1 4 7 10 tetraazacyclododecane 1 4 7 10 tetraacetic acid dota

Manufactured by Macrocyclics

Sourced in United States

1,4,7,10-Tetraazacyclododecane-1,4,7,10-tetraacetic acid (DOTA) is a macrocyclic chelating agent. It has a polydentate structure that can form stable complexes with various metal ions.

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Lab products found in correlation

Diethylenetriamine pentaacetic acid dtpa, by Thermo Fisher Scientific (1 mentions) Chelex 100, by Merck Group (1 mentions) Naoac, by Merck Group (1 mentions) Sulfo n hydroxysulfosuccinimide sulfo nhs, by Merck Group (1 mentions) Dq gelatin, by Thermo Fisher Scientific (1 mentions) 3 4 5 dimethylthiazol 2 yl 5 3 carboxymethoxyphenyl 2 4 sulfophenyl 2h tetrazolium mts, by Promega (1 mentions) Dotap, by Avanti Polar Lipids (1 mentions) Cholesterol, by Avanti Polar Lipids (1 mentions) 3h cholesteryl hexadecyl ether 3h che, by PerkinElmer (1 mentions)

Spelling variants of this product

S-2-(4-Isothiocyanatobenzyl)-1,4,7,10-tetraazacyclododecane tetraacetic acid (p-SCN-Bn-DOTA) (7 citations) 1,4,7,10-tetraazacyclododecane-1,4,7,10-tetraacetic acid mono (N-hydroxysuccinimide ester), DOTA-NHS-ester (4 citations) 2-(p-isothiocyanatobenzyl)-1,4,7,10-tetraazacyclododecane-N,N′,N″,N‴-tetraacetic acid (p-SCN-Bn-DOTA) (2 citations) 2-(4-isothiocyanatobenzyl)-1,4,7,10 tetraazacyclododecane-1,4,7,10-tetraacetic acid (DOTA-NCS) (2 citations) S-2-(4- Isothiocyanatobenzyl)-1,4,7,10-tetraazacyclododecane-tetraacetic acid (p-SCN-Bz-DOTA) (2 citations)

3 protocols using 1 4 7 10 tetraazacyclododecane 1 4 7 10 tetraacetic acid dota

Trace Metal Purification Protocol

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Optima grade HCl comes from Aristar Ultra, VWR, West Chester, PA. Natural calcium (^natCa, 99.99%) in dendritic chunks comes from Sigma-Aldrich, St. Louis MO. UTEVA (100–150 μm) resin comes from Eichrom, Lisle IL. The cyclic chelating ligand1,4,7,10-tetraazacyclodo-decane-1,4,7,10-tetraacetic acid (DOTA) was purchased from Macrocyclics, Dallas TX. The acyclic chelating ligand diethylenetriamine pentaacetic acid (DTPA) was purchased from Acros Organics, Geel, Belgium. Sodium acetate (NaOAc) was purchased from Fisher Scientific, Pittsburg PA. Both chelating ligands and NaOAc were dissolved in 18 MΩ-cm deionized (DI) water and mixed with Chelex 100 from Sigma-Aldrich for trace metal purification. Scandium foil (99.9%) was purchased from Alfa Aesar, Ward Hill MA. A 50 ppm multi-element standard for calibration and Agilent’s 4200 Microwave Plasma Atomic Emission Spectroscopy (MP-AES) system come from Agilent Technologies, Santa Clara CA.

Valdovinos H.F., Hernandez R., Barnhart T.E., Graves S., Cai W, & Nickles R.J. (2014). Separation of cyclotron-produced 44Sc from a natural calcium target using a dipentyl pentylphosphonate functionalized extraction resin. Applied radiation and isotopes : including data, instrumentation and methods for use in agriculture, industry and medicine, 95, 23-29.

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Synthesis of Cy5.5-DOTA Conjugate

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All chemicals and solvents were obtained from commercial sources and used without further purification. Sulfo-N-hydroxysulfosuccinimide (Sulfo-NHS) and ethyl-(dimethylaminopropyl) carbodiimide (EDC) were purchased from Sigma-Aldrich. 1,4,7,10-Tetraazacyclododecane-1,4,7,10-tetraacetic acid (DOTA) was obtained from Macrocyclics, Inc. Cy5.5-Mal was purchased from GE healthcare.

Deng H., Wang H., Wang M., Li Z, & Wu Z. (2015). Synthesis and Evaluation of 64Cu-DOTA-NT-Cy5.5 as a Dual-Modality PET/Fluorescence Probe to Image Neurotensin Receptor-Positive Tumor. Molecular pharmaceutics, 12(8), 3054-3061.

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Lipid-based Nanoparticle Formulation Protocol

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POPC; DSPC; DOTAP; DSTAP; cholesterol; and 1,2-distearoyl-sn-glycero-3-phosphoethanolamine-N-[amino(PEG)-2000] (DSPE-PEG2000) were purchased from Avanti Polar Lipids Inc. (Alabaster, AL, USA). ³H-cholesterylhexadecyl ether (³H-CHE) was from PerkinElmer (Skovlunde, Denmark). 3-(4,5-Dimethylthiazol-2-yl)-5-(3-carboxymethoxyphenyl)-2-(4-sulfophenyl)-2H-tetrazolium (MTS) was purchased from Promega. DQ gelatin was from Life Technologies (Taastrup, Denmark). 9-Fluorenylmethoxycarbonyl (Fmoc) amino acids and O-(7-azabenzotriazol-1-yl)-1,1,3,3-tetramethyluronium hexafluorophosphate (HATU) were purchased from GL Biochem (Shanghai, China) or Bachem AG (Bubendorf, Switzerland). TentaGel PAP₂₀₀₀ resin was purchased from Rapp Polymere GmbH (Tuebingen, Germany). DiI was purchased from Thermo Fisher Scientific. Oxaliplatin (L-OHP) was from Lianyungang Guiyuan Chempharm Co. Ltd. (Jiangsu, China). 1,4,7,10-Tetraazacyclododecane-1,4,7,10-tetraacetic acid (DOTA) was purchased from Macrocyclics (Dallas, TX, USA). All other chemicals were from Sigma-Aldrich (Brøndby, Denmark) and of analytical grade.

Ringgaard L., Melander F., Eliasen R., Henriksen J.R., Jølck R.I., Engel T.B., Bak M., Fliedner F.P., Kristensen K., Elema D.R., Kjaer A., Hansen A.E, & Andresen T.L. (2020). Tumor repolarization by an advanced liposomal drug delivery system provides a potent new approach for chemo-immunotherapy. Science Advances, 6(36), eaba5628.

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