Genetic Mouse Model for Endothelial Tracing

Eng^flox/flox:Cdh5(PAC)CreER^T2:R26Ryfp were generated by inter-crosses of the following mice:
Eng^flox/flox58 (link), Cdh5(PAC)-CreER^T259 (link), and R26Ryfp (also denoted Ai3 in short or alternatively B6.Cg-Gt(ROSA)26Sor^{tm3(CAG-EYFP)Hze}/J (Stock Number 007903, The Jackson Laboratory). Animal housing and procedures were in accordance with Swedish legislation and approved by the local animal ethics committees.

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Sugden W.W., Meissner R., Aegerter-Wilmsen T., Tsaryk R., Leonard E.V., Bussmann J., Hamm M.J., Herzog W., Jin Y., Jakobsson L., Denz C, & Siekmann A.F. (2017). Endoglin controls blood vessel diameter through endothelial cell shape changes in response to haemodynamic cues. Nature cell biology, 19(6), 653-665.

Publication 2017

B6.Cg-Gt(ROSA)26Sortm3(CAG-EYFP)Hze/J

Animal ethics committees Cdh5 Mice Rosa

Corresponding Organization :

Other organizations : Max Planck Institute for Molecular Biomedicine, University of Zurich, Karolinska Institutet

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Variable analysis

independent variables

Eng^flox/flox
Cdh5(PAC)-CreER^T2
R26Ryfp

dependent variables

Not explicitly mentioned

control variables

Animal housing and procedures were in accordance with Swedish legislation and approved by the local animal ethics committees

controls

No specific positive or negative controls were mentioned in the input text.

Annotations

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