Meldrum's acid, 1,1-bis(methylthio)-2-nitro ethylene, diamines, various isatin derivatives, p-toluenesulfonic acid and solvents were purchased from Sigma-Aldrich and used as received without further purification. Melting points (mp) were determined with an electrothermal 9100 apparatus. Infrared (IR) spectra were recorded on a Bruker Tensor 27 spectrometer. Nuclear magnetic resonance (NMR) spectra were obtained on a Bruker DRX-300 Avance instrument (300 MHz for 1H and 75.4 MHz for 13C) with CDCl3 and DMSO as solvents. Chemical shifts were expressed in parts per million (ppm) relative to internal TMS, and the coupling constant (J) was reported in hertz (Hz). All of the compounds were analyzed for mass data using Agilent 5975C VL MSD with a Triple-Axis Detector operating at an ionization potential of 70 eV.
Agilent 5975c vl msd
Manufactured by Agilent Technologies
Sourced in United States
The Agilent 5975C VL MSD is a gas chromatography-mass spectrometry (GC-MS) system. It is designed to provide high-performance analysis of compounds in complex samples. The system includes an electron ionization (EI) ion source and a triple-axis quadrupole mass analyzer.
Automatically generated - may contain errors
Lab products found in correlation
Drx 300 avance instrument, by Bruker (3 mentions)
Tensor 27 spectrometer, by Bruker (3 mentions)
Meldrum s acid, by Merck Group (1 mentions)
2004 series 2 chn elemental analyzer, by PerkinElmer (1 mentions)
Dimedone, by Merck Group (1 mentions)
Vario el analyzer, by Elementar (1 mentions)
Aluminum tlc plates, by Merck Group (1 mentions)
Spectrum 100 ftir spectrophotometer, by PerkinElmer (1 mentions)
Avance 3, by Bruker (1 mentions)
4 protocols using agilent 5975c vl msd
1
Synthesis and Characterization of Nitro Ethylene Derivatives
2
Characterization of Chemical Compounds
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All commercially available reagents and other solvents were purchased from Aldrich and Merck chemical Co. and used without further purification. The NMR spectra were recorded with a Bruker DRX-300 AVANCE instrument (300 MHz for 1H and 75.4 MHz for 13C) with DMSO-d6 as solvent. Chemical shifts are given in ppm (δ), and coupling constant (J) are reported in Hertz (Hz). Melting points were measured with an electrothermal 9100 apparatus. Mass spectra were recorded with an Agilent 5975C VL MSD with Triple-Axis detector operating at an ionization potential of 70 eV. IR spectra were measured with Bruker Tensor 27 spectrometer. Elemental analyses for C, H and N were performed using a PerkinElmer 2004 series [II] CHN elemental analyzer.
3
Synthesis and Characterization of Substituted Pyrimidine Derivatives
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The dimedone, phenylglyoxal monohydrate, various anilines and other chemicals and solvents were obtained from Merck and Aldrich and were used without further purification. NMR spectra were recorded with a Bruker DRX-300 Avance instrument (300 MHz for 1H and 75.4 MHz for 13C) with DMSO and CDCl3 as solvent. Chemical shifts are given in ppm (δ), and coupling constant (J) are reported in hertz (Hz). Melting points were measured with an electrothermal 9100 apparatus. Mass spectra were recorded with an Agilent 5975C VL MSD with Triple-Axis Detector operating at an ionization potential of 70 eV. IR spectra were measured with, Bruker Tensor 27 spectrometer.
4
Characterization of Novel Compounds
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The chemicals used were of reagent grade. Removal of all solvents was carried out under reduced pressure. The 1H and 13C NMR spectra were recorded in d6-DMSO 2% solutions on a “Bruker Avance III” (400.13 and 100.61 MHz) (Karlsruhe, Germany). Chemical shifts δ are given in ppm referring to the signal center using the solvent peaks for reference: d6-DMSO 2.50 ppm. IR spectra were recorded on a Spectrum 100 FT-IR spectrophotometer (PerkinElmer) using the universal ATR sampling accessory Agilent 5975C VL MSD (Waltham, MA, USA) with triple axis detector, performed using the method by Druta: temperature 60–320 °C, run time: 32.333 min, flow 1.1062 mL/min, pressure 9.418 psi and method steroid 250, temperature 180–250 °C, run time 29 min, flow 1.1062 mL/ min, pressure 16.528 psi. All products were analyzed by CHN elemental analysis (Elementar Vario EL analyzer) (Santa Clara, CA, USA). Melting points (uncorrected) were determined on a Boetius apparatus (Dresden, Germany). Thin-layer chromatography was carried out on Merck aluminum TLC plates, silica gel 60 coated with fluorescent indicator F254.
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