Helical CT images were all obtained with a 64-detector row CT scanner (LightSpeed VCT, GE Healthcare, Waukesha, WI). The CT image parameters were as follows: detector collimation, 1.25 or 0.625 mm; field of view, 36 cm; beam pitch, 1.375 to 1.500; beam width, 10 to 20 mm; gantry speed, 0.5 or 0.6 seconds per rotation; 120 kVp; 125 mA; reconstruction interval, 1 to 2.5 mm; and matrix, 512 Â 512 mm. The helical acquisitions were reformatted into contiguous 2.5-to 3.5-mm axial sections overlapping by 1 to 1.5 mm on a standard workstation. CT scanning was obtained 90 seconds after the administration of contrast material (100 mL of iopamidol [Iomeron 300 (Bracco, Milan, Italy)]) at a rate of 1.5 mL/s using a power injector. This was followed by a 20-cm 3 saline flush at a rate of 1.5 mL/s.
Iomeron 300
Manufactured by Bracco
Sourced in Italy, Germany
Iomeron 300 is an iodine-based contrast agent used for radiological imaging procedures. It is a sterile, aqueous solution containing 300 mg of iodine per milliliter. The core function of Iomeron 300 is to enhance the visibility of internal structures during medical imaging techniques such as computed tomography (CT) scans.
Automatically generated - may contain errors
Lab products found in correlation
Lightspeed vct, by GE Healthcare (3 mentions)
Mct plus, by Bayer (2 mentions)
Lightspeed vct xt, by GE Healthcare (2 mentions)
Iomeprol, by Bracco (2 mentions)
Fastview, by Terumo (1 mentions)
Somatom sensation 64, by Siemens (1 mentions)
Discovery ls, by GE Healthcare (1 mentions)
Light speed plus ct scanner, by GE Healthcare (1 mentions)
Advance nxi pet scanner, by GE Healthcare (1 mentions)
Biograph truepoint 64, by Siemens (1 mentions)
Somatom definition flash, by Siemens (1 mentions)
Somatom emotion 6, by Siemens (1 mentions)
Somatom sensation cardiac 64, by Siemens (1 mentions)
Xtravision, by Philips (1 mentions)
Somatom force, by Siemens (1 mentions)
Brilliance 40, by Philips (1 mentions)
Ge lightspeed vct 64, by GE Healthcare (1 mentions)
Aquilion 64, by Canon (1 mentions)
Lightspeed 16, by GE Healthcare (1 mentions)
17 protocols using iomeron 300
1
Contrast-Enhanced Helical CT Imaging Protocol
2
Canine CT Imaging with Iodine Contrast
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All of the CT examinations were performed on a 16-multislice unit (LightSpeed, GE HealthCare, Milwaukee, Wisconsin, USA) with the helical acquisition, automatic mA, 100 or 120 kV, rotation time 0.5—0.7 s, slice thickness 1.25—3.75 mm, pitch 0.938 or 1.375, reconstructed in a soft-tissue algorithm. The DFOV was customised to the size of the patient, and the matrix was 512 × 512. All images were displayed in a soft-tissue window (WW 350, WL 50). All of the dogs received iodine non-ionic contrast medium iomeprol in a dose of 600 mg I/kg (Iomeron 300, Bracco Imaging Deutschland GmbH, Konstanz, Germany). Contrast medium was administered into the cephalic vein with a power injector (MCT Plus, Medrad, Indianola, IA, USA) at a rate of 3 ml/s. All of the postcontrast series used in the study were acquired 90 to 120 s after the contrast medium administration. All of the settings in postcontrast series were the same as for the precontrast examinations. Dogs were scanned in sternal recumbency.
3
Intravascular Optical Frequency Domain Imaging of Carotid Artery Stents
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Following the CAS procedures, OCT imaging was performed using the Terumo Intravascular Optical frequency domain imaging (OFDI) system (LUNAWAVE, Terumo Corp., Tokyo, Japan). For this procedure, an imaging catheter (FastView, Terumo Corp., Tokyo, Japan) was inserted into the carotid artery beyond the distal end of the stent. Scanning was performed from the distal to the proximal portion of the stent using a built-in automatic pullback system while the common and external carotid arteries were occluded by using the balloons.
