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Hexadecyl trimethyl ammonium chloride

Manufactured by Sinopharm
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Sourced in China

Hexadecyl trimethyl ammonium chloride is a cationic surfactant commonly used in laboratory settings. It functions as a wetting agent, emulsifier, and detergent. The compound has a long hydrocarbon chain and a quaternary ammonium head group, which gives it unique chemical properties.

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Lab products found in correlation

Ascorbic acid, by Sinopharm (2 mentions) Hexadecyl trimethyl ammonium bromide, by Sinopharm (2 mentions) Calcein am propidium iodide, by Keygen Biotech (2 mentions) Chloroauric acid tetrahydrate, by Sinopharm (1 mentions) Sodium dodecyl sulfate (sds), by Sinopharm (1 mentions) Hydrochloric acid (hcl), by Sinopharm (1 mentions) Agno3, by Sinopharm (1 mentions) Nabh4, by Sinopharm (1 mentions) Nahco3, by Sinopharm (1 mentions) Sodium borohydride, by Merck Group (1 mentions) 3 mercaptopropyltrimethoxysilane mps, by Thermo Fisher Scientific (1 mentions) Annexin 5 fitc apoptosis detection kit, by Meilun (1 mentions) Tetraethoxysilane teos, by Merck Group (1 mentions) Dulbecco s modified eagle s medium dmem, by Meilun (1 mentions) Fetal bovine serum (fbs), by Meilun (1 mentions) Penicillin, by Meilun (1 mentions) Streptomycin, by Meilun (1 mentions) Rpmi 1640, by Meilun (1 mentions) Cell counting kit 8 cck 8 kit, by Dojindo Laboratories (1 mentions) Cgamp, by Biolog (1 mentions)

6 protocols using hexadecyl trimethyl ammonium chloride

1

Synthesis of Gold Nanoparticles

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Chloroauric acid tetrahydrate (HAuCl4·4H2O, AR), hexadecyl trimethyl ammonium chloride (CTAC, >99%), hexadecyl trimethyl ammonium bromide (CTAB, >99%), sodium dodecyl sulfate (SDS), NaHCO3 (>99%), NaBH4 (98%), ascorbic acid (AA, AR), AgNO3 (>99%), and HCl (30%) were purchased from Sinopharm Reagents Co. (China). Titanium trichloride (TiCl3, 15–20%) was purchased from Sigma Aldrich. Ultra-pure Milli-Q water (18.2 MΩ cm) was used throughout the study.
Chen T.M., Xu G.Y., Ren H., Zhang H., Tian Z.Q, & Li J.F. (2019). Synthesis of Au@TiO2 core–shell nanoparticles with tunable structures for plasmon-enhanced photocatalysis. Nanoscale Advances, 1(11), 4522-4528.
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2

Synthesis of Metallic Nanostructures

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Potassium(II) tetrachloropalladate (K2PdCl4, 99.99%) was obtained from Beijing HWRK Chem Co., LTD. Sodium borohydride (NaBH4, 98%) was obtained from Sigma Aldrich. 13CO2 isotope was obtained from Sigma Aldrich. Copper(II) chloride dihydrate (CuCl2·2H2O) was obtained from Aladdin. Gold(III) chloride tetrahydrate (HAuCl4·4H2O, 99.95%), ascorbic acid (AA, 99.7%), hexadecyl trimethyl ammonium bromide (CTAB, 99.0%) and hexadecyl trimethyl ammonium chloride (CTAC, 98.0%) were purchased from Sinopharm Chemical Reagent Co., Ltd. The water used in all experiments was deionized. All the chemical reagents were used as received without further purification.
Hu C., Chen X., Low J., Yang Y.W., Li H., Wu D., Chen S., Jin J., Li H., Ju H., Wang C.H., Lu Z., Long R., Song L, & Xiong Y. (2023). Near-infrared-featured broadband CO2 reduction with water to hydrocarbons by surface plasmon. Nature Communications, 14, 221.
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3

Silane-based Surface Functionalization

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3-Mercaptopropyltrimethoxysilane (MPS) was purchased from Alfa-Aesar (USA, AR, 95.0%). Tetraethyl orthosilicate (TEOS) was commercially obtained from Tianjin Fuchen Chemicals (Tianjin, China, AR, 98.0%). Hexadecyltrimethylammonium chloride (CTAC) was purchased from Sinopharm Chemicals (Beijing, China, AR, 99.0%).
Gao M., Liu Q., Xue Y., Li B., Liu X., Shi Z., Liu N, & Zou X. (2022). Facile synthesis of peanut-like Sn-doped silica nano-adsorbent for affinity separation of proteins. RSC Advances, 12(8), 4697-4702.
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4

