Peg 400

Manufactured by Loba Chemie

Sourced in India

PEG 400 is a polyethylene glycol with an average molecular weight of 400 g/mol. It is a clear, viscous liquid that is miscible with water and many organic solvents.

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Lab products found in correlation

10 protocols using peg 400

In Vitro Metabolism of Pinocembrin

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Pinocembrin
(≥95%), tacrine hydrochloride (≥98%), hydroxytacrine
maleate, i.e., 1-hydroxytacrine (≥98%), and
paracetamol (≥98%) were obtained from Cayman Chemical. Fluvoxamine
maleate (≥97%), phenacetin (≥98%), diazepam (∼98%),
chlorzoxazone (≥98%), nicotinamide adenine dinucleotide phosphate
(NADPH) (≥98%), and Tween 20 were procured from Sigma-Aldrich.
Caffeine was obtained from the Indian Pharmacopoeia Commission. RLM
(lot no. RT059-D) and HLM (pool of 50 donors; lot no. PL050D-A) were
procured from Gibco. MS-grade acetonitrile and formic acid as well
as HPLC-grade methanol and acetonitrile were obtained from Thermo
Fisher Scientific. Magnesium chloride and monobasic potassium phosphate
were purchased from Rankem. PEG-400 and dimethylsulfoxide (DMSO) were
procured from Loba Chemie. Ultrapure water was obtained from a water
purification system (Direct-Q 3, Merck-Millipore). Characterization
data of the test candidate (pinocembrin) are presented in Figures S1–S4.

Bhatt S., Dhiman S., Kumar V., Gour A., Manhas D., Sharma K., Ojha P.K, & Nandi U. (2022). Assessment of the CYP1A2 Inhibition-Mediated Drug Interaction Potential for Pinocembrin Using In Silico, In Vitro, and In Vivo Approaches. ACS Omega, 7(23), 20321-20331.

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Dimenhydrinate Oral Disintegrating Tablets

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Dimenhydrinate (drug) was a gift sample from S. S. Pharmachem, Mumbai, India. HPMC E5 (film forming polymer), PEG 400 (plasticizer), citric acid (saliva stimulating agent) and sodium saccharin (sweetener) were procured from Loba Chemie, Mumbai, India. Croscarmellose sodium (superdisintegrant) was obtained from Research Lab. The remaining ingredients were of analytical grade.

Jadhav Y.G., Galgatte U.C, & Chaudhari P.D. (2018). Overcoming Poor Solubility of Dimenhydrinate: Development, Optimization and Evaluation of Fast Dissolving Oral Film. Advanced Pharmaceutical Bulletin, 8(4), 721-725.

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Topical Azelaic Acid and Tea Tree Oil Formulation

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AzA was purchased from TCI Chemicals Pvt. Ltd., Chennai, India. TTO (Melaleuca alternifolia) was purchased from Allin Exporters, Noida, India. Phospholipipon 90G (PL-90G) was supplied ex gratis by Phospholipid GmbH, Germany. Dimethyl sulfoxide (DMSO), isopropyl myristate (IPM), Tween 80, Carbopol 934, PEG 400, triethanolamine (TEA), acetonitrile (ACN), sodium dihydrogen orthophosphate, and orthophosphoric acid were purchased from Loba Chemie Pvt. Ltd., Mumbai, India. Absolute ethanol was purchased from Changshu Hongsheng Fine Chemical Co. Ltd., Changshu, China. Nutrient broth, Agar, Brain heart infusion (BHI), Erythromycin, and Resazurin Dye were purchased from Himedia Labs Pvt. Ltd., Kolkata, India. In the study, the commercial formulation of azelaic acid was Aziderm 10% w/w gel (Micro labs Ltd. Bangalore, India) procured from a local drug house. Ultrapure water prepared by Micropore™ assembly installed at Shoolini University, Solan, was used throughout the study.
The present investigation was conducted as per the guidelines of CPCSEA (Committee for controlling and supervising experiments on animals). The Institutional Animal Ethical Committee duly approved the experimental protocol of Shoolini University (IAEC/SU/09/18). Male Swiss albino mice and Wistar rats used in the current study were obtained from the central animal house of Shoolini University Solan (HP).

Bisht A., Hemrajani C., Rathore C., Dhiman T., Rolta R., Upadhyay N., Nidhi P., Gupta G., Dua K., Chellappan D.K., Dev K., Sourirajan A., Chakraborty A., Aljabali A.A., Bakshi H.A., Negi P, & Tambuwala M.M. (2021). Hydrogel composite containing azelaic acid and tea tree essential oil as a therapeutic strategy for Propionibacterium and testosterone-induced acne. Drug Delivery and Translational Research, 12(10), 2501-2517.

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Solubility Enhancement of Drugs

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EA was purchased from Yucca Enterprises Pvt. Ltd, Mumbai, India. Capmul MCM C8, and captex 500 were gifted by Abitec Corp., USA. Capryol 90, labrafil M 2125 CS, labrafil M 2130 CS, labrafac CC, labrasol, lauroglycol FCC, transcutol P were kindly gifted by Gattefosse, France. Oleic acid, tween 80, tween 20, span 20, propylene glycol, PEG 400 and PEG 200 were purchased from Loba Chemie Pvt. Ltd., Mumbai. Cremophor RH 40 was a gift from BASF, Germany.

Avachat A.M, & Patel V.G. (2014). Self nanoemulsifying drug delivery system of stabilized ellagic acid–phospholipid complex with improved dissolution and permeability. Saudi Pharmaceutical Journal : SPJ, 23(3), 276-289.