To remove blood from the vessel, during scanning, half-diluted contrast medium (Iomeron 300, Bracco, Milano, Italy) was infused continuously into the carotid arteries from the guiding catheter at a rate of 6 mL/s by a motor-driven injector. An in-stent tissue protrusion was defined as the presence of an intraluminal mass. The presence of in-stent tissue protrusion between the first and last frames in each cross section and the area of maximum projection was measured on the workstation of Terumo Intravascular OFDI system. All images were recorded digitally and analysed by two observers [M.T. and T.I.] who made a consensus evaluation.
To remove blood from the vessel, during scanning, half-diluted contrast medium (Iomeron 300, Bracco, Milano, Italy) was infused continuously into the carotid arteries from the guiding catheter at a rate of 6 mL/s by a motor-driven injector. An in-stent tissue protrusion was defined as the presence of an intraluminal mass. The presence of in-stent tissue protrusion between the first and last frames in each cross section and the area of maximum projection was measured on the workstation of Terumo Intravascular OFDI system. All images were recorded digitally and analysed by two observers [M.T. and T.I.] who made a consensus evaluation.
4
Conventional DSA Protocol for Angiography
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Conventional DSA runs were acquired in two orthogonal incidences (stationary anteroposterior and lateral planes) at registered magnification and field of view after manual injection of 1–2 mL of iodine contrast material (Iomeron 300, Bracco). Superselective angiograms were stored in XtravisionWorkstation and sent to the picture archiving and communication system (PACS) and a Macintosh workstation (Apple Inc, Cupertino, California, USA) with OsiriX installed (OsiriX Foundation, Geneva, Switzerland).
5
Iodine Contrast Media Effects on Urine
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The effect of iodine containing radiographic contrast media was assessed by serial dilutions (0%-50%) of the contrast agent Iomeprol (300 g/L; 500 mOsm/kg) (Iomeron 300; Bracco Imaging, Konstanz, Germany) [15] in pooled urine samples with a baseline osmolality of 1279 mOsm/kg. Consecutively, electrical conductivity, relative density and osmolality (measured and estimated) were measured in the mixed specimen. The theoretical osmolality of the mixture was based on the molecular mass of iomeprol (777 g/mol).
6
Post-Ablation CT Imaging Protocol
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Control CT scans were acquired 1 week after the ablation procedure on a 64-multidetector CT system (Somatom Sensation 64; Siemens Medical, Erlangen, Germany). The tube voltage was 120 kVp and the quality reference tube current was 120 mAs. Scans were acquired prior to administration of intravenous contrast agent (110 mL of Iomeron 300; Bracco Imaging), and in the arterial and portal venous phases, and reconstructed with slice thicknesses of 2–5 mm, 0.75–3 mm and 2 mm using a medium smooth B30f kernel.
7
CT and PET/CT Imaging for Lymph Node Evaluation
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CT scans were obtained with a 64-detector row scanner (Light Speed VCT XT; GE Healthcare, Milwaukee, WI, USA), using the enhanced helical technique (40 mA, 120 kVp, beam width of 10 20 mm, beam pitch of 1.375 1.5). For an enhancement study, 100 mL of contrast medium (Iomeron 300; Bracco, Milan, Italy) were administered intravenously. Lymph nodes with a short-axis diameter of more than 10 mm were considered positive for malignancy. If lymph nodes contained nodular or laminated calcification, they were regarded as benign, regardless of size (20 (link)).
Image acquisition of integrated PET/CT was performed using a PET/CT device (Discovery LS, GE Healthcare, Milwaukee, WI, USA) that consisted of an Advance NXi PET scanner and an eight-slice Light Speed Plus CT scanner. After fasting for at least 6 h before the PET/CT examination, patients received an intravenous injection of 370 MBq of 18F FDG and then rested for 45 min before imaging. Lymph nodes were considered positive for malignancy if the maximum standardized uptake value (SUVmax) was more than 2.5 on 18F FDG PET/CT (21 (link)).
