Cobas e411 autoanalyzer

Manufactured by Roche

Sourced in Germany, Switzerland

The Cobas e411 autoanalyzer is a compact, automated immunoassay analyzer designed for clinical laboratories. It is capable of performing a variety of immunoassay tests, including those for hormones, therapeutic drug monitoring, and infectious disease markers. The Cobas e411 autoanalyzer features automated sample handling, reagent management, and result calculation to provide efficient and reliable testing.

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Lab products found in correlation

Xn 1000 hematology analyzer, by Sysmex (1 mentions) Konelab 20, by Thermo Fisher Scientific (1 mentions) Dca vantage analyzer, by Siemens (1 mentions) Immulite 1000, by Siemens (1 mentions) Cobas integra 400 plus, by Roche (1 mentions) Microvue bap, by Quidel (1 mentions) Cobas c311 autoanalyzer, by Roche (1 mentions)

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Cobas e411 (523 citations) AutoAnalyzer (35 citations) Cobas autoanalyzer (9 citations)

9 protocols using cobas e411 autoanalyzer

Antibody Response After COVID-19 Vaccination

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Complete blood count: Complete blood count was analyzed using the Sysmex Hematology Analyzer XN-1000. This examination was mainly to evaluate hemoglobin, leukocytes, and platelets at week 7 after administering 2 doses of vaccine.
ECLIA: Anti-SARS-CoV-2 antibodies were examined using the ECLIA method on the Cobas e411 autoanalyzer, Roche. The sample results were stated as reactive or nonreactive in the form of a cut-off index (COI). Meanwhile, Anti-S-RBD SARS-CoV-2-S antibody examination was carried out using the ECLIA method on the Cobas e411 autoanalyzer, Roche. The test results were declared negative when < 0.80 U/mL and positive when the value was 0.80 U/mL. Data Analysis: Data were collected at 7 and 26 weeks after the participants had received the second dose of vaccine. About 34 out of 194 participants were excluded due to active infection during sample collection. Up to the 26th week of follow-up, participants who

Chilmi S., Kesuma T.A., Wibawa P.A., Susianti H., Iskandar A., Wulanda I.A., Wahono C.S, & Handono K. (2024). The Long-Term Serological Profile of CoronaVac Vaccine Based on Comorbidities and History of SARS-CoV-2 Infection in Indonesia. Japanese journal of infectious diseases, 77(1).

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Seroprevalence of SARS-CoV-2 IgG Antibodies

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The samples were collected from May 2020 to August 2020 from various municipalities of the state of Zacatecas in Mexico. Blood samples from recovered patients of mild COVID-19 treated as outpatients were collected through venipuncture in a vacuum collection tube with EDTA-K2. Collected samples were centrifuged at 1500 rpm for 5 min to obtain plasma to determine N-specific IgG by ELISA according to the manufacturer’s protocol.
The seroprevalence was estimated based on the IgG isotype, since IgM does not provide long-term memory information [20 (link)]. In this sense, the detection of IgG makes it possible to evaluate the scope of herd immunity as a monitoring and epidemiological surveillance strategy. A blood sample was used from each participant with prior informed consent to determine the presence of anti-SARS-CoV-2 IgG antibodies by means of an electrochemiluminescence immunoassay, Elecsys^® Anti-SARS-CoV-2, Precicontrol, using a COBAS e411 autoanalyzer (Roche Diagnostics). Anti-N IgG titers were considered positive with a cut-off index of >1.

Méndez-Frausto G., Godina-González S., Rivas-Santiago C.E., Nungaray-Anguiano E., Mendoza-Almanza G., Rivas-Santiago B., Galván-Tejada C.E, & Gonzalez-Curiel I.E. (2022). Downregulation of sCD40 and sCTLA4 in Recovered COVID-19 Patients with Comorbidities. Pathogens, 11(10), 1128.

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Comprehensive Cardiometabolic Assessment

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Anthropometrics were collected at recruitment (baseline), 6-month and 12-month. The anthropometrics included height (cm), weight (kg), waist and hip circumferences (cm), systolic and diastolic blood pressure by standard methods. Fasting blood samples, taken at each time point, were sent immediately to Prince Mutaib Chair for biomarkers in Osteoporosis (PMCO), King Saud University (KSU), Riyadh where they were processed, aliquoted and stored at recommended temperature for further analysis.
Fasting blood glucose and lipid profile was quantified using routine biochemical tests in an automated biochemistry analyzer (Konelab 20, Thermo-Fischer scientific, Helsinki, Finland). The reagents were supplied ready to use by Thermo Fischer (catalog# 981379 for glucose; 981812 for total cholesterol; 981823 for HDL-cholesterol and 981301 for triglyceride). The imprecision, calculated as the total CV, was ≤5%, ≤3.5%, ≤4% and ≤4% for these tests respectively. 25(OH)vitamin D was quantified using COBAS e-411 autoanalyzer (Roche Diagnostics, Indianapolis, IN, USA). Glycated haemoglobin (HbA1c) was quantified in DCA vantage analyzer (Siemens, Munich, Germany). The imprecision of the HbA1c assay was ≤3.6% in the important clinical ranges. The standards and controls used for these biochemical assays were routinely tested by Quality assurance department of KSU, for highly reproducible research data.

