All solutions were prepared using ultrapure water supplied by a Milli-Q system (Millipore, USA). Chemicals were reagent grade and purchased from Sigma (St. Louis, MO) except for TTX (Tocris, UK), ryanodine (Ascent Scientific, MA), Fluo-4 (Molecular Probes, NY) and E-4031 (Enzo Life Sciences, NY). Purities for all PAHs were at least 99%. Stock PAH solutions were constituted in dimethyl sulfoxide (tissue culture grade, Sigma) at 5 mM.
E 4031
Manufactured by Enzo Life Sciences
Sourced in United Kingdom, United States
E-4031 is a selective and potent hERG channel blocker used for research purposes. It is a small molecule compound that inhibits the human ether-à-go-go-related gene (hERG) potassium channel. E-4031 is commonly utilized in studies investigating cardiac function and ion channel physiology.
Automatically generated - may contain errors
Lab products found in correlation
Milli q system, by Merck Group (1 mentions)
Dimethyl sulfoxide (dmso), by Merck Group (1 mentions)
Fluo 4, by Thermo Fisher Scientific (1 mentions)
Isoproterenol, by Merck Group (1 mentions)
Moxifloxacin, by Merck Group (1 mentions)
Propranolol, by Merck Group (1 mentions)
Dl sotalol, by Merck Group (1 mentions)
Verapamil, by Merck Group (1 mentions)
Digoxin, by Merck Group (1 mentions)
Terfenadine, by Merck Group (1 mentions)
Forskolin, by Fujifilm (1 mentions)
Astemizole, by Merck Group (1 mentions)
Aspirin, by Fujifilm (1 mentions)
Flecainide, by Merck Group (1 mentions)
Quinidine, by Fujifilm (1 mentions)
Chromanol 293b, by Bio-Techne (1 mentions)
Bay k 8644, by Abcam (1 mentions)
Milrinone, by Fujifilm (1 mentions)
2 protocols using e 4031
1
Preparation of PAH Stock Solutions
2
Compound Screening in Cell Culture
Check if the same lab product or an alternative is used in the 5 most similar protocols
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The compounds assayed in this study and their concentrations are listed in Table 1. Isoproterenol, propranolol, digoxin, astemizole, moxifloxacin, dl-sotalol, flecainide, terfenadine and verapamil were purchased from Sigma-Aldrich. E-4031 was purchased from Enzo Lifesciences (Farmingdale, NY, USA). Milrinone, forskolin, quinidine and aspirin were purchased from Wako Pure Chemical Industries (Osaka, Japan). Lidocaine was purchased from Nacalai Tesque (Kyoto, Japan). Bay K 8644 was purchased from Abcam (Cambridge, MA, USA). Chromanol 293B was purchased from Tocris Bioscience (Bristol, UK). All reagents were dissolved in dimethyl sulfoxide (DMSO) (Wako Pure Chemical Industries). The final concentration of each compound in the culture medium was at most 0.5% v/v. Each concentration was tested in triplicate or quadruplicate.
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