Recombinant human IFN-β (beta) (300-02BC) and human IFN-λ (lambda) (300-02 L) were obtained from PeproTech and were used to test IFN sensitivity of full-length, authentic SARS-CoV-2 variants (IFN was added 18 h prior to inoculation and removed prior to virus addition). Recombinant human IFN-β (beta) 1a (11415-1) and human IFN-λ (lambda) (11725-1) were obtained from PBL Assay Science and were used to test IFN sensitivity of VSV-based pseudoviruses (IFN was added 18 h prior to inoculation and removed prior to virus addition). The following inhibitors were reconstituted in DMSO: E64d (Sigma; E8640), camostat mesylate (Sigma; SML0057), incyclinide (MedChemExpress; HY-13648), apratastat (MedChemExpress; HY-119307), batimastat (SelleckChem: S7155), EG00229 (SelleckChem; E1119). Bafilomycin A1 (Sigma; SML1661) was received as a ready-made solution in DMSO, and amphotericin B (Sigma; A2942) was received as a ready-made solution in deionized water.
Human ifn λ lambda 11725 1
Manufactured by PBL Assay Science
Human IFN-λ (lambda) (11725-1) is a recombinant protein that represents the lambda subtype of human interferon-lambda. It is a cytokine that plays a role in innate immune responses. The core function of this product is to enable research on the biological activities and signaling pathways of human interferon-lambda.
Automatically generated - may contain errors
Lab products found in correlation
Bafilomycin a1, by Merck Group (2 mentions)
Camostat mesylate, by Merck Group (2 mentions)
Batimastat, by Selleck Chemicals (2 mentions)
Apratastat, by MedChemExpress (2 mentions)
Amphotericin b, by Merck Group (2 mentions)
Incyclinide, by MedChemExpress (2 mentions)
Recombinant human ifn β beta 300 02bc, by Thermo Fisher Scientific (2 mentions)
Recombinant human ifn β beta 1a 11415 1, by PBL Assay Science (2 mentions)
Eg00229, by Selleck Chemicals (2 mentions)
Human ifn λ lambda, by Thermo Fisher Scientific (1 mentions)
2 protocols using human ifn λ lambda 11725 1
1
SARS-CoV-2 Variant Interferon Sensitivity
2
Antiviral Interferon and Inhibitor Screening
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Recombinant human IFN-β (beta) (300-02BC) and human IFN-λ (lambda) (300-02L) were obtained from PeproTech and were used to test IFN sensitivity of full-length, authentic SARS-CoV-2 variants (IFN was added 18 hours prior to inoculation and removed prior to virus addition). Recombinant human IFN-β (beta) 1a (11415-1) and human IFN-λ (lambda) (11725-1) were obtained from PBL Assay Science and were used to test IFN sensitivity of VSV-based pseudoviruses (IFN was added 18 hours prior to inoculation and removed prior to virus addition). The following inhibitors were reconstituted in DMSO: E64d (Sigma; E8640), camostat mesylate (Sigma; SML0057), incyclinide (MedChemExpress; HY-13648), apratastat (MedChemExpress; HY-119307), batimastat (SelleckChem: S7155), EG00229 (SelleckChem; E1119). Bafilomycin A1 (Sigma; SML1661) was received as a ready-made solution in DMSO and amphotericin B (Sigma; A2942) was received as a ready-made solution in deionized water.
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