Alfawaz H.A., Wani K., Alnaami A.M., Al-Saleh Y., Aljohani N.J., Al-Attas O.S., Alokail M.S., Kumar S, & Al-Daghri N.M. (2018). Effects of Different Dietary and Lifestyle Modification Therapies on Metabolic Syndrome in Prediabetic Arab Patients: A 12-Month Longitudinal Study. Nutrients, 10(3), 383.

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Hormonal Biomarker Assessment in Blood

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EDTA-anticoagulated blood samples were drawn between 8:00 and 8:30 a.m. After centrifugation, plasma aliquots were preserved at −80°C. Cortisol was measured by electrochemiluminescence (Cobas e411 autoanalyzer, Roche Diagnostics GmbH, Germany), DHEA by radioimmunoassay (IMMUNOTECH S.A. Marseille Cedex 9, France) and DHEA-S by immunochemoluminiscence (IMMULITE® 1000, Siemens Healthcare Diagnostics, USA) tests. All hormone determinations were performed using the same blood samples aliquots.

Vecchione M.B., Angerami M.T., Suarez G.V., Turk G., Laufer N., Ben G., Ameri D., Gonzalez D., Parodi L.M., Giavedoni L.D., Maidana P., Fabre B., Mesch V., Sued O, & Quiroga M.F. (2021). Immune variations throughout the course of tuberculosis treatment and its relationship with adrenal hormone changes in HIV-1 patients co-infected with Mycobacterium tuberculosis. Tuberculosis (Edinburgh, Scotland), 127, 102045.

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Bone Biomarker Assessment in Serum

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Fasting blood samples were drawn between 8:00 a.m. and 11:00 a.m. After analysis for HbA1c (Alere Afinion; Abbott, Chicago, IL, USA) and fasting glucose, serum samples were stored at −20°C until analysis (analysis within 12 months). Samples were analyzed for calcium, phosphate, 25OH vitamin D, creatinine, urinary calcium, and urinary creatinine by standard method on an autoanalyzer (Cobas Integra 400plus; Roche Diagnostics, Basel, Switzerland). Procollagen type 1 N propeptide (P1NP), beta‐CrossLaps (CTX), intact parathyroid hormone (iPTH), and 25‐Hydroxyvitamin D (25OHD) were assessed in serum by electrochemiluminescence immunoassays (ECLIA) (Cobas® e411 autoanalyzer; Roche Diagnostics, Rotkreuz, Switzerland). The intraassay and interassay variation was 2.0% to 8.4% for CTX, 1.2% to 3.3% for P1NP, 2.2% to 10.7% for 25OHD, and 1.2% to 2.0% for iPTH, respectively. Serum bone‐specific alkaline phosphatase (BAP) was measured by ELISA (MicroVueBAP; Quidel, San Diego, CA, USA) with an intraassay variation of <5.8% and an interassay variation of 7.6%.

Sewing L., Potasso L., Baumann S., Schenk D., Gazozcu F., Lippuner K., Kraenzlin M., Zysset P, & Meier C. (2022). Bone Microarchitecture and Strength in Long‐Standing Type 1 Diabetes. Journal of Bone and Mineral Research, 37(5), 837-847.

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Vitamin D Levels in Transplant Patients

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Serum cholecalciferol (VD₃), 25OH vitamin D (25OHVD), and intact parathyroid hormone (iPTH) levels (pmol/L) were measured on pretransplant assessment workup appointment, one year, and two years after the transplant had done by using electrochemiluminescence immunoassay, Cobas e411 autoanalyzer (Roche Ltd., Basel, Switzerland). Despite previous reports, the definition of VD-D was suggested in this study to be below 25 nmol/L of the 25OHVD level [20 (link),21 (link),22 (link)]. Moreover, levels of Alkaline phosphatase (ALP) (U/L), calcium (mmol/L), phosphorus (mmol/L), magnesium (mmol/L), creatinine (umol/L), urea (mmol/L), potassium (mmol/L), and chloride (mmol/L) were measured by Roche/Hitachi modular Cobas c 701/702 tests.