Fabrication and Evaluation of CTAC-based Nanoparticles

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Hexadecyl trimethyl ammonium chloride (CTAC, >99%) was obtained from Sinopharm Group Chemical Reagent Co., LTD (Shenyang, China). Triethanolamine (TEA, >95%) was purchased from Tianjin Bodi Chemical Co., Ltd (Tianjin, China). Tetraethoxysilane (TEOS, 98%) was purchased from Sigma-Aldrich (Shanghai, China). ICG, 1,3-diphenyl isobenzofuran (DPBF), membrane protein extraction kit, Annexin V-FITC apoptosis detection kit, 3-(4,5-dimethylthiazol-2-yl)-2,5- diphenyltetrazolium bromide (MTT), cholecystokinin octapeptide (CCK-8) assay kit, Dulbecco's Modified Eagle's Medium (DMEM), RPMI 1640, PBS (pH 7.4), fetal bovine serum (FBS), 100 U/ml penicillin and 100 mg/ml streptomycin were all purchased from Meilun Biotechnology Co., Ltd (Dalian, China). Nitric oxide (NO) assay was acquired from Solarbio Science & Technology Co., Ltd. (Beijing, China). The mouse interleukin 12 (IL-12), mouse tumor necrosis factor-alpha (TNF-α) uncoated enzyme-linked immunosorbent assay (ELISA) kits, FITC-labeled F4/80, PE-labeled CD206 and APC-labeled CD86 monoclonal antibody were purchased from Thermo Fisher Scientific.
Gu W., Guo W., Ren Z., Zhang Y., Han M., Zhao Q., Gao Y., Mao Y, & Wang S. (2024). A bioactive nanocomposite integrated specific TAMs target and synergistic TAMs repolarization for effective cancer immunotherapy. Bioactive Materials, 38, 472-485.
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5

Multimodal Nanomedicine Evaluation

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Tetraethylorthosilicate (TEOS), 3‐aminopropyltrimethoxysilane (APTES), DAPI, and 2, 7‐dichlorodihydrofluorescein diacetate (DCFH‐DA) were purchased from Sigma‐Aldrich. Hexadecyl trimethylammonium chloride (CTAC), triethanolamine (TEA), sodium borohydride (NaBH4), and chloroplatinic acid (H2PtCl6) were purchased from Sinopharm Chemical Reagent Co. Ltd. CalceinAM/ propidium iodide (PI) was purchased from KeyGen BioTech (Shanghai, China). Annexin V‐FITC/propidium iodide (PI) and Cell Counting Kit 8 (CCK8) kit were obtained from Dojindo Laboratories. αPD1 was purchased from BioLegend, Inc (USA). cGAMP and its fluorescent analogue were purchased from BIOLOG Life Science Institute (Germany).
Wang L., Zhou H., Chen Q., Lin Z., Jiang C., Chen X., Chen M., Liu L., Shao L., Liu X., Pan J., Wu J., Song J., Wu J, & Zhang D. (2023). STING Agonist‐Loaded Nanoparticles Promotes Positive Regulation of Type I Interferon‐Dependent Radioimmunotherapy in Rectal Cancer. Advanced Science, 11(7), 2307858.
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6

Multimodal Nanoplatform for Cancer Theranostics

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Silicon phthalocyanine dichloride (SiPCCl2), 3‐aminopropyltrimethoxysilane (APTES), Hoechst 33342, tetraethylorthosilicate (TEOS), and 2, 7‐dichlorodihydroflfluorescein diacetate (DCFH‐DA) were obtained from Sigma‐Aldrich. Hexadecyl trimethylammonium chloride (CTAC), triethanolamine (TEA), and FeCl3 were obtained from Sinopharm Chemical Reagent Co. Ltd. Dylight550‐NHS was purchased from Thermo Fisher Scientific (Waltham, USA). ICG‐NHS was obtained from Xi'an Rixi Biological Technology Co. Ltd (Xi'an, China). Calcein‐AM/propidium iodide (PI), and 1, 3‐diphenylisobenzofuran (DPBF) were obtained from KeyGen BioTech (Shanghai, China). Annexin V‐FITC/PI and CCK8 were obtained from Dojindo Laboratories. Annexin V‐APC/PI was obtained from Jiangsu KeyGEN BioTECH Corp., Ltd (Jiangsu, China) Neutrophil (mouse) isolation Kit was purchased from Cayman Chemical (Michigan, USA). Anti‐CD11c‐APC, anti‐CD137‐APC, anti‐CD11b‐APC, anti‐CD86‐PE‐Cy7, antiCD3‐APC, anti‐CD80‐PE, anti‐CD8‐PE, anti‐Ly‐6G/Ly‐6C‐PE, CD54, CD95, anti‐CD8 antibody, and anti‐CD69‐FITC was purchased from BioLegend, Inc (San Diego, CA, USA). ELISA kits from Neobioscience Technology (Shenzhen, China) were obtained to detect the IFN‐γ, TNF‐α, IL‐12, and IL‐2. H22 mouse liver cancer cell‐specific neoantigen (sequence: HTDAHAQAFAALFDSMH) was obtained from GenScript USA Inc.
Wang Y., Zhao Q., Zhao B., Zheng Y., Zhuang Q., Liao N., Wang P., Cai Z., Zhang D., Zeng Y, & Liu X. (2022). Remodeling Tumor‐Associated Neutrophils to Enhance Dendritic Cell‐Based HCC Neoantigen Nano‐Vaccine Efficiency. Advanced Science, 9(11), 2105631.
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