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Transgenic heterozygous cre driver mice

Manufactured by Jackson ImmunoResearch
Sourced in United Kingdom

Transgenic heterozygous Cre-driver mice are genetically engineered mice that express the Cre recombinase enzyme in a specific cell or tissue type. The Cre recombinase can be used to conditionally activate or inactivate target genes in the mouse model.

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3 protocols using transgenic heterozygous cre driver mice

1

Mouse Husbandry and Experimental Procedures

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The data used here were obtained from the previous study by Lopes-dos-Santos et al. (2018) (20 (link)). Animals were male adult (4–7 months old) C57BL/6J mice (Charles River, UK) or transgenic heterozygous Cre-driver mice (Jackson Laboratories; obtained from C57BL/6J crossed with CamKIIa-Cre B6.Cg-Tg(Camk2a-cre)T29-1Stl/J, stock number 005359, RRID: IMSR_JAX:005359). All animals had free access to water and food in a dedicated housing facility with a 12-h light/12-h dark cycle (lights on at 7:00), 19–23 °C ambient temperature and 40–70% humidity. All mice were held in individually ventilated cages with wooden chew sticks and nestlets. The experimental procedures performed on these mice were conducted in accordance with the Animals (Scientific Procedures) Act, 1986 (United Kingdom), with final ethical review by the Animals in Science Regulation Unit of the UK Home Office.
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2

Neurobehavioral Protocols in Mice and Rats

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Animals used were male adult (4–7 months old) C57BL/6J mice (Charles River, UK) or transgenic heterozygous Cre-driver mice (Jackson Laboratories; obtained from C57BL/6J crossed with CamKIIa-Cre B6.Cg-Tg(Camk2a-cre)T29-1Stl/J, stock number 005359, RRID: IMSR_JAX:005359; or Dat-Cre B6.SJL-Slc6a3tm1.1(cre)Bkmn/J, stock number 006660, RRID: IMSR_JAX:006660). In addition, we used adult male Long-Evans rats (Harlan, UK) to test rat dorsal hippocampal CA1 LFPs for the presence of the theta-nested spectral components we identified in mice. All animals had free access to water and food in a dedicated housing facility with a 12/12 h light/dark cycle. They shared a cage with their littermates until the surgery. All experiments involving animals were conducted according to the UK Animals (Scientific Procedures) Act 1986 under personal and project licenses issued by the Home Office following ethical review.
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3

Mouse Husbandry and Experimental Procedures

Check if the same lab product or an alternative is used in the 5 most similar protocols
The data used here were obtained from the previous study by Lopes-dos-Santos et al. (2018) (20 (link)). Animals were male adult (4–7 months old) C57BL/6J mice (Charles River, UK) or transgenic heterozygous Cre-driver mice (Jackson Laboratories; obtained from C57BL/6J crossed with CamKIIa-Cre B6.Cg-Tg(Camk2a-cre)T29-1Stl/J, stock number 005359, RRID: IMSR_JAX:005359). All animals had free access to water and food in a dedicated housing facility with a 12-h light/12-h dark cycle (lights on at 7:00), 19–23 °C ambient temperature and 40–70% humidity. All mice were held in individually ventilated cages with wooden chew sticks and nestlets. The experimental procedures performed on these mice were conducted in accordance with the Animals (Scientific Procedures) Act, 1986 (United Kingdom), with final ethical review by the Animals in Science Regulation Unit of the UK Home Office.
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