Ge signa pet mr scanner

All participants underwent PET and MRI in a single session on a GE Signa PET-MR scanner (GE Healthcare), which can simultaneously acquire PET and 3T MRI data. [¹¹C]PK11195 was injected over approximately 30 seconds and list-mode PET data were acquired for 75 minutes. The median (interquartile range [IQR]) injected activity was 397 (62) MBq with corresponding injected mass values of 3.8 (3.8) μg. Injected activity per unit body weight (MBq/kg) and injected mass were not significantly different between the mitochondrial disease and control groups. Attenuation correction included the use of a multisubject atlas method^{21 (link)} and improvements to the MRI brain coil component.²² Other data corrections (dead time, randoms, normalization, scatter, sensitivity, and decay) were as implemented on the scanner. Dynamic sinograms were reconstructed into 128 × 128 × 89 arrays (2.0 × 2.0 × 2.8 mm voxel size) using time-of-flight ordered subsets expectation maximization,^{23 (link)} with 6 iterations, 16 subsets, and no smoothing. Brain T1 and T2 MRI acquired as part of the protocol were reviewed as part of routine clinical radiology reporting.