Blood samples were collected on day 15 of cycle 1 before and at scheduled intervals after the momelotinib dose. Plasma concentrations of momelotinib and its major metabolite (M-21) were determined using validated bioanalytical assays. Pharmacokinetic (PK) parameters were estimated using standard noncompartmental methods using Phoenix WinNonlin software Version 6.4 (Certara, Princeton, NJ).
Phoenix winnonlin software version
Manufactured by Certara
Sourced in United States
Phoenix WinNonlin software is a pharmacokinetic and pharmacodynamic modeling and analysis tool. It provides capabilities for modeling, simulation, and data analysis of drug concentration and response over time.
Automatically generated - may contain errors
Lab products found in correlation
4 protocols using phoenix winnonlin software version
1
Momelotinib Pharmacokinetics in Plasma
2
Momelotinib Pharmacokinetics in Plasma
Check if the same lab product or an alternative is used in the 5 most similar protocols
+ Expand
Blood samples were collected on day 15 of cycle 1 before and at scheduled intervals after the momelotinib dose. Plasma concentrations of momelotinib and its major metabolite (M-21) were determined using validated bioanalytical assays. Pharmacokinetic (PK) parameters were estimated using standard noncompartmental methods using Phoenix WinNonlin software Version 6.4 (Certara, Princeton, NJ).
3
Metformin Pharmacokinetic Analysis Protocol
Check if the same lab product or an alternative is used in the 5 most similar protocols
+ Expand
Pharmacokinetic parameters were calculated by non-compartmental analysis using Phoenix® WinNonlin® software version 1.3 (Certara, St. Louis, MO, USA). The areas under the plasma metformin concentration-time curves from 0 to the last observed plasma concentration (AUC0-last) were calculated by the linear up, log down trapezoidal method. Renal clearance (CLR) of metformin was calculated as the total amount of metformin excreted through the urine during the 12-hour period divided by the AUC0-last and administered dose of metformin. The maximum plasma concentration of metformin (Cmax) was directly read from the concentration-time data.
4
Pharmacokinetic Analysis of Rucaparib
Check if the same lab product or an alternative is used in the 5 most similar protocols
+ Expand
Blood and plasma TRA data and the plasma concentration of rucaparib were used to determine the Cmax, tmax, AUC from time zero to time of last measurable concentration (AUC0-t), and AUC from time zero to infinity (AUC0-inf), apparent volume of distribution (Vd/F), apparent clearance (CL/F), and terminal half-life (t1/2). Phoenix WinNonlin software version 6.3 or higher (Certara, Princeton, NJ, USA) was used to run a noncompartmental method analysis on the PK data.
About PubCompare
Our mission is to provide scientists with the largest repository of trustworthy protocols and intelligent analytical tools, thereby offering them extensive information to design robust protocols aimed at minimizing the risk of failures.
We believe that the most crucial aspect is to grant scientists access to a wide range of reliable sources and new useful tools that surpass human capabilities.
However, we trust in allowing scientists to determine how to construct their own protocols based on this information, as they are the experts in their field.
Ready to get started?
Sign up for free.
Registration takes 20 seconds.
Available from any computer
No download required
Revolutionizing how scientists
search and build protocols!