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N acetyl l cysteine l nac

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N-acetyl-L-cysteine (L-NAC) is a chemical compound commonly used as a laboratory reagent. It is the acetylated form of the amino acid L-cysteine. L-NAC is a source of the sulfur-containing amino acid cysteine, which is a precursor to the antioxidant glutathione.

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Lab products found in correlation

L nac, by Merck Group (2 mentions) Interferon β1a, by Merck Group (1 mentions) Dimethyl sulfoxide (dmso), by Merck Group (1 mentions) N n dimethylformamide (dmf), by Merck Group (1 mentions) Dimethyl fumarate dmf, by Merck Group (1 mentions)

Spelling variants of this product

NAC (885 citations) L-cysteine (737 citations) N-acetyl-L-cysteine (687 citations) N-acetyl-L-cysteine (NAC) (401 citations) Cysteine (321 citations) N-acetyl-L-cysteine (NAC) (A9165) (12 citations) L-NAC (8 citations) LPS (L2880), tert-butyl hydroperoxide (t-BHP, 416665), diamide (D3648), N-acetyl-l-cysteine (NAC, A9165), β-nicotinamide mononucleotide (NMN, N3501), rose bengal (330000), 2,3,5-triphenyltetrazolium chloride (TTC, T8877) (2 citations) N-acetyl-L-cysteine (NAC c = 2 mM; (2 citations) N-acetyl-L-cysteine (NAC) antioxidant (2 citations)

3 protocols using n acetyl l cysteine l nac

1

Reagents and Plasmids Used in Study

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Dimethyl fumarate (DMF) and N-Acetyl-L-Cysteine (L-NAC) were purchased from Sigma-Aldrich. DMF was dissolved in DMSO (Sigma-Aldrich) and L-NAC in water. Interferon-β1A was obtained from Merck/Sigma-Aldrich. All plasmids used in the study were from the Lin laboratory and were previously described in ref. 59 (link).
Kurmasheva N., Said A., Wong B., Kinderman P., Han X., Rahimic A.H., Kress A., Carter-Timofte M.E., Holm E., van der Horst D., Kollmann C.F., Liu Z., Wang C., Hoang H.D., Kovalenko E., Chrysopoulou M., Twayana K.S., Ottosen R.N., Svenningsen E.B., Begnini F., Kiib A.E., Kromm F.E., Weiss H.J., Di Carlo D., Muscolini M., Higgins M., van der Heijden M., Bardoul A., Tong T., Ozsvar A., Hou W.H., Schack V.R., Holm C.K., Zheng Y., Ruzek M., Kalucka J., de la Vega L., Elgaher W.A., Korshoej A.R., Lin R., Hiscott J., Poulsen T.B., O’Neill L.A., Roy D.G., Rinschen M.M., van Montfoort N., Diallo J.S., Farin H.F., Alain T, & Olagnier D. (2024). Octyl itaconate enhances VSVΔ51 oncolytic virotherapy by multitarget inhibition of antiviral and inflammatory pathways. Nature Communications, 15, 4096.
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2

UVB-Induced Oxidative Stress Mitigation

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Two 8-watts UVB Lamps (SANKYO, Japan) were used in the experiments. The intensity of UVB was standardized by UV-meter (Photoelectric Instrument Factory of Beijing Normal University, China). The culture media was removed from the cells during the irradiation and fresh medium was added to the cells after UVB irradiation. 50 mJ/cm2 of UVB was used for all the experiments. HaCaT cells are harvested or tested at 6 h post UVB irradiation. For N-acetyl-L-cysteine (L-NAC) (Sigma) treatment, the HaCaT cells were pretreated with 10 mM L-NAC for 1 h before UVB irradiation. The cells were continuously incubated with L-NAC after UVB irradiation until harvesting.
Feng J., Li L., Tong L., Tang L, & Wu S. (2016). The Involvement of Splicing Factor hnRNP A1 in UVB-Induced Alternative Splicing of hdm2. Photochemistry and photobiology, 92(2), 318-324.
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Biliatresone Isolation and Treatment

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Biliatresone was isolated as described (13 , 24 (link)) from Dysphania species plants harvested in Australia in 2008 and shipped frozen to the United States. Cells were treated with vehicle (DMSO) or biliatresone at 2 μg/ml for up to 24 h and with BSO (100 μM, Sigma #19176), N-acetyl-L-cysteine (L-NAC) (5 μM, Sigma #A9165), N-acetyl-D-cysteine (D-NAC) (5 μM, Princeton BioMolecular Research #117600) and Sulforaphane (20 μM Sigma #S4441) as described in the text.
Waisbourd‐Zinman O., Koh H., Tsai S., Lavrut P., Dang C., Zhao X., Pack M., Cave J., Hawes M., Koo K.A., Porter J.R, & Wells R.G. (2016). The toxin biliatresone causes mouse extrahepatic cholangiocyte damage and fibrosis through decreased glutathione and SOX17. Hepatology (Baltimore, Md.), 64(3), 880-893.
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