As a wirelessly powered implantable LED device, NFC (near-field communication) LED chips (Kyoritsu Electronics Industry, Osaka, Japan; model: KP- NFLEG (λ = 530 nm), size: 7.0 × 11.0 × 0.8 mm, weight: ~ 20 mg) were encapsulated with a UV-curable resin based on urethane polymer (STAR Lab Cosmetics, Osaka, Japan).
A handmade antenna board was used for the wireless power supply. An electromagnetic induction system was used for the power supply system with a resonance frequency of 13.56 MHz and the transmission power was 3 W. The antenna board can provide power supply with a transmission distance ranging from 0 to 105 mm from the upper side of the antenna board. The size of the antenna board was 310 mm (w) × 230 mm (d) × 105 mm (h), which was sufficient for covering the size of a mouse cage.
The central wavelength of light emitted from the LED device was confirmed using a photonic multichannel spectral analyzer system (
PMA-11, Hamamatsu Photonics K.K., Hamamatsu, Japan). The light intensity of each LED device was measured using a power meter with a photo-diode sensor (PD300-UV, Ophir, Saitama, Japan) and LED devices with a power of 50–60 µW were selected and used for the mPDT experiment. Devices in which wires had been mechanically broken were used as non-emitting devices for controls.
Kirino I., Fujita K., Sakanoue K., Sugita R., Yamagishi K., Takeoka S., Fujie T., Uemoto S, & Morimoto Y. (2020). Metronomic photodynamic therapy using an implantable LED device and orally administered 5-aminolevulinic acid. Scientific Reports, 10, 22017.