Camera Evaluation Protocol

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Cameras used in the study were manufactured by the 3 companies with the largest number of installed units in the United States and Europe (i.e., GE Healthcare, Philips, and Siemens). Typical models of both standard-field-of-view (FOV) cameras and cardiac-dedicated limited-FOV cameras were selected. All were dual-head cameras capable of 90°configuration for cardiac imaging. Specifications for the LEHR collimators for the cameras are given in Table 1.
The initial sample size calculation was based on an estimate of intracamera variability. Assuming an initially estimated SD of 0.075 for the H/M and a 95% confidence interval (CI) half-length of 0.05, 9 cameras of each model were required to be tested. An interim analysis of data from a single camera model/collimator type combination (GE Healthcare Millennium MG/LEHR) was used to validate the sample size assumptions. This combination was selected as a reference because most subject images in the ADMIRE-HF trial were acquired on the Millennium MG. The measured SD from this analysis was then used to calculate the required sample size for the remainder of the study.

Owenius R., Zanette M, & Cella P. (2017). Variability in Heart-to-Mediastinum Ratio from Planar ¹²³I-MIBG Images of a Thorax Phantom for 6 Common γ-Camera Models. Journal of nuclear medicine technology, 45(4).

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