Image acquisition of integrated PET/CT was performed using a PET/CT device (Discovery LS, GE Healthcare, Milwaukee, WI, USA) that consisted of an Advance NXi PET scanner and an eight-slice Light Speed Plus CT scanner. After fasting for at least 6 h before the PET/CT examination, patients received an intravenous injection of 370 MBq of 18F FDG and then rested for 45 min before imaging. Lymph nodes were considered positive for malignancy if the maximum standardized uptake value (SUVmax) was more than 2.5 on 18F FDG PET/CT (21 (link)).
8
Contrast-Enhanced PET/CT Imaging Protocol
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The [ 18 F]FDG PET/CT was performed on a 64-row hybrid PET/CT (Biograph TruePoint 64; Siemens Healthineers) and 32 participants (88.89%) of the PET/CT cohort received a contrast agent injection (1.5 ml/kg body weight iomepro; Iomeron ® 300, Bracco Austria). Due to a known allergy to the contrast media or poor renal function, four persons of the PET/CT cohort underwent a PET/CT without contrast. There were 39.47% of CT scans performed in the arterial and venous phases (either CT angiography of the thoracic aorta or the abdominal aorta). Only a venous phase was acquired in 50%, and 10.53% of the examination were performed as a low-dose scan without contrast.
9
Helical CT Imaging Protocol for Tumor Assessment
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All helical CT images were obtained with a 64 detector-row (LightSpeed VCT; GE Healthcare, Waukesha, WI, USA) CT scanner using the following parameters: detector collimation, 1.25 or 0.625 mm; field of view, 36 cm; 125 mA; 120 kVp; beam width, 10–20 mm; beam pitch, 1.375–1.5; section thickness 2.5 mm; and matrix, 512 × 512 mm. All patients underwent chest CT at full inspiration through breath hold to minimize the effect of the tumor motion due to breathing. Chest CT scanning was obtained 90 seconds after the administration of contrast material. A total of 1.5 mL/kg (body weight) Iomeron 300 (Iomeprol, 300 mg iodine/mL; Bracco; Milan, Italy) was injected at an infusion rate of 3 mL/s using a power injector (MCT Plus; Medrad; Pittsburgh, PA, USA). Image data were reconstructed with a soft-tissue algorithm for mediastinal window ranges and a bone algorithm for lung window images. Both mediastinal (width, 300 Hounsfield units [HU]; level, 20 HU) and lung (width, 1500 HU; level −700 HU) window images were displayed for tumor assessment. Chest CT images were obtained every two cycles (8 weeks) during the course of treatment.
10
Contrast-Enhanced CT Imaging Protocol
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All patients underwent contrast-enhanced CT with an iodine contrast injection of high concentration (300 mg I/mL, Iomeron 300, Bracco, Italy), a 90–130 mL volume (based on patient weight), and a 3–4 mL/s flow rate. The contrast-enhanced scan was triggered by 150 HU density in the abdominal aorta (at the level of the celiac axis) and the portal venous phase was acquired with a 60 s delay (standard protocol). Both the single portal venous phase and the venous phase of a multi-phase CT were included. The CT scans were acquired using three different CT scanners (Siemens SOMATOM Emotion 6, Siemens SOMATOM Sensation Cardiac 64 and Siemens SOMATOM Definition Flash—Siemens Healthcare, Berlin, Germany) with different acquisition parameters: tube voltage between 100 and 130 kVp, variable values between 0.61 and 0.98 mm for pixel spacing and between 1.5 mm and 2.5 mm for slice thickness; five different values for the reconstruction kernel (B31s, B40s, B20f, B30f, Br32f). The DICOM header of images was analyzed to retrieve the acquisition and reconstruction parameters for a subsequent reproducibility analysis of radiomic features.
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