D mannitol

Meloxicam was supplied by EGIS Ltd., (Budapest, Hungary), β-D-Mannitol (M) was obtained from Hungaropharma Plc. (Budapest, Hungary), and Poloxamer 188 (Pluronic F68) was purchased from BASF (Ludwigshafen, Germany). D-Mannitol was supplied from Molar Chemicals Ltd. (Budapest, Hungary). Trehalose dihydrate was purchased from Quadrant Holdings (Cambridge, UK). Distilled and ultrapurified water was used (Milli-Q, Millipore, Merck KGaA, Darmstadt, Germany).

Liraglutide was purchased from Xi’an Health Biochem Technology Co., Ltd. (China), Poly(lactide-co-glycolide) (PLGA 50:50, Mw = 30,000–60,000 Da), PVA (MOWIOL 4–98, MW~27,000 Da) which is a soluble polymer, and D-(+)-Trehalose dihydrate (MW = 378.33 g/mol) were purchased from Sigma Aldrich (Germany). D-(−)-Mannitol was purchased from Molar Chemicals Ltd. (Hungary). Sodium acetate anhydrous was purchased from Scharlau Chemie S.A. (Spain). Ethyl acetate used for dissoloving PLGA was from REANAL Labor (Hungary). All other chemicals in the study were of analytical reagent grade.

Liraglutide was purchased from Xi’an Health Biochem Technology Co., Ltd. (Shaanxi, China), Poly(lactide-co-glycolide) (PLGA 50:50, Mw = 30,000–60,000 Da), and PVA (MOWIOL 4-98, Mw ~ 27,000 Da) were purchased from Sigma Aldrich (Munich, Germany). d-mannitol was purchased from Molar Chemicals Ltd. (Budapest, Hungary). Sodium acetate anhydrous was purchased from Scharlau Chemie S.A. (Barcelona, Spain). Ethyl acetate was from REANAL Labor (Budapest, Hungary). Pepsin from porcine gastric mucosa, powder (≥400 units/mg protein) and pancreatin from porcine pancreas (≥3× USP specifications) were purchased from Sigma Aldrich (Budapest, Hungary). All other chemicals in the study were of analytical reagent grade.