After induction of anesthesia, the mice were positioned supine on a homeothermic blanket at 37 °C. Superb Microvascular Imaging (SMI) was used for the noninvasive assessment of microvessels. SMI imaging was performed using the Aplio 500 system (Canon Medical Systems Corp., Tokyo, Japan) with a 5- to14-MHz linear transducer. Vascular images were obtained from the region of interest (ROI), and the image parameters for SMI were as follows: velocity scale < 2 cm/sec; dynamic range, 21 dB; and frame rate, 27–60 frames/sec. The plane with the most extensive vasculature was selected as the representative image for evaluation. We evaluated the vascular index (VI, %) as a quantitative parameter. The VI indicates the ratio between the pixels for the Doppler signal and those for the whole lesion. An average of three repeated measurements was documented for each mouse tumor.
Aplio 500 system
Manufactured by Canon
Sourced in Japan
The Aplio 500 system is a diagnostic imaging device designed for ultrasound examination. It provides high-quality imaging capabilities to support clinical decision-making.
Automatically generated - may contain errors
3 protocols using aplio 500 system
1
Noninvasive Microvascular Imaging of Tumors
2
Microwave Ablation for Primary Hyperparathyroidism
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An Aplio 500 system (Canon Medical Systems, Tokyo, Japan) with a 10.0-MHz linear probe was used for US guidance. Contrast-enhanced US (CEUS) with a contrast agent (SonoVue, Bracco, Milan, Italy) was used to evaluate the effect of the ablation. For diagnosis, an MIBI scan (SymbiaT2, Siemens Healthineers, Munich, Germany) was conducted prior to the ablation procedure. Laryngoscopy was performed to rule out recurrent laryngeal nerve (RLN) impairment in patients with voice changes.
Before MWA, the diagnosis of PHPT on US was based on the following criteria: 1) enlarged hypoechoic parathyroid glands with clearly defined margins; and 2) no suspicion of lymph node metastasis.
Vitamin D supplementation in patients with vitamin D deficiency could safely begin at a dose of 1000–2000 IU/day before MWA (22 (link)). Intravenous fluid resuscitation and pharmacological management (calcitonin, bisphosphonate, and furosemide) were used in patients with PHPT who presented with a hypercalcemic crisis (serum calcium > 3.75 mmol/L).
Before MWA, the diagnosis of PHPT on US was based on the following criteria: 1) enlarged hypoechoic parathyroid glands with clearly defined margins; and 2) no suspicion of lymph node metastasis.
Vitamin D supplementation in patients with vitamin D deficiency could safely begin at a dose of 1000–2000 IU/day before MWA (22 (link)). Intravenous fluid resuscitation and pharmacological management (calcitonin, bisphosphonate, and furosemide) were used in patients with PHPT who presented with a hypercalcemic crisis (serum calcium > 3.75 mmol/L).
3
Diagnosis of Atherosclerosis and Myocardial Infarction
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Atherosclerosis was defined as the presence of any plaque in the carotid or femoral arteries, which were tested using B-mode and Doppler ultrasound examination with an Aplio 500 system (Canon Medical Systems Corp., Tochigi, Japan) with a 14L5 transducer or a Logic E9 system (GE Healthcare, Chicago, IL, USA) with a 9L transducer. Electrocardiography (ECG) was performed using a MAC 5500 HD resting ECG system (GE Healthcare, Wauwatosa, USA). Transthoracic echocardiogram (TTE) evaluation was performed using either an iE33 (S5-1 probe, Philips Medical Systems, Andover, Massachusetts, USA) or a Vivid E9 (GE Vingmed, Horten, Norway, UK) scanner with a 2.5–3.5 MHz transducer. AMI was diagnosed according to the fourth universal definition of myocardial infarction and classified as ST segment elevation myocardial infarction (STEMI), non-ST segment elevation myocardial infarction (NSTEMI), and unstable angina (UA) (11 (link)). Myocardial infarction with non-obstructive coronary arteries (MINOCA) was defined as no coronary artery stenosis > 50% in any potential infarct-related artery without other clinically overt specific causes for the acute presentation (12 (link)).
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