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Formulation and Evaluation of Clobazam Tablet

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Clobazam was received as a gift sample from Consern Pharma Pvt. Ltd., Ludhiana, India. Sodium starch glycolate, PEG-400, and directly compressible mannitol were received from Loba chemie Pvt. Ltd., Mumbai, India. Polyvinyl alcohol was procured from Central Drug House Pvt. Ltd., New Delhi, India. All other chemicals used were of analytical reagent grade.

Bala R., Khanna S, & Pawar P. (2014). Design Optimization and In Vitro-In Vivo Evaluation of Orally Dissolving Strips of Clobazam. Journal of Drug Delivery, 2014, 392783.

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Optimizing Topical Capsaicin Formulations

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Capsaicin was provided as a gift sample by Naturite Agro Products Limited Hyderabad, India. Labrafil M1944CS, Caproyl PGMC, Labrasol was obtained from Gattefosse India Pvt. Ltd, France as a kind gift sample. Span 80, Span 20, Tween 20, isopropyl alcohol, polyethylene glycol (PEG) 200, PEG 400, PEG 600, ethyl oleate, Labrafil M1944CS, labrafac PG, castor oil, oleic acid, isopropyl myristate (IPM), cotton seed oil, soybean oil, & olive oil were procured from LobaChemie Pvt. Ltd, Mumbai, India. Cremophor EL & Cremophor RH40 was provided by BASF, Germany. All other chemicals used were of analytical grade.

Bhagwat D.A., Swami P.A., Nadaf S.J., Choudhari P.B., Kumbar V.M., More H.N., Killedar S.G, & Kawtikwar P.S. (2021). Capsaicin Loaded Solid SNEDDS for Enhanced Bioavailability and Anticancer Activity: In-Vitro, In-Silico, and In-Vivo Characterization. Journal of pharmaceutical sciences, 110(1).

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Curcumin-Loaded Transdermal Formulations

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Curcumin was acquired from Sigma-Aldrich Chemicals Pvt. Ltd. (>94% purity) (Bangalore, India). Eudrgait S100, Eudrgait RS100, Eudrgait E100, PVP K30, Carbopol 934-P, PEG 400, propylene glycol, camphor oil, dibutyl phthalate, menthol, ethanol, and acetone were purchased from Loba Chemie Pvt. Ltd. (Mumbai, India). Transcutol P was obtained from Nice Chemical Pvt. Ltd. (Kerala, India). All other chemicals and reagents used were of analytical grades.

Shetty A., Dubey A., Chrystle J., M M., John A., N A., Das P, & Hebbar S. (2024). Fabrication and in vitro characterization of curcumin film-forming topical spray: An integrated approach for enhanced patient comfort and efficacy. F1000Research, 13, 138.

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Quantitative Analysis of Drug Metabolites

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Myricetin
(≥96%), quercetin dihydrate (≥97%), phenacetin (≥98%),
amodiaquine dihydrochloride dihydrate (≥97%), N-desethylamodiaquine dihydrochloride (≥95%), and nicotinamide
adenine dinucleotide phosphate (NADPH) (≥98%) were purchased
from Sigma-Aldrich. HLM (pool of 50 donors; lot no# PL050D-A) and
rat liver microsomes (RLM, lot no# RT053-F) were obtained from Gibco.
Dimethylsulfoxide (DMSO) and PEG-400 were obtained from Loba Chemie.
Acetonitrile, methanol, formic acid, and water (HPLC-grade and MS-grade)
were procured from Thermo Fisher. The other chemicals or reagents
were of bioreagent-grade or above.

Bhatt S., Manhas D., Kumar V., Gour A., Sharma K., Dogra A., Ojha P.K, & Nandi U. (2022). Effect of Myricetin on CYP2C8 Inhibition to Assess the Likelihood of Drug Interaction Using In Silico, In Vitro, and In Vivo Approaches. ACS Omega, 7(15), 13260-13269.

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Polymer-based Nanoparticle Encapsulation

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PTX was received as a gift sample from Shreya Life Science, Aurangabad, Maharashtra, India. Eudragit E-100, dichloromethane (DCM), glycerine, ethanol, and PEG 400 were purchased from Loba Chemie Pvt. Ltd., Mumbai, India. Polyvinyl alcohol (PVA), disodium hydrogen phosphate, and potassium dihydrogen phosphate were obtained from SD Fine Chem Ltd., Mumbai, India. All other chemicals were used of analytical grades.

Pawar A., Shete N.A., Jadhav P., Deshmukh V.K., & Mehetre J.S. (2021). Enhancement of Aqueous Solubility, Dissolution Profile, and Oral Bioavailability of Pentoxifylline by Microsponges. Pharmaceutical Fronts, 03(04), e200-e207.

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Formulation and Evaluation of Glimepiride

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Glimepiride was kindly provided by Swiss Garnier Life Sciences (Mehatpur, Una, Himachal Pradesh, India) as a gift sample. Acetone, dichloromethane, polyethylene glycol (PEG400, PEG6000), Span 80, Tween 80, polyvinyl pyrolidone (PVP K30), microcrystalline cellulose and sodium dodecyl sulphate were purchased from Loba Chemie Pvt. Ltd.
(Mumbai, India). All other chemicals and reagents were of analytical grade.

Bose S., Sharma P., Mishra V., Patial S., Saraogi G.K., Tambuwala M.M., & Dua K. (2021). Comparative in vitro evaluation of glimepiride containing nanosuspension drug delivery system developed by different techniques. Journal of Molecular Structure, 1231, 129927-129927.

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