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Hdaci

Manufactured by Selleck Chemicals
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HDACi is a type of laboratory equipment used for the analysis and study of histone deacetylase (HDAC) enzymes. HDAC enzymes play a crucial role in the regulation of gene expression by modifying the acetylation state of histones, which are proteins that package and organize DNA within the cell nucleus. HDACi is designed to inhibit the activity of HDAC enzymes, enabling researchers to investigate the functional consequences of HDAC inhibition in various biological systems.

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Lab products found in correlation

Belinostat pxd101, by Selleck Chemicals (1 mentions) Dmso solvent, by Merck Group (1 mentions) Mg132, by Merck Group (1 mentions) Paclitaxel, by Merck Group (1 mentions) Panobinostat lbh589, by Selleck Chemicals (1 mentions) Trametinib gsk1120212, by Selleck Chemicals (1 mentions) Adavosertib mk 1775, by Selleck Chemicals (1 mentions) Wee1i, by Selleck Chemicals (1 mentions) Sotorasib amg 510, by MedChemExpress (1 mentions) Bix02189, by Bio-Techne (1 mentions) Afatinib, by LC Laboratories (1 mentions) Midostaurin pkc412, by LC Laboratories (1 mentions)

3 protocols using hdaci

1

Histone Deacetylase Inhibitor Evaluation

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The HDACi, belinostat (PXD101) and vorinostat (SAHA / MK-0683) and romidepsin (depsipeptide / FK-228) were purchased from Selleck (Houston, TX). Paclitaxel, MG132 and DMSO solvent were purchased from Sigma-Aldrich (St. Louis, MO).
Marlow L.A., Bok I., Smallridge R.C, & Copland J.A. (2015). RhoB upregulation leads to either apoptosis or cytostasis through differential target selection. Endocrine-related cancer, 22(5), 777-792.
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2

Pharmacological Inhibition of Oncogenic Signaling

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Pharmacological inhibitors to MEK1/2 (Trametinib/GSK1120212, MEKi), HDAC (Panobinostat/LBH589, HDACi) and WEE1 (Adavosertib/MK-1775, WEE1i) were acquired from Selleckchem; to MEK5-K2 (BIX02189, MEK5i) was purchased from Tocris. Lestaurtinib/L6307 (mtPKCi), Neratinib (pan-HERi) and Afatinib (EGFRi) were obtained from LC Laboratories, and Midostaurin/PKC412 (mtPKCi), Sotorasib/AMG-510 (KRASi), Darovasertib (PKCAi), Barasertib (AURKBi), Adagrasib/MRTX849 (KRASi) and MG132 (proteasome inhibitor) were purchased from MedChemExpress. Dabrafenib (RAFi) was a kind gift from Imanol Arozarena (Navarrabiomed, Spain).
Macaya I., Roman M., Welch C., Entrialgo-Cadierno R., Salmon M., Santos A., Feliu I., Kovalski J., Lopez I., Rodriguez-Remirez M., Palomino-Echeverria S., Lonfgren S.M., Ferrero M., Calabuig S., Ludwig I.A., Lara-Astiaso D., Jantus-Lewintre E., Guruceaga E., Narayanan S., Ponz-Sarvise M., Pineda-Lucena A., Lecanda F., Ruggero D., Khatri P., Santamaria E., Fernandez-Irigoyen J., Ferrer I., Paz-Ares L., Drosten M., Barbacid M., Gil-Bazo I, & Vicent S. (2023). Signature-driven repurposing of Midostaurin for combination with MEK1/2 and KRASG12C inhibitors in lung cancer. Nature Communications, 14, 6332.
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3

HDAC Inhibitor Synthesis and Preparation

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HDACi were purchased from SelleckChem, Houston, USA. An HDAC1,2 specific HDACi was synthesized similar to compound 5a in ref.57 (link). The HDAC6-specific HDACi was synthesized similar to compound 7 in ref.58 (link). All HDACi were dissolved in DMSO to a final concentration of 5 mM. For in vivo studies Vorinostat was dissolved in DMSO/PBS 50 mg/mL.
Kroesen M., Büll C., Gielen P.R., Brok I.C., Armandari I., Wassink M., Looman M.W., Boon L., den Brok M.H., Hoogerbrugge P.M, & Adema G.J. (2016). Anti-GD2 mAb and Vorinostat synergize in the treatment of neuroblastoma. Oncoimmunology, 5(6), e1164919.
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