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Mumt mice 002288

Manufactured by Jackson ImmunoResearch

MuMT−/− mice (002288) are genetically engineered mice that lack the expression of the mu heavy chain (μ) of the B cell receptor. This mutation results in the absence of mature B cells, which are an essential component of the adaptive immune system. These mice provide a model to study the role of B cells in various immunological processes.

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2 protocols using mumt mice 002288

1

Genetic Modulation of Th17 Immunity

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Rag2−/− mice (008449), Tcrδ−/− mice (002120), muMT−/− mice (002288), Tcrα−/− mice (002116), Il17a−/− mice (016879) were from Jackson Lab. Il17f−/− mice were from Dr. Sarah L. Gaffen and Dr.Yoichiro Iwakura’s lab, Il17rc−/− and Il17ra−/− were from Amgen, Il17RCflox/flox mice were from Dr. Jay K. Kolls’ lab31 . Vγ6Vδ1 Tg mice were from Dr. Diane Mathis’ lab. Adiponectin Cre mice (028020) and UCP1 Cre mice (024670) were from Jackson lab32 . VGLUT3-ires-Cre mice were from Dr. Bradford Lowell’s lab33 . TGFβ antibody (Bioxcell # BE0057 Clone 1D11.16.8) and Isotype control antibody (Bioxcell # BE0083) were i.p. injected to WT B6 mice for 3 weeks at 10mg/kg 3 times a week. sb431542 was i.p. injected to WT B6 mice at 4.2mg/kg/day for 3 weeks. All animal studies were approved by the Institutional Animal Care and Use Committee of Beth Israel Deaconess Medical Center.
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2

Genetic Modulation of Th17 Immunity

Check if the same lab product or an alternative is used in the 5 most similar protocols
Rag2−/− mice (008449), Tcrδ−/− mice (002120), muMT−/− mice (002288), Tcrα−/− mice (002116), Il17a−/− mice (016879) were from Jackson Lab. Il17f−/− mice were from Dr. Sarah L. Gaffen and Dr.Yoichiro Iwakura’s lab, Il17rc−/− and Il17ra−/− were from Amgen, Il17RCflox/flox mice were from Dr. Jay K. Kolls’ lab31 . Vγ6Vδ1 Tg mice were from Dr. Diane Mathis’ lab. Adiponectin Cre mice (028020) and UCP1 Cre mice (024670) were from Jackson lab32 . VGLUT3-ires-Cre mice were from Dr. Bradford Lowell’s lab33 . TGFβ antibody (Bioxcell # BE0057 Clone 1D11.16.8) and Isotype control antibody (Bioxcell # BE0083) were i.p. injected to WT B6 mice for 3 weeks at 10mg/kg 3 times a week. sb431542 was i.p. injected to WT B6 mice at 4.2mg/kg/day for 3 weeks. All animal studies were approved by the Institutional Animal Care and Use Committee of Beth Israel Deaconess Medical Center.
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