Sprague dawley male and female rats

Manufactured by Charles River Laboratories

Sourced in United States, France

Sprague-Dawley male and female rats are a commonly used rodent model in biomedical research. They are characterized by their docile temperament, rapid growth, and well-documented physiological and behavioral attributes. These rats are bred and provided by Charles River Laboratories to serve as research subjects across a variety of scientific disciplines.

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Lab products found in correlation

Carboxymethylcellulose cmc, by Merck Group (1 mentions) Dimethyl sulfoxide (dmso), by Merck Group (1 mentions) Disulfiram, by Merck Group (1 mentions) Long evans hooded rats, by Charles River Laboratories (1 mentions)

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Sprague-Dawley rats (3110 citations) Male Sprague-Dawley rats (1198 citations) Female Sprague-Dawley rats (164 citations) Sprague-Dawley male rats (104 citations) Sprague-Dawley (76 citations) Male Sprague-Dawley (10 citations) Naïve adult female and male Sprague-Dawley rats (2 citations)

5 protocols using sprague dawley male and female rats

Zolpidem Pharmacokinetics in Rats

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Zolpidem free base (≥98% purity by HPLC) was purchased from Sigma–Aldrich (St. Louis, MO, USA) through the NIH Pharmacy. Zolpidem phenyl 4-carboxylic acid (ZPCA), ZCA, and [H²]₆-zolpidem (D6-zolpidem) were purchased from Toronto Research Chemicals (Toronto, ON, Canada). Stock solutions were prepared in DMSO (Sigma–Aldrich) that was subsequently diluted in a 1% sucrose (aq) solution for oral gavage. Male and female Sprague–Dawley rats were obtained from Charles River Labs (Germantown, MD, USA). Disulfiram was purchased from Sigma–Aldrich (St. Louis, MO, USA) as European Pharmacopeia grade reference standard and was formulated for intraperitoneal injection in a 1% suspension of carboxy methylcellulose (CMC), purchased from Sigma–Aldrich (St. Louis, MO, USA), as previously described (Sharkawi, 1980 (link)).

Peer C.J., Strope J.D., Beedie S., Ley A.M., Holly A., Calis K., Farkas R., Parepally J., Men A., Fadiran E.O., Scott P., Jenkins M., Theodore W.H, & Sissung T.M. (2016). Alcohol and Aldehyde Dehydrogenases Contribute to Sex-Related Differences in Clearance of Zolpidem in Rats. Frontiers in Pharmacology, 7, 260.

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Sprague-Dawley Rats in Social Stress

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Male and female Sprague-Dawley rats (Charles River) served as social stress “intruders” or matched controls. Rats had access to water and food ad libitum and were pair-housed for 1 week upon arrival to acclimate, then housed individually for the duration of testing. Retired breeder male Long-Evans hooded rats (Charles River) that were individually housed served as residents for male intruders. Lactating female Sprague-Dawley rats that were individually housed served as residents for female intruders. The care and use of animals was approved by the IACUC of the Children's Hospital of Philadelphia.

Urban K.R, & Valentino R.J. (2016). Age- and Sex-Dependent Impact of Repeated Social Stress on Intrinsic and Synaptic Excitability of the Rat Prefrontal Cortex. Cerebral Cortex (New York, NY), 27(1), 244-253.

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Breeding and Housing Procedures for Sprague-Dawley Rats

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Adult (90–110 days of age), Sprague-Dawley male and female rats (Charles River, MA) were used for breeding. All females were primiparous and were bred once. Males were allowed to mate up to three times before being retired. Rats were housed in sets of one male and two females until females appeared to be pregnant. At that time, females were housed individually in polypropylene cages in a vivarium that was temperature- and humidity-controlled and maintained on a 12:12 light-dark cycle with lights on at 0700. Food and water were available at all times. The Institutional Animal Care and Use Committee (IACUC) approved the experimental procedures in accordance with the National Institute of Health (NIH) guidelines.

Kosten T.A, & Nielsen D.A. (2014). Litter and Sex Effects on Maternal Behavior and DNA Methylation of the Nr3c1 Exon17 Promoter Gene in Hippocampus and Cerebellum. International journal of developmental neuroscience : the official journal of the International Society for Developmental Neuroscience, 36, 5-12.

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Stress Response in Rat Behavior

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Sixty young adult Sprague-Dawley male and female rats (males=30, females=30) approximately 2 months of age were purchased from Charles River Laboratories (Wilmington, MA) and were pair housed with a same-sex cage mate at Arizona State University housing facilities. Male and female rats were housed in separate rooms and control and experimental groups were additionally separated into different chambers on a reverse light cycle (12:12; lights off at 06:00am). Rats were given one week to acclimate before any behavioral procedures were performed. Food and water were available ad libitum except during the restraint procedure when both control and stressed animals did not have access. Rats were weighed once a week throughout the experiment. Behavioral testing was conducted during the dark phase of the light cycle. All procedures were conducted according to federal guidelines outlined in the Guide for the Care and Use of Laboratory Rats (Institute of Laboratory Animal Resources on Life Science, National Research Council, 1996) and institutional guidelines set forth by the Institutional Animal Care and Use Committee at Arizona State University.

Ortiz J.B., Taylor S.B., Hoffman A.N., Campbell A.N., Lucas L.R, & Conrad C.D. (2015). Sex-specific impairment and recovery of spatial learning following the end of chronic unpredictable restraint stress: Potential relevance of limbic GAD. Behavioural brain research, 282, 176-184.

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Rodent Neuroscience Protocol: A2A Receptor Knockout

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Wild type and A_2AR^-/- [34 (link)] CD-1 male and female mice weighing 25–50 g were used at 2–3 months of age. Also, Sprague-Dawley male and female rats (Charles River Laboratories, L’Arbresle, France) weighing 200–250 g were used at 2–3 months of age. The University of Barcelona Committee on Animal Use and Care (CEEA-UB) approved the protocol (Code 10033, 04 February 2018). Animals were housed and tested in compliance with the guidelines described in the Guide for the Care and Use of Laboratory Animals [35 (link)] and following the European Union directives (2010/63/EU), FELASA and ARRIVE guidelines. All efforts were made to minimize animal suffering, and the number of animals used. Animals were housed in groups of five in standard cages with ad-libitum access to food and water and maintained under 12 h dark/light cycle (starting at 7:30 AM), 22 °C temperature, and 66% humidity (standard conditions).

Fernández-Dueñas V., Gómez-Soler M., Valle-León M., Watanabe M., Ferrer I, & Ciruela F. (2019). Revealing Adenosine A2A-Dopamine D2 Receptor Heteromers in Parkinson’s Disease Post-Mortem Brain through a New AlphaScreen-Based Assay. International Journal of Molecular Sciences, 20(14), 3600.

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