Afatinib

Manufactured by Adooq

Sourced in United States

Afatinib is a laboratory reagent used for research purposes. It is a tyrosine kinase inhibitor that targets specific mutations in the epidermal growth factor receptor (EGFR) gene. Afatinib is commonly used in cancer research to investigate its potential therapeutic applications.

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2 protocols using afatinib

MUC4 Expression Vector Construction

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The pCDH-GFP-MUC4 expression vector was generated by inserting full-length MUC4 beta (NM_138297) into the pCDH-CMV-MCS-EF1α-copGFP vector. GEM, MK-2206 (AKT inhibitor), and afatinib were purchased from AdooQ BioScience (Irvine, CA, US). Caspase-Glo^® 3/7 Reagent (G8090) was purchased from Promega Corporation (Wisconsin, United States). Capivasertib (AZD5363, AKT inhibitor) was provided by AstraZeneca plc. (Cambridge, UK).

Pan Y.R., Wu C.E., Jung S.M., Huang S.C., Lin S.H., Chou W.C., Chang Y.C., Chen M.H., Hung T.H., Yu A.L., Huang W.K, & Yeh C.N. (2023). Mucin 4 Confers Gemcitabine Resistance and an Unfavorable Prognosis in Patients with Cholangiocarcinoma via AKT Activation. International Journal of Biological Sciences, 19(9), 2772-2786.

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Cell-based Assay of Multi-Targeted Kinase Inhibitors

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Regorafenib, M-2, M-5, and elacridar were purchased from Toronto Research Chemicals (North York, ON). Ko143 was from Sigma-Aldrich (St. Louis, MO). Imatinib mesylate was from Focus Biomolecules (Plymouth Meeting, PA). Afatinib, bortezomib, cabozantinib, carfilzomib, dabrafenib, dacomitinib, dasatinib, lapatinib, lenvatinib, pazopanib, ponatinib, ruxolitinib, tofacitinib, trametinib, vandetanib, and vemurafenib were from AdooQ Bioscience (Irvine, CA). Sorafenib was from LKT Laboratories Inc. (St. Paul, MN). Sunitinib was from Synkinase Pty Ltd. (San Diego, CA). Crizotinib was from LC Laboratories Inc. (Woburn, MA). Gefitinib and erlotinib were from Cayman Chemical Company (Ann Arbor, MI). Nilotinib was from ChemScene, LLC (Monmouth Junction, NJ). All other chemicals and reagents were of analytical grade and were obtained from commercial sources.

Fujita K.I., Masuo Y., Yamazaki E., Shibutani T., Kubota Y., Nakamichi N., Sasaki Y, & Kato Y. (2017). Involvement of the Transporters P-Glycoprotein and Breast Cancer Resistance Protein in Dermal Distribution of the Multikinase Inhibitor Regorafenib and Its Active Metabolites. Journal of pharmaceutical sciences, 106(9).

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