ACh, PE, and glibenclamide were obtained from Sigma (St. Louis, MO, USA), whereas cromakalim was obtained from Tocris Cookson (Bristol, UK). All drugs were dissolved in Krebs solution except for cromakalim, which was dissolved in 10% DMSO and Krebs solution. The same concentration of DMSO alone had no effect on vessel diameter.
Cromakalim
Manufactured by Bio-Techne
Sourced in United States
Cromakalim is a potassium channel opener that is commonly used in research applications. It is a synthetic compound that acts on ATP-sensitive potassium channels, which are involved in various physiological processes. Cromakalim is often utilized in in vitro and in vivo studies to investigate the role of potassium channels in various biological systems.
Automatically generated - may contain errors
Lab products found in correlation
Glibenclamide, by Merck Group (2 mentions)
Doxazosin, by Merck Group (1 mentions)
Loperamide hydrochloride, by Merck Group (1 mentions)
Tyrode s solution, by Merck Group (1 mentions)
Carbachol, by Merck Group (1 mentions)
Isoprenaline, by Merck Group (1 mentions)
Krebs solution, by Merck Group (1 mentions)
Potassium chloride (kcl), by Merck Group (1 mentions)
Acetylcholine, by Merck Group (1 mentions)
Phenylephrine, by Merck Group (1 mentions)
2 protocols using cromakalim
1
Vascular Tone Modulation Experiments
2
Pharmacological Assessment of Vasodilator Mechanisms
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All the chemicals were 99.9% pure and of research-grade quality. Acetylcholine, carbachol, doxazosin, glibenclamide, isoprenaline, loperamide hydrochloride, phenylephrine, and potassium chloride were obtained from Sigma Chemical Co. (St Louis, MO, USA), while cromakalim was procured from Tocris, Ellisville, MN, USA. Castor oil was purchased from Karachi Chemicals (Karachi, Pakistan). The chemicals used to make the physiological solutions, i.e., Krebs solution and Tyrode’s solution, were procured from Merck (Dermstadt, Germany) and BDH (Poole, England).
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