Abulmeaty M.M., Almutawa D.A., Selimovic N., Almuammar M., Al-Khureif A.A., Hashem M.I., Hassan H.M, & Moety D.A. (2021). Impact of Vitamin D Supplementation on Bone Mineral Density and All-Cause Mortality in Heart Transplant Patients. Biomedicines, 9(10), 1450.

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Adjusting Immune Marker-Metabolite Correlations for CMV

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Previous studies reported that cytomegalovirus (CMV) seropositive and seronegative individuals differ in levels of CD4 and CD8 T-cell subsets, possibly due to repeated reactivation of CMV infection expanding memory and effector/memory T-cell subsets (25 (link), 26 (link)). To adjust for this potential difference in our analysis of the correlation of immune biomarkers with Trp metabolites, we assessed infection with CMV by measuring antibody status using fasting sodium heparin plasma analyzed with the CMV IgG Reagent Pack with analysis run on the Roche Diagnostics (Indianapolis, IN) Cobas e411 autoanalyzer according to the manufacturer’s instructions. Results are categorized as positive (“reactive”), borderline, and negative (“not-reactive”). One sample in this study was borderline and was considered negative during statistical analysis.

Riazati N., Kable M.E., Newman J.W., Adkins Y., Freytag T., Jiang X, & Stephensen C.B. (2022). Associations of microbial and indoleamine-2,3-dioxygenase-derived tryptophan metabolites with immune activation in healthy adults. Frontiers in Immunology, 13, 917966.

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Evaluating Metabolic Markers in Fasting Patients

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Blood samples were withdrawn under aseptic conditions at 9:00 a.m. on an empty stomach to measure complete blood count (CBC) using Sysmex XT-1800i Automated Hematology Analyzer, serum ferritin, HbA1c and fructosamine and fasting plasma glucose (FPG) by using cobas c 311 auto analyzer, Roche diagnostics, Germany, and fasting insulin level (FINS) by using electrochemiluminescence immunoassay using cobas e 411 auto analyzer, Roche diagnostics, Germany. To measure 2-h post-prandial blood glucose, each patient received oral glucose at a dosage of 1.75 g/kg, up to a maximum of 75 g dissolved in 200 ml of water, and 2-h later, second blood glucose measurement was obtained.
In addition, the Homeostatic Model Assessment for insulin resistance (HOMA-IR) and for insulin sensitivity (HOMA-IS) was calculated. 6, 10 Insulin resistance index ðHOMA À IRÞ ¼ ffasting insulin level ðmU=LÞ fasting plasma glucose ðmmol=LÞg=22:5 Insulin sensitivity index ðHOMA À ISÞ ¼ 1= È fasting insulin level ðmU=LÞ fasting plasma glucose ðmmol=LÞ

Mahmoud A.A., El-Hawy M.A., Allam E.T., Salem A.H, & Abo Hola A.S. (2024). HbA1c or fructosamine on evaluating glucose intolerance in children with beta- thalassemia. Pediatric research.

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Biomarker Analysis in Fasting Whole Blood

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A sample of whole blood (10 ml) was collected from the peripheral vein after 12.0 h fasting and then divided and transferred into three tubes: (i) 1.5 ml was transferred to a citrated tube for complete blood count, (ii) 1 ml was transferred to an ethylenediaminetetraacetic acid tube for RNA extraction, and (iii) the rest of the sample was transferred to a tube without anticoagulant for other laboratory tests. The blood in the third tube was immediately centrifuged for 20 min at the speed of 3000 rpm and after serum separation was stored at −80°C until the measurements. Serum levels of SDF-1 and CXCR4 were measured by commercially enzyme-linked immunosorbent assay (ELISA) kits (EASTBIOPHARM, Hangzhou Eastbiopharm Co. Ltd., China). High-sensitivity C-reactive protein (hs-CRP) and parathyroid hormone (PTH) levels (normal PTH range: 11.1–79.5 pg/ml) were measured using particle-enhanced immunoturbidimetric assay and electrochemiluminescent immunoassay method on Cobas e411 auto analyzer (Roche Diagnostics International Ltd, Basel, Switzerland), respectively. Other biochemical and hematologic parameters were measured using routine and standard laboratory methods.

Mousavi S.H., Dormanesh B., Shahidi S., Johari Moghadam A., Kazemi M, & Abediny A. (2019). Stromal Cell-derived Factor-1 and CXC Chemokine Receptor Type-4 are Associated with Cardiovascular Disease in Patients under Hemodialysis. International Journal of Preventive Medicine, 10, 219.

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