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Triacetin

Manufactured by Thermo Fisher Scientific
Sourced in United States, Germany

Triacetin is a chemical compound commonly used as a plasticizer in the production of various materials. It is a clear, colorless liquid with a slightly sweet odor. Triacetin is often used in the manufacturing of certain types of lab equipment and supplies, where its properties as a plasticizer may be beneficial. However, a detailed and unbiased description of its core function without extrapolation on intended use cannot be provided within the constraints of this request.

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5 protocols using triacetin

1

Formulation Development of Ketorolac Tromethamine

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Ketorolac tromethamine (KT) was obtained from TCI chemicals (Tokyo, Japan). Fertilized white horn eggs were purchased from Heath Farm (Fakenham, UK). Transcutol P, Labrafac PG, Labrafac lipophile WL 1349, Labrafil M 1944 CS, Labrafil M 2125 CS, Labrafil M 2130 CS, and Labrasol ALF were received as a gift from Gattefosse SAS (Leon, France). Tween 20, Tween 60, Tween 80, Span 20, triacetin, ethyl oleate, dimethyl isosorbide, ethylene glycol, propylene glycol and isopropyl myristate were obtained from ACROS organics (Fair Lawn, NJ, USA). Cremophor RH 40, Cremophor EL, butylene glycol, pentylene glycol, hexylene glycol, Span 80, 2-butyl-2-ethyl-1,3-propanediol, (2,3-butanediol), NaOH were purchased From Sigma-Aldrich (Taufkirchen, Germany). Sodium chloride, sodium bicarbonate, and calcium chloride dehydrate were from Fisher Scientific UK Ltd. (Loughborough, UK). Other chemicals used were of analytical grade.
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2

Borneol-Based Hydrogel for Doxycycline Delivery

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The procurement of borneol was carried out at the Chareorsuk-osop herbal shop located in Nakhon Pathom, Thailand. The experiment involved the preparation of sodium hydroxide (lot no. AF310204, Ajax Finechem, NSW, Australia) and potassium dihydrogen orthophosphate (lot no. E23W60, Ajax Finechem, NSW, Australia) in phosphate buffered solution (PBS) having a pH of 6.8. Agarose (Lot No. H7014714, Vivantis, Selangor Darul Ehsan, Malaysia) was used to determine the gel formation behavior. The model drug utilized in this study was doxycycline hyclate (lot no. 20071121, Huashu Pharmaceutical Corporation, Shijiazhuang, China). The regulating agent utilized in the study was triacetin, sourced from Acros Organics in Nidderau, Germany and identified by lot number A0375797. The substance referred to as NMP (lot no. 144560-118, QReC, Auckland, New Zealand) was utilized as a solvent.
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3

Lipid-based Finasteride Formulation

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Finasteride was a kind gift from Ferozsons Laboratories limited, Pakistan. Labrafil M 1944 CS and M 2125 CS as long chain triglycerides (LCT), Capryol 90, Capryol PGMC and Labrafac lipophile WL 1349 as medium chain triglycerides (MCT) (Gattefosse, France). Soyabean oil, olive oil and coconut oil were purchased from local market. Triacetin as short chain triglyceride (SCT) (Alfa Aesar, Germany), Cremophore (RH 40), Tween-80 (Sigma Aldrich, Germany), PEG 400 (Bio-Labs, Islamabad). All the chemical and solvents used were of analytical grade.
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4

Polyoxymethylene Copolymer Solution-Dissolution Process

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Injection-grade polyoxymethylene copolymer (Hostaform C52021, Celanese Co., Dallas, TX, USA) granules, with a degree of crystallinity of 55%, as determined via density (see Section 2.3.7), were used as the feed material for the solution-dissolution process. The solvents used for screening were acetophenone (99%, Alfa Aesar, Ward Hill, MA, USA), triacetin (99%, Alfa Aesar, Ward Hill, MA, USA), benzaldehyde (≥99.5%, Carl Roth, Karlsruhe, Germany), benzyl benzoate (99%, Alfa Aesar, Ward Hill, MA, USA), benzyl ether (98%, Sigma-Aldrich, St. Louis, MO, USA), and diethylene glycol n-butyl ether acetate (DEGBEA) (≥97%, Carl Roth, Karlsruhe, Germany). Technical ethanol (96%, VWR, Radnor, PA, USA) was used as the washing solvent. All solvents were used without further purification.
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5

Formulation of Lipid-Based Drug Delivery Systems

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RES (purity > 98%), Span 80, Tween 80, and Tween 20 were obtained from Tokyo Chemical Industry (Tokyo, Japan). Capryol 90 (propylene glycol monocaprylate) was purchased from Gattefosse (Saint-Priest Cedex, France). Tricaprylin (glycerol trioctanoate), Cremophor EL (polyoxyl 35 hydrogenated castor oil) and α-tocopherol were supplied by Sigma-Aldrich (St. Louis, MO, USA). Triacetin (glyceryl triacetate) was obtained from Alfa Aesar (Ward Hill, MA, USA). Span 65 was purchased from Merck (Darmstadt, Germany). Acetonitrile for HPLC were obtained from Tedia (Fairfield, OH, USA).
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